{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:53:53Z","timestamp":1791219233413,"version":"4.1.0"},"reference-count":65,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/W027925\/1"],"award-info":[{"award-number":["MR\/W027925\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/W002388\/1"],"award-info":[{"award-number":["MR\/W002388\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:p>People with chemotherapy-induced peripheral neuropathy (CIPN) have abnormalities in Quantitative Sensory Test (QST) findings. However, the predictive utility of QST for the early detection of CIPN in individuals has not been demonstrated. This will require longitudinal QST during chemotherapy treatments. However, QST is time-consuming, requires expertise and complex, costly equipment which has largely prevented its adoption in routine clinical practice. We aimed to assess approaches to develop a reliable, straightforward, time efficient and sensitive sensory testing method. Guided by patient partner input and previous literature, we selected thermal and vibration detection thresholds as target QST parameters. A series of iterative experiments was conducted to determine the optimal body test site and to develop a novel vibration testing protocol. The thenar eminence emerged as the best candidate due to higher sensitivity to all stimulus modalities, lower variance and less age-related change compared to the feet. We demonstrated significant differences in thermal thresholds between healthy participants and people with CIPN measured at the thenar but not the feet. The vibration testing protocol, employing a linear resonant actuator, performed better than a calibrated tuning fork being sufficiently sensitive to identify age-related and body site differences in sensory function well as tracking sensory loss induced by local anaesthetic nerve block. These findings establish a testing framework to deliver QST at a single convenient body site with a reduced set of modalities to efficiently track multifibre sensory function for patients at risk of developing neuropathy.<\/jats:p>","DOI":"10.1371\/journal.pone.0338105","type":"journal-article","created":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T18:35:22Z","timestamp":1764959722000},"page":"e0338105","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["Sense-checking the approach to quantitative sensory testing to detect chemotherapy-induced peripheral neuropathy"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1523-227X","authenticated-orcid":true,"given":"Marin","family":"Dujmovi\u0107","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James Philip","family":"Dunham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Gausden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bethany","family":"Groves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth Anne Cottuli","family":"de Cothi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Burgess","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Geddie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lottie","family":"Adams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Grant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nisla","family":"Maharjan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6711-975X","authenticated-orcid":true,"given":"Bhushan","family":"Thakkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1141-2161","authenticated-orcid":true,"given":"Anthony","family":"O\u2019Neill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Young","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger Graham","family":"Whittaker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lesley","family":"Colvin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony Edward","family":"Pickering","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2025,12,5]]},"reference":[{"issue":"4","key":"pone.0338105.ref001","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.ctrv.2008.01.003","article-title":"A review on oxaliplatin-induced peripheral nerve damage","volume":"34","author":"AA Argyriou","year":"2008","journal-title":"Cancer Treat Rev"},{"issue":"7","key":"pone.0338105.ref002","first-page":"1999","article-title":"A systematic review on chronic oxaliplatin-induced peripheral neuropathy and the relation with oxaliplatin administration","volume":"22","author":"AJM Beijers","year":"2014","journal-title":"Support Care Cancer"},{"key":"pone.0338105.ref003","doi-asserted-by":"crossref","first-page":"113121","DOI":"10.1016\/j.expneurol.2019.113121","article-title":"Pathogenesis of paclitaxel-induced peripheral neuropathy: A current review of in vitro and in vivo findings using rodent and human model systems","volume":"324","author":"NP Staff","year":"2020","journal-title":"Exp Neurol"},{"key":"pone.0338105.ref004","doi-asserted-by":"crossref","first-page":"152","DOI":"10.3390\/toxics3020152","article-title":"Taxane-Induced