{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T18:14:32Z","timestamp":1788459272834,"version":"build-2803163510"},"reference-count":24,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Postoperative pain has significant impact on recovery and healthcare costs. While effective regional anesthesia provides both anesthesia and analgesia, its effects are often of limited duration. Previous studies indicate that intravenous dexamethasone may enhance and prolong analgesia when used with regional blocks, yet reports on its duration to supraclavicular brachial plexus block (SCBPB) for upper limb surgeries are limited. We hypothesized that intravenous dexamethasone would extend postoperative analgesia following SCBPB.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>A randomized clinical trial was conducted at Halibet National Referral Hospital in Eritrea, involving 60 patients undergoing upper limb surgery who received SCBPB with 20 ml of 0.5% bupivacaine. Concurrently, the control group received 2 ml of normal saline, while the experimental group received 2 ml (8 mg) of intravenous dexamethasone. Pain scores, time to first rescue analgesia, and analgesic consumption were recorded. Data were analyzed using SPSS v26.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The mean duration of analgesia was significantly longer in the dexamethasone group (17.36\u2009\u00b1\u20093.75 hours) compared to the control group (7.57\u2009\u00b1\u20091.04 hours, p\u2009&lt;\u20090.001). The dexamethasone group had faster onset of sensory and motor block and lower analgesic consumption.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In summary, intravenous dexamethasone significantly prolonged postoperative analgesia, accelerated block onset, and reduced analgesic consumption without adverse events. These findings support its use as a practical adjunct to bupivacaine in supraclavicular brachial plexus block, with potential to improve postoperative pain management in low\u2011resource settings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec005\">\n                    <jats:title>Clinical trial registration<\/jats:title>\n                    <jats:p>This trial was registered in the Pan African Clinical Trial Registry (PACTR202509579633417). Participant recruitment occurred between September 23, 2024 and January 17, 2025, with follow\u2011up completed by January 18, 2025. The authors confirm that all ongoing and related trials for this intervention are registered.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0338067","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T17:28:46Z","timestamp":1788456526000},"page":"e0338067","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["The effect of intravenous dexamethasone in supraclavicular brachial plexus block at Halibet National Referral Hospital, Eritrea 2024\u20132025: A randomized clinical trial"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4958-1876","authenticated-orcid":true,"given":"Michael Beraki","family":"Mengistu","sequence":"first","affiliation":[{"name":"Anesthesia Unit, Orotta College of Medicine and Health Sciences","place":["Asmara, Eritrea"],"department":["Department of Nursing"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senay Amare","family":"Habtu","sequence":"additional","affiliation":[{"name":"Anesthesia Unit, Orotta College of Medicine and Health Sciences","place":["Asmara, Eritrea"],"department":["Department of Nursing"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abel Mussie","family":"Elias","sequence":"additional","affiliation":[{"name":"Anesthesia Unit, Orotta College of Medicine and Health Sciences","place":["Asmara, Eritrea"],"department":["Department of Nursing"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina Hashim","family":"Idris","sequence":"additional","affiliation":[{"name":"Anesthesia Unit, Orotta College of Medicine and Health Sciences","place":["Asmara, Eritrea"],"department":["Department of Nursing"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kisanet Huruy","family":"Abraha","sequence":"additional","affiliation":[{"name":"Anesthesia Unit, Orotta College of Medicine and Health Sciences","place":["Asmara, Eritrea"],"department":["Department of Nursing"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,9,3]]},"reference":[{"key":"pone.0338067.ref001","volume-title":"Relieving pain in America: A blueprint for transforming prevention, care, education, and research","author":"Policy BOHS, COAP Research","year":"2011"},{"issue":"1","key":"pone.0338067.ref002","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1213\/01.ane.0000268145.52345.55","article-title":"Pain management: a fundamental human right","volume":"105","author":"F Brennan","year":"2007","journal-title":"Anesth Analg"},{"key":"pone.0338067.ref003","volume-title":"Relieving pain in America: A blueprint for transforming prevention, care, education, and research","author":"Institute of Medicine","year":"2011"},{"issue":"2","key":"pone.0338067.ref004","first-page":"57","article-title":"IV and 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