{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T19:32:34Z","timestamp":1765567954439,"version":"3.48.0"},"reference-count":69,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      STH and\n                      <jats:italic>S. mansoni<\/jats:italic>\n                      pose significant public health challenges in regions with inadequate sanitation. Existing research on\n                      <jats:italic>S. mansoni<\/jats:italic>\n                      intensity remains limited in the study area.\n                      <jats:italic>S. mansoni<\/jats:italic>\n                      diagnosis traditionally relies on the KK method, though the POC-CCA urine test offers a rapid alternative with high sensitivity. This study aimed to assess the prevalence and risk factors of\n                      <jats:italic>S. mansoni<\/jats:italic>\n                      and STH infections. It also evaluated the intensity of\n                      <jats:italic>S. mansoni<\/jats:italic>\n                      and compared the performance of the POC-CCA test to that of KK.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross-sectional study was conducted among schoolchildren in the Tulla district, Sidama region, from April to June 2024, using a purposive sampling approach. Data were collected through pre-structured questionnaires, and stool samples were analyzed using the KK method, while urine samples were analyzed with the POC-CCA technique. A logistic regression model was employed to examine potential associations between infections and risk factors, the Kappa statistic assessed agreement between tests, and the McNemar chi-square test compared the sensitivity and specificity of the diagnostic methods.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>\n                      The prevalence of\n                      <jats:italic>S. mansoni<\/jats:italic>\n                      with two combined tests was 36.5% (20.1% by KK and 34.4% by POC-CCA). Activities like irrigation, swimming, and bathing showed significant associations with\n                      <jats:italic>S. mansoni<\/jats:italic>\n                      infection. The prevalence of STH was 48.8%, with\n                      <jats:italic>A. lumbricoides<\/jats:italic>\n                      (34%) as the most common, followed by\n                      <jats:italic>T. trichuria<\/jats:italic>\n                      (8.2%), hookworm (5.7%),\n                      <jats:italic>Taenia<\/jats:italic>\n                      species (1.3%),\n                      <jats:italic>H<\/jats:italic>\n                      .\n                      <jats:italic>nana<\/jats:italic>\n                      (0.6%), and\n                      <jats:italic>E.vermicularis<\/jats:italic>\n                      (0.2%). Factors like hand washing, fingernail trimming, lack of latrines, and educational status were significantly linked to STH infections. The POC-CCA test demonstrated higher sensitivity (89.6%) than the KK technique (McNemar test \u03c7\u00b2m\u2009=\u200952.3, p\u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The moderate prevalence of\n                      <jats:italic>S. mansoni<\/jats:italic>\n                      and STH infections, coupled with socio-demographic factors, behaviours, hygiene practices, and sanitation issues associated with these infections, highlights the need for additional control measures beyond deworming. Implementing a highly sensitive POC- CCA test alongside the KK method in low-endemic areas could improve diagnostic accuracy and enhance disease management outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0337919","type":"journal-article","created":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T18:35:20Z","timestamp":1765564520000},"page":"e0337919","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Assessment of Schistosoma mansoni and soil-transmitted helminth infections and the diagnostic performance of the circulating cathodic antigen test among schoolchildren in Tulla district, Sidama region, Southern Ethiopia"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-6307-507X","authenticated-orcid":true,"given":"Fitsum","family":"Getachew","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Demissie","family":"Assegu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4144-8068","authenticated-orcid":true,"given":"Biniyam","family":"Kijineh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4380-9312","authenticated-orcid":true,"given":"Bamlaku","family":"Tadege","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2025,12,12]]},"reference":[{"key":"pone.0337919.ref001","first-page":"707","article-title":"Schistosomiasis and soil-transmitted helminthiases: 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