Peripheral Neurotoxicity","volume":"3","author":"R Velasco","year":"2015","journal-title":"Toxics"},{"key":"pone.0338105.ref005","doi-asserted-by":"crossref","DOI":"10.1111\/jns.12338","article-title":"Bortezomib and other proteosome inhibitors-induced peripheral neurotoxicity: From pathogenesis to treatment","volume":"24","author":"R Velasco","year":"2019","journal-title":"J Peripher Nerv Syst"},{"issue":"2","key":"pone.0338105.ref006","doi-asserted-by":"crossref","first-page":"888","DOI":"10.3390\/ijms22020888","article-title":"Pathological Mechanisms of Bortezomib-Induced Peripheral Neuropathy","volume":"22","author":"S Yamamoto","year":"2021","journal-title":"Int J Mol Sci"},{"key":"pone.0338105.ref007","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.neuro.2020.10.004","article-title":"Vincristine-induced peripheral neuropathy: A mini-review","volume":"81","author":"G-Z Li","year":"2020","journal-title":"Neurotoxicology"},{"key":"pone.0338105.ref008","first-page":"1231","article-title":"Vinca alkaloids","volume":"4","author":"M Moudi","year":"2013","journal-title":"Int J Prev Med"},{"key":"pone.0338105.ref009","doi-asserted-by":"crossref","DOI":"10.1097\/j.pain.0000000000001540","article-title":"Chemotherapy-induced peripheral neuropathy: where are we now?","volume":"160","author":"LA Colvin","year":"2019","journal-title":"Pain"},{"issue":"12","key":"pone.0338105.ref010","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1016\/j.pain.2014.09.020","article-title":"Incidence, prevalence, and predictors of chemotherapy-induced peripheral neuropathy: A systematic review and meta-analysis","volume":"155","author":"M Seretny","year":"2014","journal-title":"Pain"},{"issue":"5","key":"pone.0338105.ref011","article-title":"The experience of chemotherapy-induced peripheral neuropathy in adult cancer patients: a qualitative thematic synthesis","volume":"26","author":"MAL Tanay","year":"2017","journal-title":"Eur J Cancer Care (Engl)"},{"issue":"9","key":"pone.0338105.ref012","first-page":"4163","article-title":"Reporting of paclitaxel-induced peripheral neuropathy symptoms to clinicians among women with breast cancer: a qualitative study","volume":"28","author":"TM Salgado","year":"2020","journal-title":"Support Care Cancer"},{"issue":"1","key":"pone.0338105.ref013","article-title":"Clinician and patient experiences when providing and receiving information and support for managing chemotherapy-induced peripheral neuropathy: A qualitative multiple methods study","volume":"31","author":"MAL Tanay","year":"2022","journal-title":"Eur J Cancer Care (Engl)"},{"issue":"3","key":"pone.0338105.ref014","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/j.1529-8027.2007.00141.x","article-title":"The Total Neuropathy Score as an assessment tool for grading the course of chemotherapy-induced peripheral neurotoxicity: comparison with the National Cancer Institute-Common Toxicity Scale","volume":"12","author":"G Cavaletti","year":"2007","journal-title":"J Peripher Nerv Syst"},{"issue":"4","key":"pone.0338105.ref015","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1111\/j.1529-8027.2010.00292.x","article-title":"Measures of chemotherapy-induced peripheral neuropathy: a systematic review of psychometric properties","volume":"15","author":"KA Griffith","year":"2010","journal-title":"J Peripher Nerv Syst"},{"issue":"11","key":"pone.0338105.ref016","first-page":"3537","article-title":"Patient-reported (EORTC QLQ-CIPN20) versus physician-reported (CTCAE) quantification of oxaliplatin- and paclitaxel\/carboplatin-induced peripheral neuropathy in NCCTG\/Alliance clinical trials","volume":"25","author":"J Le-Rademacher","year":"2017","journal-title":"Support Care Cancer"},{"issue":"12","key":"pone.0338105.ref017","first-page":"4771","article-title":"Chemotherapy-induced peripheral neuropathy-patient-reported outcomes compared with NCI-CTCAE grade","volume":"27","author":"AC Tan","year":"2019","journal-title":"Support Care Cancer"},{"key":"pone.0338105.ref018","doi-asserted-by":"crossref","first-page":"2999","DOI":"10.1007\/s11136-017-1626-1","article-title":"Evaluation of the psychometric properties of the EORTC chemotherapy-induced peripheral neuropathy questionnaire (QLQ-CIPN20)","volume":"26","author":"In Collaboration with the CI-PeriNomS Group","year":"2017","journal-title":"Qual Life Res"},{"issue":"12","key":"pone.0338105.ref019","first-page":"4753","article-title":"Minimal clinically important difference of the EORTC QLQ-CIPN20 for worsening peripheral neuropathy in patients receiving neurotoxic chemotherapy","volume":"27","author":"F Yeo","year":"2019","journal-title":"Support Care Cancer"},{"issue":"11","key":"pone.0338105.ref020","first-page":"3485","article-title":"Optimal clinical assessment strategies for chemotherapy-induced peripheral neuropathy (CIPN): a systematic review and