{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T03:43:01Z","timestamp":1773373381115,"version":"3.50.1"},"reference-count":54,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      Mobility disability is associated with functional decline in older adults. Resistance training (RT) improves mobility disability, but adherence to national RT guidelines is poor. We evaluated the effects of a 12-week brief, home-based functional RT program, FAST (\n                      <jats:italic>Functional Activity Strength Training)<\/jats:italic>\n                      -2, on adherence and functional impairment in older, inactive adults\u2009\u2265\u200965 years of age, with pre-existing walking difficulty.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Eligible older adults were randomized using stratified assignment based on biological sex and age (65\u221272 and 73+) to either the FAST-2 intervention involving a 4-minute daily workout of four exercises lasting 30 seconds each or the delayed treatment control condition. Video coaching at baseline and at weeks 2, 4 and 8, provided feedback on exercise form, modifications and progression. Daily email reminders were sent for workout completion, and to report exercise performance and rate perceived exertion. Performance and adherence feedback were emailed biweekly. Functional performance was measured by video using the Five-Times Sit-to-Stand (FTSTS) test, One-Legged Stance Test (OLST) and the 30-second chair stand test at baseline and at weeks 6 and 12.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Ninety-seven participants were randomized to either the FAST-2 treatment intervention (n\u2009=\u200944) or the delayed treatment control condition (n\u2009=\u200953). The linear mixed-effect model showed the intervention group decreased the FTSTS by 2.3 seconds (95% CI: 0.5\u20134.1, p\u2009=\u20090.01), increased OLST by 3.6 seconds (95% CI: 0.6\u20136.5, p\u2009=\u20090.02) and increased the number of chair stands by 4.2 repetitions (95% CI: 2.8\u20135.7, p\u2009&lt;\u20090.001) more than the control group over 12 weeks. Intervention participants completed the workout 81% of the days. No significant adverse events were reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The 12-week FAST-2 intervention, including only 60-seconds of lower extremity exercises in older individuals with pre-existing walking difficulty, yielded improvement in functional performance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec005\">\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>\n                      ClinicalTrials.gov: ID\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT05697497\" xlink:type=\"simple\">NCT05697497<\/jats:ext-link>\n                    <\/jats:p>\n                    <jats:p>Study Details | NCT05697497 | Functional Activity Strength Training | ClinicalTrials.gov<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0336748","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T17:32:04Z","timestamp":1773336724000},"page":"e0336748","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Brief daily functional strength training to improve functional performance in older adults with mobility disability: A randomized trial"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9410-1248","authenticated-orcid":true,"given":"Smita","family":"Dandekar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6739-0726","authenticated-orcid":true,"given":"Jordan","family":"Kurth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3770-4143","authenticated-orcid":true,"given":"Yimeng","family":"Shang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan G.","family":"Stine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew A.","family":"Ladwig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David E.","family":"Conroy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn H.","family":"Schmitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liza S.","family":"Rovniak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Silvis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret","family":"Danilovich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noel","family":"Ballentine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Pierwola-Gawin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shouhao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Sciamanna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2026,3,12]]},"reference":[{"key":"pone.0336748.ref001","unstructured":"Vespa J, Medina L, Armstrong DM. Demographic turning points for the United States: Population Projections for 202 Vespa J, Medina L, Armstrong DM. Demographic Turning Points for theUnited States: Population Projections for 2020 to 2060. U.S. Census Bureau;2020. Accessed June 13, 2023. https:\/\/www.census.gov\/library\/publications\/2020\/demo\/p25-1144.html"},{"issue":"16","key":"pone.0336748.ref002","first-page":"1","article-title":"Health characteristics of adults aged 55 years and over: United States, 2004-2007","volume":"2009","author":"CA Schoenborn","year":"2009","journal-title":"Natl Health Stat Report"},{"issue":"32","key":"pone.0336748.ref003","doi-asserted-by":"crossref","first-page":"882","DOI":"10.15585\/mmwr.mm6732a3","article-title":"Prevalence