{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T18:41:58Z","timestamp":1762540918955,"version":"build-2065373602"},"reference-count":30,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T00:00:00Z","timestamp":1762473600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To assess the excess cardiovascular disease (CVD) mortality risk in patients with gastric cancer (GC) compared with the general population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using data from the National Cancer Institute\u2019s Surveillance, Epidemiology, and End Results (SEER) program, we conducted a retrospective, population-based cohort study of 41,083 GC patients \u226530 years old between January 1, 1990, and December 31, 2021. A reference cohort from the corresponding general population was also included. Incidence rate ratios (IRRs) for CVD mortality were estimated using Poisson regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>GC patients were associated with a higher risk of CVD mortality relative to the general population (IRR: 1.46; 95% CI: 1.40\u20131.52). The relative risk was highest among younger patients aged 30\u201339 years (IRR: 7.69; 95% CI: 2.48\u201323.86). Cardiovascular mortality risk peaked during the first month after cancer diagnosis (IRR: 11.52; 95% CI: 9.97\u201313.31). The relationship between GC and CVD mortality varied according to demographic and clinical characteristics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These population-based findings support early cardiac assessment and comprehensive risk stratification in GC care. Prospective studies with richer confounder data are needed to test whether these strategies improve outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0335989","type":"journal-article","created":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T18:35:28Z","timestamp":1762540528000},"page":"e0335989","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Risk of cardiovascular mortality in patients with gastric 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