{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T18:40:27Z","timestamp":1764700827239,"version":"3.46.0"},"reference-count":63,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T00:00:00Z","timestamp":1764633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-21-CE13-0025"],"award-info":[{"award-number":["ANR-21-CE13-0025"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007522","name":"Mus\u00c3\u00a9um National d'Histoire Naturelle","doi-asserted-by":"publisher","award":["Axonto"],"award-info":[{"award-number":["Axonto"]}],"id":[{"id":"10.13039\/501100007522","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001823","name":"Ministerstvo \u00c5\u00a0kolstv\u00c3, Ml\u00c3\u00a1de\u00c5\u00bee a T\u00c4\u203alov\u00c3\u00bdchovy","doi-asserted-by":"publisher","award":["LM2023051"],"award-info":[{"award-number":["LM2023051"]}],"id":[{"id":"10.13039\/501100001823","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:p>\n                    Acoustic communication, a cornerstone of social interactions in mammals, relies on both vocal (effector) and auditory (receptor) organs, which display remarkable morphological diversity across species. The molecular mechanisms supporting the coordinated diversification of effector and receptor systems along with the evolution of species-specific acoustic communication are still poorly understood. A plausible hypothesis is that common genetic pathways orchestrate the parallel morphogenesis of vocal and auditory structures. Here, we addressed this question by generating mutant mice with targeted inactivation of\n                    <jats:italic>Dlx5\/6<\/jats:italic>\n                    genes in the\n                    <jats:italic>Sox10<\/jats:italic>\n                    lineage, which includes neural crest and otic placode derivatives that contribute to the formation of vocal tract and ear components. We show that\n                    <jats:italic>Dlx5\/6<\/jats:italic>\n                    inactivation led to simultaneous patterning defects in the outer, middle and inner ear and of the jaw, pharynx and larynx musculoskeletal systems. We further show that\n                    <jats:italic>Dlx5\/6<\/jats:italic>\n                    modulate the BMP signalling pathway in both pharyngeal arches and otic vesicle, revealing a common\n                    <jats:italic>Dlx5\/6-BMP<\/jats:italic>\n                    axis acting concurrently within the\n                    <jats:italic>Sox10<\/jats:italic>\n                    derivatives. These findings highlight a pleiotropic role of\n                    <jats:italic>Dlx5\/6<\/jats:italic>\n                    in vocal and auditory morphogenesis, thereby suggesting their contribution in the co-adaptation of effector and receptor organs and in the diversification of acoustic communication in mammals.\n                  <\/jats:p>","DOI":"10.1371\/journal.pone.0337426","type":"journal-article","created":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T18:28:47Z","timestamp":1764700127000},"page":"e0337426","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pleiotropic function of Dlx5\/6 in the development of mammalian vocal and auditory organs"],"prefix":"10.1371","volume":"20","author":[{"given":"Frida","family":"S\u00e1nchez-Garrido","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria","family":"Bouzerand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5200-7365","authenticated-orcid":true,"given":"Mark\u00e9ta","family":"Kaiser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7926-3261","authenticated-orcid":true,"given":"Chlo\u00e9","family":"Chaumeton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anastasia","family":"Fontaine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom\u00e1\u0161","family":"Zikmund","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jozef","family":"Kaiser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0563-9607","authenticated-orcid":true,"given":"\u00c9glantine","family":"Heude","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2025,12,2]]},"reference":[{"issue":"1","key":"pone.0337426.ref001","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/s41467-020-14356-3","article-title":"The 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