of disabilities and health care access by disability status and type among adults - United States, 2016","volume":"67","author":"CA Okoro","year":"2018","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"6","key":"pone.0336748.ref004","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1093\/geront\/gnu014","article-title":"Older Adults\u2019 perceptions of mobility: A metasynthesis of qualitative studies","volume":"55","author":"RT Goins","year":"2015","journal-title":"Gerontologist"},{"issue":"10","key":"pone.0336748.ref005","article-title":"Hospital stays and probable dementia as predictors of relocation to long-term care facilities","volume":"30","author":"R Amini","year":"2024","journal-title":"Am J Manag Care"},{"issue":"2","key":"pone.0336748.ref006","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1007\/s11606-010-1543-2","article-title":"Ability to walk 1\/4 mile predicts subsequent disability, mortality, and health care costs","volume":"26","author":"SE Hardy","year":"2011","journal-title":"J Gen Intern Med"},{"issue":"2","key":"pone.0336748.ref007","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.gerinurse.2017.08.002","article-title":"The impact of mobility limitations on health outcomes among older adults","volume":"39","author":"S Musich","year":"2018","journal-title":"Geriatr Nurs"},{"issue":"2","key":"pone.0336748.ref008","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.jjcc.2015.09.005","article-title":"Effects of resistance training on muscle strength, exercise capacity, and mobility in middle-aged and elderly patients with coronary artery disease: A meta-analysis","volume":"68","author":"S Yamamoto","year":"2016","journal-title":"J Cardiol"},{"issue":"12","key":"pone.0336748.ref009","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1007\/s40279-015-0385-9","article-title":"Dose-response relationships of resistance training in healthy old adults: A systematic review and meta-analysis","volume":"45","author":"R Borde","year":"2015","journal-title":"Sports Med"},{"issue":"3","key":"pone.0336748.ref010","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.jsams.2013.05.009","article-title":"Influence of strength training variables on strength gains in adults over 55 years-old: A meta-analysis of dose-response relationships","volume":"17","author":"NL Silva","year":"2014","journal-title":"J Sci Med Sport"},{"key":"pone.0336748.ref011","article-title":"Trends in meeting the physical activity guidelines: Muscle-strengthening alone and combined with aerobic activity, United States, 1998-2018","volume":"18","author":"ET Hyde","year":"2021","journal-title":"J Phys Act Health"},{"issue":"4","key":"pone.0336748.ref012","first-page":"454","article-title":"Physical activity in U.S.: Adults compliance with the Physical Activity Guidelines for Americans","volume":"40","author":"JM Tucker","year":"2011","journal-title":"Am J Prev Med"},{"key":"pone.0336748.ref013","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.ypmed.2016.05.009","article-title":"Prevalence and trends in physical activity among older adults in the United States: A comparison across three national surveys","volume":"89","author":"SK Keadle","year":"2016","journal-title":"Prev Med"},{"key":"pone.0336748.ref014","doi-asserted-by":"crossref","DOI":"10.5888\/pcd12.140574","article-title":"Participation in older adult physical activity programs and risk for falls requiring medical care, Washington State, 2005-2011","volume":"12","author":"MA Greenwood-Hickman","year":"2015","journal-title":"Prev Chronic Dis"},{"issue":"1","key":"pone.0336748.ref015","doi-asserted-by":"crossref","first-page":"43","DOI":"10.2337\/dc06-1013","article-title":"Impact of a managed-Medicare physical activity benefit on health care utilization and costs in older adults with diabetes","volume":"30","author":"HQ Nguyen","year":"2007","journal-title":"Diabetes Care"},{"issue":"1","key":"pone.0336748.ref016","article-title":"Managed-Medicare health club benefit and reduced health care costs among older adults","volume":"5","author":"HQ Nguyen","year":"2008","journal-title":"Prev Chronic Dis"},{"issue":"10","key":"pone.0336748.ref017","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1007\/s40279-021-01490-1","article-title":"No Time to Lift? Designing Time-Efficient Training Programs for Strength and Hypertrophy: A Narrative Review","volume":"51","author":"VM Iversen","year":"2021","journal-title":"Sports Med"},{"key":"pone.0336748.ref018","doi-asserted-by":"crossref","unstructured":"Kurth JD, Sciamanna CN, Danilovich MK. Older US adults prefer short, frequent resistance training programs, especially those with walking difficulty. Paper presented at: Gerontological Society of America; November 10, 2023. 