{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T09:44:29Z","timestamp":1774431869003,"version":"3.50.1"},"reference-count":54,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T00:00:00Z","timestamp":1765411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100020884","name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo","doi-asserted-by":"publisher","award":["1221680"],"award-info":[{"award-number":["1221680"]}],"id":[{"id":"10.13039\/501100020884","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018735","name":"Fondo de Financiamiento de Centros de Investigaci\u00f3n en \u00c1reas Prioritarias","doi-asserted-by":"crossref","award":["15130011"],"award-info":[{"award-number":["15130011"]}],"id":[{"id":"10.13039\/501100018735","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100018735","name":"Fondo de Financiamiento de Centros de Investigaci\u00f3n en \u00c1reas Prioritarias","doi-asserted-by":"crossref","award":["1523A0004"],"award-info":[{"award-number":["1523A0004"]}],"id":[{"id":"10.13039\/501100018735","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Kidney diseases pose considerable challenges to health systems affecting millions of people worldwide. In Latin America there are limited epidemiological studies on these conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to describe the national age-adjusted hospitalization trends for acute kidney injury (AKI) and chronic kidney disease (CKD) in the Chilean population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective study using a secondary data from hospitalized cases diagnosed with AKI and CKD in Chile, from 2010 to 2019. Age-adjusted hospitalization rates and JoinPoint regression analysis were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Between 2010 and 2019, 26,715 hospitalizations of patients diagnosed with AKI and 99,816 patients with CKD were recorded. Nationally, long-term trends in age-adjusted hospitalization rates for AKI increased by 9.1% annually (95% CI: 8.0 to 10.5), whereas CKD hospitalization rates declined by 4.35% (95% CI: \u22125.76 to \u22122.99) over the study period. Short-term trends in AKI hospitalization rates showed initial declines in Maule between 2010\u20132017 (\u22127.97%, 95% CI: \u221213.63 to \u22126.04) followed by increases from 2017 to 2019 (8.45%, 95% CI: \u22124.08 to 17.66), whereas Valpara\u00edso (7.2%, 95% CI: 5.2 to 9.5) experienced steady growth. Although CKD rates generally declined, central regions such as O\u2019Higgins and Maule showed increases between 2016\u20132019 (10.6%, 95% CI: 5.1 to 19.9) and 2017\u20132019 (8.5%, 95% CI: \u22124.1 to 17.7), respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec005\">\n                    <jats:title>Conclusion\/Interpretation<\/jats:title>\n                    <jats:p>This study highlights AKI as a growing public health challenge nationwide, with increasing hospitalization rates. At the same time, CKD hospitalizations show a reduction, although regional disparities remain a concern. Efforts should focus on enhanced integral surveillance to address these trends effectively across the country.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0337640","type":"journal-article","created":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T18:28:14Z","timestamp":1765477694000},"page":"e0337640","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Acute kidney injury and chronic kidney disease in Chile: Temporal trends in hospitalization rates from 2010 to 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