{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T18:38:35Z","timestamp":1777055915140,"version":"3.51.4"},"reference-count":27,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Japan Agency for Medical Research and Development Grant","award":["18ae0101011h005"],"award-info":[{"award-number":["18ae0101011h005"]}]},{"name":"Project for Cancer Research and Therapeutic Evolution","award":["JP20cm0106402"],"award-info":[{"award-number":["JP20cm0106402"]}]},{"name":"National Cancer Center Research and Development Fund","award":["2023-J-02"],"award-info":[{"award-number":["2023-J-02"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"\n Compared with transplanted tumors, autochthonous tumors are difficult to cure using experimental radiation therapy in mice. Here we analyzed differences in immune-related gene expression profiles between mouse fibrosarcomas subcutaneously induced by 3-methylcholanthrene (3MC) and their corresponding transplanted tumors. The immune genes examined were\n Pd1<\/jats:italic>\n ,\n Pdl1<\/jats:italic>\n ,\n Pdl2<\/jats:italic>\n ,\n Cd3d<\/jats:italic>\n ,\n Cd8a<\/jats:italic>\n ,\n Cd8b<\/jats:italic>\n ,\n Ifn\u03b3<\/jats:italic>\n ,\n Itga2<\/jats:italic>\n ,\n Gzmb,<\/jats:italic>\n and\n Foxp3<\/jats:italic>\n . Among 12 tumors, one was non-transplantable and showed a benign phenotype with an abundance of DX5\n +<\/jats:sup>\n natural killer cells and CD8\n +<\/jats:sup>\n T cells together with increased IFN\u03b3 expression and mRNA levels of all immune genes except for\n Itga2<\/jats:italic>\n . The other 11 transplantable tumors showed increased expression of\n Pd1<\/jats:italic>\n ,\n Pdl1<\/jats:italic>\n ,\n Pdl2<\/jats:italic>\n ,\n Cd3d<\/jats:italic>\n ,\n Cd8b<\/jats:italic>\n , and\n Ifn\u03b3<\/jats:italic>\n following transplantation into syngeneic mice. These effects of transplantation highlight the relevance of immune gene expression status to the curability of tumors.\n <\/jats:p>","DOI":"10.1371\/journal.pone.0338289","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T17:47:02Z","timestamp":1777052822000},"page":"e0338289","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Curability difference between autochthonous mouse tumors and their transplants in association with immune gene expression"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5167-3756","authenticated-orcid":true,"given":"Hiroshi","family":"Tanooka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chie","family":"Kudo-Saito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumiko","family":"Chiwaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masamichi","family":"Ishiai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kouichi","family":"Tatsumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Ochiya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2026,4,24]]},"reference":[{"key":"pone.0338289.ref001","first-page":"380","volume-title":"Radiobiology for the radiologist. 8th ed. 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