2023.","DOI":"10.1093\/geroni\/igad104.3506"},{"issue":"5","key":"pone.0336748.ref019","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0302892","article-title":"Comparing preferences to evaluations of barrier self-efficacy for two strength training programs in US older adults","volume":"19","author":"JD Kurth","year":"2024","journal-title":"PLoS One"},{"issue":"4","key":"pone.0336748.ref020","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0154075","article-title":"Twelve weeks of sprint interval training improves indices of cardiometabolic health similar to traditional endurance training despite a five-fold lower exercise volume and time commitment","volume":"11","author":"JB Gillen","year":"2016","journal-title":"PLoS One"},{"issue":"7","key":"pone.0336748.ref021","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1007\/s40279-014-0180-z","article-title":"Effects of low-volume high-intensity interval training (HIT) on fitness in adults: A meta-analysis of controlled and non-controlled trials","volume":"44","author":"M Weston","year":"2014","journal-title":"Sports Med"},{"issue":"5","key":"pone.0336748.ref022","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1007\/s40279-018-0872-x","article-title":"Effect of resistance training frequency on gains in muscular strength: A systematic review and meta-analysis","volume":"48","author":"J Grgic","year":"2018","journal-title":"Sports Med"},{"issue":"12","key":"pone.0336748.ref023","doi-asserted-by":"crossref","first-page":"2585","DOI":"10.1007\/s40279-017-0762-7","article-title":"The effect of weekly set volume on strength gain: A meta-analysis","volume":"47","author":"GW Ralston","year":"2017","journal-title":"Sports Med"},{"issue":"8","key":"pone.0336748.ref024","doi-asserted-by":"crossref","DOI":"10.1016\/S2468-2667(25)00164-1","article-title":"Daily steps and health outcomes in adults: A systematic review and dose-response meta-analysis","volume":"10","author":"D Ding","year":"2025","journal-title":"Lancet Public Health"},{"issue":"1","key":"pone.0336748.ref025","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1080\/17437199.2015.1104258","article-title":"The effectiveness of multi-component goal setting interventions for changing physical activity behaviour: A systematic review and meta-analysis","volume":"10","author":"D McEwan","year":"2016","journal-title":"Health Psychol Rev"},{"key":"pone.0336748.ref026","doi-asserted-by":"crossref","first-page":"101307","DOI":"10.1016\/j.pmedr.2020.101307","article-title":"Feasibility and impact of a 1-minute daily functional exercise regimen prescribed to older adults by their primary care physician","volume":"21","author":"CN Sciamanna","year":"2021","journal-title":"Prev Med Rep"},{"key":"pone.0336748.ref027","doi-asserted-by":"crossref","first-page":"105318","DOI":"10.1016\/j.archger.2023.105318","article-title":"A meta-analysis on the impact of resistance training on phase angle in middle-aged and older individuals","volume":"119","author":"S Liu","year":"2024","journal-title":"Arch Gerontol Geriatr"},{"issue":"4","key":"pone.0336748.ref028","first-page":"338","article-title":"Revision of the Physical Activity Readiness Questionnaire (PAR-Q)","volume":"17","author":"S Thomas","year":"1992","journal-title":"Can J Sport Sci"},{"issue":"9","key":"pone.0336748.ref029","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1097\/00005650-200209000-00007","article-title":"Six-item screener to identify cognitive impairment among potential subjects for clinical research","volume":"40","author":"CM Callahan","year":"2002","journal-title":"Med Care"},{"issue":"6","key":"pone.0336748.ref030","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1249\/00005768-198315060-00015","article-title":"A category-ratio perceived exertion scale: Relationship to blood and muscle lactates and heart rate","volume":"15","author":"BJ Noble","year":"1983","journal-title":"Med Sci Sports Exerc"},{"issue":"11","key":"pone.0336748.ref031","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1249\/MSS.0000000000000664","article-title":"Updating ACSM\u2019s recommendations for exercise preparticipation health screening","volume":"47","author":"D Riebe","year":"2015","journal-title":"Med Sci Sports Exerc"},{"issue":"2","key":"pone.0336748.ref032","doi-asserted-by":"crossref","DOI":"10.1093\/geronj\/49.2.M85","article-title":"A short physical performance battery assessing lower extremity function: Association with self-reported disability and prediction of mortality and nursing home admission","volume":"49","author":"JM Guralnik","year":"1994","journal-title":"J Gerontol"},{"issue":"4","key":"pone.0336748.ref033","doi-asserted-by":"crossref","DOI":"10.1093\/gerona\/55.4.M221","article-title":"Lower extremity function and subsequent disability: Consistency across studies, predictive models, and value of gait speed alone compared with the short physical performance battery","volume":"55","author":"JM Guralnik","year":"2000","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"8","key":"pone.0336748.ref034","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1111\/j.1532-5415.2004.52366.x","article-title":"Psychometric comparisons of the timed up and go, one-leg stand, functional reach, and Tinetti balance measures in community-dwelling older people","volume":"52","author":"M-R Lin","year":"2004","journal-title":"J Am Geriatr Soc"},{"issue":"2","key":"pone.0336748.ref035","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1080\/02701367.1999.10608028","article-title":"A 30-s chair-stand test as a measure of lower body strength in community-residing older adults","volume":"70","author":"CJ Jones","year":"1999","journal-title":"Res Q Exerc Sport"},{"issue":"6","key":"pone.0336748.ref036","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2012-001777","article-title":"Psychometric properties of a questionnaire to assess exercise-related musculoskeletal injuries in older adults attending a community-based fitness facility","volume":"2","author":"L Stathokostas","year":"2012","journal-title":"BMJ Open"},{"key":"pone.0336748.ref037","unstructured":"Adult Activity: An Overview. Physical Activity Basics. https:\/\/www.cdc.gov\/physicalactivity\/basics\/adults\/index.htm. Accessed 2023 October 1."