Delphi survey","volume":"25","author":"JM McCrary","year":"2017","journal-title":"Support Care Cancer"},{"issue":"9","key":"pone.0338105.ref021","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1016\/j.pain.2013.05.047","article-title":"Value of quantitative sensory testing in neurological and pain disorders: NeuPSIG consensus","volume":"154","author":"MM Backonja","year":"2013","journal-title":"Pain"},{"issue":"3","key":"pone.0338105.ref022","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.pain.2010.11.013","article-title":"Test-retest and interobserver reliability of quantitative sensory testing according to the protocol of the German Research Network on Neuropathic Pain (DFNS): a multi-centre study","volume":"152","author":"C Geber","year":"2011","journal-title":"Pain"},{"issue":"3","key":"pone.0338105.ref023","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.pain.2010.07.026","article-title":"Reference data for quantitative sensory testing (QST): refined stratification for age and a novel method for statistical comparison of group data","volume":"151","author":"W Magerl","year":"2010","journal-title":"Pain"},{"issue":"3","key":"pone.0338105.ref024","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.pain.2010.05.002","article-title":"Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): somatosensory abnormalities in 1236 patients with different neuropathic pain syndromes","volume":"150","author":"C Maier","year":"2010","journal-title":"Pain"},{"issue":"3","key":"pone.0338105.ref025","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.pain.2006.01.041","article-title":"Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): standardized protocol and reference values","volume":"123","author":"R Rolke","year":"2006","journal-title":"Pain"},{"issue":"3","key":"pone.0338105.ref026","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.pain.2009.03.024","article-title":"Thermal hyperalgesia as a marker of oxaliplatin neurotoxicity: a prospective quantified sensory assessment study","volume":"144","author":"N Attal","year":"2009","journal-title":"Pain"},{"issue":"4","key":"pone.0338105.ref027","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1111\/jns.12413","article-title":"Oxaliplatin- and docetaxel-induced polyneuropathy: clinical and neurophysiological characteristics","volume":"25","author":"K Bennedsgaard","year":"2020","journal-title":"J Peripher Nerv Syst"},{"issue":"21","key":"pone.0338105.ref028","doi-asserted-by":"crossref","first-page":"5955","DOI":"10.1158\/0008-5472.CAN-14-2060","article-title":"A quantitative sensory analysis of peripheral neuropathy in colorectal cancer and its exacerbation by oxaliplatin chemotherapy","volume":"74","author":"M de Carvalho Barbosa","year":"2014","journal-title":"Cancer Res"},{"issue":"4","key":"pone.0338105.ref029","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.jpain.2006.09.014","article-title":"Quantitative sensory findings in patients with bortezomib-induced pain","volume":"8","author":"JP Cata","year":"2007","journal-title":"J Pain"},{"key":"pone.0338105.ref030","first-page":"31","article-title":"Is quantitative sensory testing helpful in the management of oxaliplatin neuropathy? A two-year clinical study","volume":"17","author":"JB Delmotte","year":"2018","journal-title":"Cancer Treat Res Commun"},{"issue":"4","key":"pone.0338105.ref031","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1111\/ene.12353","article-title":"Characterization and diagnostic evaluation of chronic polyneuropathies induced by oxaliplatin and docetaxel comparing skin biopsy to quantitative sensory testing and nerve conduction studies","volume":"21","author":"T Kr\u00f8ig\u00e5rd","year":"2014","journal-title":"Eur J Neurol"},{"issue":"1","key":"pone.0338105.ref032","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/ene.14035","article-title":"Early changes in tests of peripheral nerve function during oxaliplatin treatment and their correlation with chemotherapy-induced polyneuropathy symptoms and signs","volume":"27","author":"T Kr\u00f8ig\u00e5rd","year":"2020","journal-title":"Eur J Neurol"},{"issue":"4","key":"pone.0338105.ref033","doi-asserted-by":"crossref","first-page":"679","DOI":"10.3233\/JND-210630","article-title":"Oxaliplatin Neuropathy: Predictive Values of Skin Biopsy, QST and Nerve Conduction","volume":"8","author":"T Kr\u00f8ig\u00e5rd","year":"2021","journal-title":"J Neuromuscul Dis"},{"issue":"4","key":"pone.0338105.ref034","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1002\/ejp.1520","article-title":"The use of quantitative sensory testing in cancer pain assessment: A systematic review","volume":"24","author":"ME Martland","year":"2020","journal-title":"Eur J Pain"},{"issue":"10","key":"pone.0338105.ref035","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1093\/pm\/pnaa192","article-title":"Reliability and Validity