{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T18:39:27Z","timestamp":1776451167955,"version":"3.51.2"},"reference-count":41,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014570","name":"Khon Kean University","doi-asserted-by":"publisher","award":["Young Researcher Development Project of Khon Kaen University Year 2025"],"award-info":[{"award-number":["Young Researcher Development Project of Khon Kaen University Year 2025"]}],"id":[{"id":"10.13039\/501100014570","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Research fund, Faculty of Medicine, Khon Kaen University","award":["IN68034"],"award-info":[{"award-number":["IN68034"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:p>\n                    Coriander is a cultivated aromatic herb used as a culinary ingredient and in traditional medicinal treatments worldwide. Coriander essential oil contains various bioactive constituents with antibacterial, antioxidant, and anti-inflammatory effects. The oil also has antifungal activity against\n                    <jats:italic>Candida albicans,<\/jats:italic>\n                    the most common opportunistic fungal pathogen causing infections at various body sites. Furthermore, the oil can increase macrophage phagocytic activity. However, its effect on other macrophage functions during\n                    <jats:italic>C. albicans<\/jats:italic>\n                    infection is still unclear. This study aims to investigate the effect of coriander leaf essential oil on macrophage activity via the\n                    <jats:italic>NF-\u03baB<\/jats:italic>\n                    gene expression during\n                    <jats:italic>C. albicans<\/jats:italic>\n                    infection. RAW264.7, a murine macrophage cell line, was cultured with viable\n                    <jats:italic>C. albicans<\/jats:italic>\n                    , either in the absence or presence of the oil (0\u2009\u2212\u200950 \u03bcg\/mL). The fungal killing activity, pro- and anti-inflammatory cytokine production, and\n                    <jats:italic>NF-\u03baB<\/jats:italic>\n                    gene expression were assessed. Our results revealed the potential of coriander leaf essential oil as an immunomodulator that enhances macrophage responses to\n                    <jats:italic>C. albicans<\/jats:italic>\n                    via the activation of the\n                    <jats:italic>NF-\u03baB<\/jats:italic>\n                    gene. These findings may help to further the development of coriander leaf essential oil as an adjuvant antifungal and immunomodulatory medication.\n                  <\/jats:p>","DOI":"10.1371\/journal.pone.0337300","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T17:39:46Z","timestamp":1776447586000},"page":"e0337300","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Coriander leaf essential oil as an immunomodulator: Enhancing NF-\u03baB-driven RAW246.7 murine macrophages response to Candida albicans"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7212-2522","authenticated-orcid":true,"given":"Pratsanee","family":"Hiengrach","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pasinee","family":"Sangsiwarit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Waewta","family":"Kuwatjanakul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kittipan","family":"Samerpitak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pitchaya","family":"Luksanawilas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2026,4,17]]},"reference":[{"key":"pone.0337300.ref001","doi-asserted-by":"crossref","first-page":"102014","DOI":"10.1016\/j.bcab.2021.102014","article-title":"Trends in diabetes care with special emphasis to medicinal plants: Advancement and treatment","volume":"33","author":"B Tripathy","year":"2021","journal-title":"Biocatal Agric Biotechnol"},{"key":"pone.0337300.ref002","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.foodres.2017.11.019","article-title":"Coriander (Coriandrum sativum): A promising functional food toward the well-being","volume":"105","author":"V Prachayasittikul","year":"2018","journal-title":"Food Res Int"},{"issue":"1","key":"pone.0337300.ref003","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27010209","article-title":"Coriandrum sativum L.: A review on ethnopharmacology, phytochemistry, and cardiovascular benefits","volume":"27","author":"NN Mahleyuddin","year":"2021","journal-title":"Molecules"},{"issue":"3","key":"pone.0337300.ref004","doi-asserted-by":"crossref","first-page":"282","DOI":"10.3390\/foods9030282","article-title":"Antioxidant, Antimicrobial and Antibiofilm Activity of Coriander (Coriandrum sativum L.) 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