{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T19:19:05Z","timestamp":1767295145134,"version":"3.45.0"},"reference-count":67,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"PhD Scholarship Program of the Vingroup Innovation Foundation (VINIF), Vingroup Big Data Institute","award":["VINIF.2020.TS.68"],"award-info":[{"award-number":["VINIF.2020.TS.68"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:p>\n                    This study reports for the first time the occurrence of\n                    <jats:italic>\n                      <jats:italic>\n                        <jats:italic>Ganoderma ellipsoideum<\/jats:italic>\n                      <\/jats:italic>\n                    <\/jats:italic>\n                    , a wood-decaying fungus, in Vietnam. Species identification was achieved through morphological characterization and sequencing of the internal transcribed spacer region of nuclear ribosomal DNA. Phylogenetic analysis confirmed that the Vietnamese specimens clustered within the\n                    <jats:italic>\n                      <jats:italic>\n                        <jats:italic>Ganoderma ellipsoideum<\/jats:italic>\n                      <\/jats:italic>\n                    <\/jats:italic>\n                    taxon, supported by high bootstrap and posterior probability values (90%\/1.00). Morphological features further indicated its placement within the\n                    <jats:italic>\n                      <jats:italic>Ganoderma applanatum\u2013australe<\/jats:italic>\n                    <\/jats:italic>\n                    complex.\n                    <jats:italic>\n                      <jats:italic>In vitro<\/jats:italic>\n                    <\/jats:italic>\n                    cytotoxicity assays revealed that the ethanol extract and its sub-fractions (n-hexane, ethyl acetate, aqueous) exerted inhibitory effects on human breast cancer MCF-7 cells, with the ethyl acetate fraction showing the strongest activity.\n                    <jats:italic>\n                      <jats:italic>In silico<\/jats:italic>\n                    <\/jats:italic>\n                    molecular docking demonstrated strong binding affinities between major triterpenoid compounds and key breast cancer-related proteins, including HPA, MELK, CK2\u03b1, and NUDT5. These findings not only establish\n                    <jats:italic>\n                      <jats:italic>Ganoderma ellipsoideum<\/jats:italic>\n                    <\/jats:italic>\n                    as a newly recorded species in Vietnam, but also suggest its promising potential as a source of anticancer agents.\n                  <\/jats:p>","DOI":"10.1371\/journal.pone.0336024","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T18:26:41Z","timestamp":1763144801000},"page":"e0336024","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Taxonomic characterization and cytotoxic potential of Vietnamese Ganoderma ellipsoideum against human breast cancer MCF-7 cells"],"prefix":"10.1371","volume":"20","author":[{"given":"Trang Thi Thu","family":"Nguyen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4359-4924","authenticated-orcid":true,"given":"Phu Tran Vinh","family":"Pham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viet An Thi","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trinh Thi Tuyet","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linh Thuoc","family":"Tran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phu Chi Hieu","family":"Truong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3061-7952","authenticated-orcid":true,"given":"Manh Hung","family":"Tran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2025,11,14]]},"reference":[{"key":"pone.0336024.ref001","first-page":"1","article-title":"Medicinal Mushrooms: Past, Present and Future.","author":"S Chang","year":"2023"},{"issue":"1","key":"pone.0336024.ref002","doi-asserted-by":"crossref","DOI":"10.1186\/s43094-021-00202-w","article-title":"Medicinal plants and their components for wound healing applications","volume":"7","author":"A Sharma","year":"2021","journal-title":"Futur J Pharm Sci"},{"issue":"11","key":"pone.0336024.ref003","doi-asserted-by":"crossref","first-page":"3566","DOI":"10.3390\/molecules27113566","article-title":"Phytochemistry and Biological Activity of Medicinal Plants in Wound Healing: An Overview of Current Research","volume":"27","author":"S Vitale","year":"2022","journal-title":"Molecules"},{"issue":"3","key":"pone.0336024.ref004","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"F Bray","year":"2024","journal-title":"CA Cancer J Clin"},{"key":"pone.0336024.ref005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/B978-0-323-90951-8.00010-2","article-title":"1 - Introduction to cancer and treatment approaches.","volume-title":"Paclitaxel","author":"MS Chandraprasad","year":"2022"},{"issue":"4","key":"pone.0336024.ref006","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1016\/j.gendis.2022.02.007","article-title":"Cancer chemotherapy and beyond: Current status, drug candidates, associated risks and progress in targeted therapeutics","volume":"10","author":"U Anand","year":"2022","journal-title":"Genes Dis"},{"key":"pone.0336024.ref007","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/bs.acr.2022.03.007","article-title":"An overview of chemotoxicity and radiation toxicity in cancer therapy","volume":"155","author":"V Yazbeck","year":"2022","journal-title":"Adv Cancer Res"},{"issue":"2","key":"pone.0336024.ref008","first-page":"69","article-title":"Global cancer statistics","volume":"61","author":"A Jemal","year":"2011","journal-title":"CA Cancer J Clin"},{"key":"pone.0336024.ref009","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.breast.2022.08.010","article-title":"Current and future burden of breast cancer: Global statistics for 2020 and 2040","volume":"66","author":"M Arnold","year":"2022","journal-title":"Breast"},{"issue":"5","key":"pone.0336024.ref010","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1097\/CEJ.0000000000000204","article-title":"Ganoderma: insights into anticancer effects","volume":"25","author":"NV Kladar","year":"2016","journal-title":"Eur J Cancer Prev"},{"key":"pone.0336024.ref011","volume-title":"Magical Mushroom: Ganoderma\u2014A Promising Treatment for Cancer. 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