of the Boston Bedside Quantitative Sensory Testing Battery for Neuropathic Pain","volume":"21","author":"AE Koulouris","year":"2020","journal-title":"Pain Med"},{"issue":"1","key":"pone.0338105.ref036","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1097\/j.pain.0000000000003320","article-title":"Development and validation of a home quantitative sensory testing tool-kit to assess changes in sensory and pain processing: a study in healthy young adults","volume":"166","author":"DD Ocay","year":"2025","journal-title":"Pain"},{"issue":"3","key":"pone.0338105.ref037","article-title":"Sensory bedside testing: a simple stratification approach for sensory phenotyping","volume":"5","author":"M Reimer","year":"2020","journal-title":"Pain Rep"},{"issue":"1","key":"pone.0338105.ref038","article-title":"Test-retest reliability of a simple bedside-quantitative sensory testing battery for chronic neuropathic pain","volume":"8","author":"J Sachau","year":"2023","journal-title":"Pain Rep"},{"key":"pone.0338105.ref039","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/j.jpain.2019.11.013","article-title":"Test-Retest and Inter-Examiner Reliability of a Novel Bedside Quantitative Sensory Testing Battery in Postherpetic Neuralgia Patients","volume":"21","author":"AD Wasan","year":"2020","journal-title":"J Pain"},{"issue":"10","key":"pone.0338105.ref040","doi-asserted-by":"crossref","first-page":"986","DOI":"10.3113\/FAI.2009.0986","article-title":"Sensitivity mapping of the human foot: thresholds at 30 skin locations","volume":"30","author":"EM Hennig","year":"2009","journal-title":"Foot Ankle Int"},{"issue":"2","key":"pone.0338105.ref041","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3758\/BF03193146","article-title":"G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences","volume":"39","author":"F Faul","year":"2007","journal-title":"Behav Res Methods"},{"issue":"3","key":"pone.0338105.ref042","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1152\/japplphysiol.00158.2018","article-title":"Thermosensory micromapping of warm and cold sensitivity across glabrous and hairy skin of male and female hands and feet","volume":"125","author":"D Filingeri","year":"2018","journal-title":"J Appl Physiol (1985)"},{"issue":"1","key":"pone.0338105.ref043","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1080\/08990229870925","article-title":"Temperature sensitivity of the body surface over the life span","volume":"15","author":"JC Stevens","year":"1998","journal-title":"Somatosens Mot Res"},{"issue":"28","key":"pone.0338105.ref044","doi-asserted-by":"crossref","first-page":"3325","DOI":"10.1200\/JCO.20.01399","article-title":"Prevention and Management of Chemotherapy-Induced Peripheral Neuropathy in Survivors of Adult Cancers: ASCO Guideline Update","volume":"38","author":"CL Loprinzi","year":"2020","journal-title":"J Clin Oncol"},{"issue":"4","key":"pone.0338105.ref045","first-page":"235","article-title":"Chemotherapy-induced polyneuropathy in cancer care-the patient perspective","volume":"31","author":"K Prager","year":"2023","journal-title":"Support Care Cancer"},{"issue":"1","key":"pone.0338105.ref046","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1186\/s12885-019-6352-3","article-title":"Redefining chemotherapy-induced peripheral neuropathy through symptom cluster analysis and patient-reported outcome data over time","volume":"19","author":"M Wang","year":"2019","journal-title":"BMC Cancer"},{"issue":"6","key":"pone.0338105.ref047","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.3390\/ijms20061451","article-title":"Mechanisms of Chemotherapy-Induced Peripheral Neuropathy","volume":"20","author":"R Zaj\u0105czkowska","year":"2019","journal-title":"Int J Mol Sci"},{"issue":"12","key":"pone.0338105.ref048","doi-asserted-by":"crossref","first-page":"4481","DOI":"10.1007\/s10072-023-06929-z","article-title":"Age-, gender- and body site-specific reference values of thermal Quantitative Sensory Testing in the Italian population using the Q-sense device","volume":"44","author":"G Cosentino","year":"2023","journal-title":"Neurol Sci"},{"issue":"1","key":"pone.0338105.ref049","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S1388-2457(99)00192-3","article-title":"Quantitative sensory testing: effect of site and skin temperature on thermal thresholds","volume":"111","author":"LG Hagander","year":"2000","journal-title":"Clin Neurophysiol"},{"key":"pone.0338105.ref050","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.cnp.2018.06.004","article-title":"Method-of-limits; Cold and warm perception thresholds at proximal and distal body regions","volume":"3","author":"V Heldestad Lilliesk\u00f6ld","year":"2018","journal-title":"Clin Neurophysiol Pract"},{"issue":"18","key":"pone.0338105.ref051","doi-asserted-by":"crossref","first-page":"2658","DOI":"10.1016\/j.ejca.2007.07.030","article-title":"Pain in