{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:03:03Z","timestamp":1787022183127,"version":"build-2736575974"},"reference-count":44,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T00:00:00Z","timestamp":1765152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Key Clinical Specialty Scientific Research Project","award":["(Z2023047)"],"award-info":[{"award-number":["(Z2023047)"]}]},{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"crossref","award":["(2025JJ80547)"],"award-info":[{"award-number":["(2025JJ80547)"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The association between lactate dehydrogenase (LDH) and clinical outcomes in sepsis was explored based on MIMIC-IV database.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This was a retrospective study. Models including unadjusted model and adjusted models were performed for exploring the association of LDH with 30-day mortality and 1-year mortality. The smooth fitting curves were constructed by using generalized additive model. The predictive value of LDH for clinical outcomes in sepsis was evaluated. The statistical software of EmpowerStats (\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www\" xlink:type=\"simple\">http:\/\/www<\/jats:ext-link>\n                      . empowerstats. com) and R (\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.R-project.org\" xlink:type=\"simple\">http:\/\/www.R-project.org<\/jats:ext-link>\n                      ) were applied for analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>6775 sepsis patients were included. After adjusted for all potential confounders, for every 100 IU\/L increment in LDH, the risk of 30-day mortality and 1-year mortality increased by 11% (odds ratio (OR)=1.11, 95%CI:1.08\u20131.13, P\u2009&lt;\u20090.0001) and 12% (OR=1.12, 95%CI:1.09\u20131.14, P\u2009&lt;\u20090.0001), respectively. The areas under the ROC curve of LDH for predicting mortalities of 30-day and 1-year were 0.667 (95%CI:0.652\u20130.681) and 0.646 (95%CI: 0.632\u20130.660), respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>LDH was positively correlated with 30-day and 1-year mortalities in sepsis and the relationship was nonlinear.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0337213","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T18:24:05Z","timestamp":1765218245000},"page":"e0337213","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":4,"title":["Lactate dehydrogenase is an indicator for outcomes of short-term and long-term in septic 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