{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T02:13:22Z","timestamp":1779329602686,"version":"3.51.4"},"reference-count":40,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Evidence on long-term outcomes of endoscopic retrograde cholangiopancreatography (ERCP) for pancreatic duct stones (PDS) in children with chronic pancreatitis (CP) remains scarce. This study aimed to evaluate the long-term clinical outcomes of ERCP in this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A single-center retrospective cohort study was conducted on children with CP and PDS who underwent ERCP at our Hospital (2008.1.1\u20132024.12.31). Follow-up assessed stone clearance, complications, pain relief, pain type, growth, quality of life (QoL), and long-term complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 90 children with CP and PDS were enrolled in this single-center retrospective cohort study. ERCP achieved 72.1% complete stone clearance; overall complications were 9.6%. Among the 90 patients, 77 (85.6%) completed the full follow-up. Post-ERCP, all abdominal pain subtypes significantly decreased (P\u2009&lt;\u20090.001), with 70.1% complete pain relief. Height and weight increased (P\u2009&lt;\u20090.01); QoL (PedsQL\u21224.0) scores rose from 69 to 85 points (P\u2009&lt;\u20090.001). Long-term complications included new diabetes (5.2%) and steatorrhea (5.2%); PDS recurrence was 7.8%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>ERCP is safe and effective for children with CP and PDS, significantly improving long-term pain, growth, and QoL, supporting its role as a first-line therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0336638","type":"journal-article","created":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T18:24:48Z","timestamp":1772216688000},"page":"e0336638","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Long-term clinical outcomes of endoscopic retrograde cholangiopancreatography for pancreatic duct stone treatment in children with chronic 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