oxaliplatin-induced neuropathy--sensitisation in the peripheral and central nociceptive system","volume":"43","author":"A Binder","year":"2007","journal-title":"Eur J Cancer"},{"issue":"3","key":"pone.0338105.ref052","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/s00280-012-2047-z","article-title":"Persistent chemoneuropathy in patients receiving the plant alkaloids paclitaxel and vincristine","volume":"71","author":"JA Boyette-Davis","year":"2013","journal-title":"Cancer Chemother Pharmacol"},{"issue":"2","key":"pone.0338105.ref053","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.jpainsymman.2006.08.006","article-title":"Dysfunction in multiple primary afferent fiber subtypes revealed by quantitative sensory testing in patients with chronic vincristine-induced pain","volume":"33","author":"PM Dougherty","year":"2007","journal-title":"J Pain Symptom Manage"},{"key":"pone.0338105.ref054","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.pain.2004.01.021","article-title":"Taxol-induced sensory disturbance is characterized by preferential impairment of myelinated fiber function in cancer patients","volume":"109","author":"PM Dougherty","year":"2004","journal-title":"Pain"},{"issue":"9","key":"pone.0338105.ref055","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1093\/pm\/pnx231","article-title":"Chronic Pain and Neuropathy Following Adjuvant Chemotherapy","volume":"19","author":"L Ventzel","year":"2018","journal-title":"Pain Med"},{"issue":"1","key":"pone.0338105.ref056","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.arr.2010.04.009","article-title":"Thermal sensitivity in the elderly: a review","volume":"10","author":"S Guergova","year":"2011","journal-title":"Ageing Res Rev"},{"key":"pone.0338105.ref057","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.jocn.2009.10.003","article-title":"Influence of age on thermal thresholds, thermal pain thresholds, and reaction time","volume":"17","author":"H-W Huang","year":"2010","journal-title":"J Clin Neurosci"},{"key":"pone.0338105.ref058","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1002\/(SICI)1097-0274(199811)34:5<438::AID-AJIM4>3.0.CO;2-M","article-title":"Effect of age and height on vibrotactile threshold among 1,663 U.S. workers","volume":"34","author":"T Skov","year":"1998","journal-title":"Am J Ind Med"},{"key":"pone.0338105.ref059","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2318-3-1","article-title":"Effects of aging on vibration detection thresholds at various body regions","volume":"3","author":"M Stuart","year":"2003","journal-title":"BMC Geriatr"},{"issue":"2","key":"pone.0338105.ref060","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/geronj\/35.2.185","article-title":"Age related changes in the sensitivity to vibration","volume":"35","author":"RT Verrillo","year":"1980","journal-title":"J Gerontol"},{"issue":"8","key":"pone.0338105.ref061","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1093\/gerona\/58.8.B680","article-title":"Regional variation and changes with ageing in vibrotactile sensitivity in the human footsole","volume":"58","author":"C Wells","year":"2003","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"2","key":"pone.0338105.ref062","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1152\/physrev.1954.34.2.259","article-title":"Determinants of the critical flicker-fusion threshold","volume":"34","author":"C Landis","year":"1954","journal-title":"Physiol Rev"},{"issue":"4","key":"pone.0338105.ref063","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1152\/jn.00313.2020","article-title":"Tactile innervation densities across the whole body","volume":"124","author":"G Corniani","year":"2020","journal-title":"J Neurophysiol"},{"issue":"3","key":"pone.0338105.ref064","doi-asserted-by":"crossref","first-page":"325","DOI":"10.5115\/acb.20.105","article-title":"Re-evaluation of the distribution of Meissner\u2019s corpuscles in human skin","volume":"53","author":"SH Kim","year":"2020","journal-title":"Anat Cell Biol"},{"issue":"2","key":"pone.0338105.ref065","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1080\/08990220802045574","article-title":"Vibrotactile thresholds at the fingertip, volar forearm, large toe, and heel","volume":"25","author":"M Morioka","year":"2008","journal-title":"Somatosens Mot Res"}],"container-title":["PLOS One"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0338105","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T18:35:31Z","timestamp":1764959731000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0338105"}},"subtitle":[],"editor":[{"given":"Armando","family":"Almeida","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,12,5]]},"references-count":65,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2025,12,5]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0338105","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,5]]}}}