{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T09:09:22Z","timestamp":1772701762546,"version":"3.50.1"},"reference-count":23,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T00:00:00Z","timestamp":1762992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"This study was supported by a research grant from Daewoong Pharmaceutical. The funder had no role in the design of the study, its conduct and analysis, or the interpretation of the study results"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"\n Objective<\/jats:title>\n The management of foot disorders often involves anti-inflammatory drugs for chronic inflammation and pain. Combining anti-inflammatory drugs with vitamin B complex may have a synergistic effect, but its efficacy in foot disorders remains unclear. This study aimed to investigate the effects of combining vitamin B complex with anti-inflammatory drugs in patients with foot disorders.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n This study enrolled 201 patients aged\u2009\u2265\u200919 years with foot disorders of Achilles tendinitis, foot or ankle arthritis, Civinini-Morton syndrome (Morton\u2019s neuroma), or plantar fasciitis from four hospitals in Korea between October 2020 and December 2021. The patients were randomized in a 1:1 ratio to receive either aceclofenac 100\u2009mg twice daily alone (control group, n\u2009=\u200977) or aceclofenac 100\u2009mg and vitamin B complex twice daily (experimental group, n\u2009=\u200979) for 4 weeks. Among 201 randomized participants, 156 patients(79 in the experimental group and 77 in the control group) completed all scheduled follow-up visits and were included in the final analysis. The primary outcome measure was pain as assessed using the 10-cm visual analog scale (VAS). The secondary outcome measures were health-related quality of life and foot\/ankle outcomes as assessed using the EuroQol 5 Dimension (EQ-5D) questionnaire and the Foot and Ankle Outcome Score (FAOS), respectively.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n VAS scores were more significantly reduced in the experimental group than in the control group, after 4 weeks (\u22122.87\u2009\u00b1\u20091.86 (from 6.95\u2009\u00b1\u20090.15 to 4.08\u2009\u00b1\u20090.17) vs. \u22120.91\u2009\u00b1\u20091.81 (from 5.99\u2009\u00b1\u20090.14 to 5.08\u2009\u00b1\u20090.21], p\u2009<\u20090.001). Similarly, improvements in the EQ-5D scores were significantly greater in the experimental group (0.079\u2009\u00b1\u20090.143 (from 0.69\u2009\u00b1\u20090.01 to 0.77\u2009\u00b1\u20090.01] vs 0.008\u2009\u00b1\u20090.111 (from 0.75\u2009\u00b1\u20090.01 to 0.76\u2009\u00b1\u20090.01], p\u2009=\u20090.001). Additionally, the increase in FAOS after treatment was significantly larger in the experimental group (9.94\u2009\u00b1\u200914.38 vs 2.97\u2009\u00b1\u200911.79, p\u2009=\u20090.001). Subgroup analysis revealed the combined therapy was particularly more effective in patients with chronic symptoms lasting over 3 months and in conditions like plantar fasciitis, foot or ankle arthritis, and Civinini-Morton syndrome.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Combining vitamin B complex with anti-inflammatory drugs effectively reduces pain and improves function in patients with chronic foot disorders. This combination therapy offers a promising strategy for improving pain control and functional outcomes in orthopaedic outpatient settings.<\/jats:p>\n <\/jats:sec>\n \n Trial registration<\/jats:title>\n \n This study was registered at Clinical Research Information Service, Korea Centers for Disease Control and Prevention, Ministry of Health and WELFARE (Republic of Korea,\n https:\/\/cris.nih.go.kr\/cris\/search\/detailSearchEn.do?seq=27976<\/jats:ext-link>\n ), a WHO International Clinical Trials Registry Platform primary register setup, on May 19,2020 under the registration number KCT0005035.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1371\/journal.pone.0336373","type":"journal-article","created":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T18:41:32Z","timestamp":1763059292000},"page":"e0336373","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Vitamin B supplementation enhances the efficacy of non-steroidal anti-inflammatory drugs in patients with painful foot and ankle conditions: A multicenter, prospective, randomized controlled trial"],"prefix":"10.1371","volume":"20","author":[{"given":"Myung-Geun","family":"Song","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chul Hyun","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young-Rak","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7384-8382","authenticated-orcid":true,"given":"Gi-Won","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9601-396X","authenticated-orcid":true,"given":"Bom Soo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2025,11,13]]},"reference":[{"key":"pone.0336373.ref001","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.maturitas.2016.06.011","article-title":"Chronic foot pain in older people","volume":"91","author":"HB Menz","year":"2016","journal-title":"Maturitas"},{"issue":"12","key":"pone.0336373.ref002","first-page":"1287","article-title":"A systematic review of systematic reviews on the epidemiology, evaluation, and treatment of plantar fasciitis","volume":"11","author":"HC Rhim","year":"2021","journal-title":"Life (Basel)"},{"issue":"4","key":"pone.0336373.ref003","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1177\/1938640013493464","article-title":"The diagnosis and management of Morton\u2019s neuroma: a literature review","volume":"6","author":"S Jain","year":"2013","journal-title":"Foot Ankle 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