{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T19:14:19Z","timestamp":1789586059460,"version":"build-2803163510"},"reference-count":66,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Xinjiang Uygur Autonomous Region Health Commission","award":["TSYC202301B038"],"award-info":[{"award-number":["TSYC202301B038"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sepsis incidence is rising, but its pathogenesis remains unclear. This study aimed to identify therapeutic targets.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Three GEO datasets (GSE154918, GSE32707, GSE54514) were analyzed after batch correction. Differentially expressed genes (DEGs) were identified, and those related to pyroptosis\/migration were cross-analyzed. Functional enrichment (GO\/KEGG) and interaction networks (PPI, mRNA-miRNA, mRNA-TF, mRNA-drug) were constructed. External validation used GSE57065, excluding non-significant genes. ROC analysis and immune infiltration were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      3566 DEGs (1715 up, 1851 down) were identified, with 23 linked to pyroptosis\/migration. Enrichment analysis highlighted roles in cell adhesion, cytokine regulation, and pathways like IL-17, TNF, and Toll-like receptor signaling. mRNA-miRNA interactions for 12 key genes were predicted. After validation, eight key genes remained:\n                      <jats:italic>TLR2, SIRT1, PTGS2, MAPK14, IL18, ICAM1, CD274<\/jats:italic>\n                      , and\n                      <jats:italic>CASP3<\/jats:italic>\n                      . Immune infiltration revealed varied effects on MAPK14.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Key gene alterations may serve as sepsis biomarkers, and miRNA dysregulation could play a critical role in sepsis pathophysiology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0336982","type":"journal-article","created":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T18:28:31Z","timestamp":1763490511000},"page":"e0336982","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["PPI-based screening of hub genes related to sepsis migration\/pyroptosis and immune infiltration 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