},{"issue":"7","key":"pone.0336748.ref038","first-page":"425","article-title":"Exercise prescriptions in older adults","volume":"95","author":"PG Lee","year":"2017","journal-title":"Am Fam Physician"},{"issue":"2","key":"pone.0336748.ref039","doi-asserted-by":"crossref","first-page":"61","DOI":"10.20982\/tqmp.04.2.p061","article-title":"Confidence intervals from normalized data: A correction to Cousineau (2005)","volume":"4","author":"RD Morey","year":"2008","journal-title":"TQMP"},{"issue":"10","key":"pone.0336748.ref040","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.4187\/respcare.06694","article-title":"Minimum clinically important difference in 30-s sit-to-stand test after pulmonary rehabilitation in subjects with COPD","volume":"64","author":"A Zanini","year":"2019","journal-title":"Respir Care"},{"key":"pone.0336748.ref041","doi-asserted-by":"crossref","first-page":"233","DOI":"10.3233\/VES-2006-164-510","article-title":"The five times sit to stand test: responsiveness to change and concurrent validity in adults undergoing vestibular rehabilitation","volume":"16","author":"BM Meretta","year":"2006","journal-title":"J Vestib Res"},{"key":"pone.0336748.ref042","unstructured":"Five Times Sit to Stand Test. Physiopedia. https:\/\/www.physiopedia.com\/Five_Times_Sit_to_Stand_Test. Accessed 2023 October 1."},{"issue":"26","key":"pone.0336748.ref043","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000034160","article-title":"Optimal procedure and characteristics in using five times sit to stand test among older adults: A systematic review","volume":"102","author":"AA Albalwi","year":"2023","journal-title":"Medicine (Baltimore)"},{"key":"pone.0336748.ref044","unstructured":"5tsts-pocket-guide-v2-proof9-(2)38db36a5390366a68a96ff00001fc240.pdf."},{"issue":"2","key":"pone.0336748.ref045","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1123\/japa.7.2.162","article-title":"Functional fitness normative scores for community-residing older adults, ages 60-94","volume":"7","author":"J Rikli RE a","year":"1999","journal-title":"Journal of Aging and Physical Activity"},{"key":"pone.0336748.ref046","unstructured":"46.30 second Chair Stand Test (30sCST)."},{"issue":"3","key":"pone.0336748.ref047","first-page":"100169","article-title":"Optimizing One-leg standing test duration for screening functional decline in community-dwelling older adults. archives of gerontology and geriatrics plus","volume":"2","author":"I Akira","year":"2025","journal-title":"Gerontol Geriatr Plus"},{"key":"pone.0336748.ref048","unstructured":"Single leg stance test. Physiopedia. https:\/\/www.physio-pedia.com\/Single_Leg_Stance_Test. Accessed 2023 October 1."},{"issue":"3","key":"pone.0336748.ref049","doi-asserted-by":"crossref","DOI":"10.2196\/mhealth.8518","article-title":"Patient involvement with home-based exercise programs: Can connected health interventions influence adherence?","volume":"6","author":"R Argent","year":"2018","journal-title":"JMIR Mhealth Uhealth"},{"issue":"2","key":"pone.0336748.ref050","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.physio.2015.10.003","article-title":"Interventions to aid patient adherence to physiotherapist prescribed self-management strategies: A systematic review","volume":"102","author":"K Peek","year":"2016","journal-title":"Physiotherapy"},{"key":"pone.0336748.ref051","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.exger.2018.12.016","article-title":"Repeated sit-to-stand exercise enhances muscle strength and reduces lower body muscular demands in physically frail elders","volume":"116","author":"E Fujita","year":"2019","journal-title":"Exp Gerontol"},{"issue":"9","key":"pone.0336748.ref052","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/S0895-4356(02)00410-9","article-title":"Comparison of the responsiveness of the Barthel Index and the motor component of the Functional Independence Measure in stroke: The impact of using different methods for measuring responsiveness","volume":"55","author":"D Wallace","year":"2002","journal-title":"J Clin Epidemiol"},{"issue":"2","key":"pone.0336748.ref053","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.jamda.2014.07.020","article-title":"Mobility of Vulnerable Elders study: effect of the sit-to-stand activity on mobility, function, and quality of life","volume":"16","author":"SE Slaughter","year":"2015","journal-title":"J Am Med Dir Assoc"},{"key":"pone.0336748.ref054","unstructured":"Perrin A, Atske S. 7% of Americans don\u2019t use the internet. Who are they?. Pew Research Center. 2021. 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