{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T18:29:55Z","timestamp":1765909795670,"version":"3.48.0"},"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T00:00:00Z","timestamp":1765843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Epiretinal membrane is a common retinal condition, particularly in the elderly, than can lead to reduced visual acuity and visual distortion. Structural optical coherence tomography biomarkers have shown potential for predicting visual outcomes following surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the prognostic value of baseline structural optical coherence tomography biomarkers for visual outcomes following epiretinal membrane surgery. We will assess associations between individual biomarkers and postoperative visual acuity or changes in visual acuity at 6, 12, and 24 months after surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We will systematically search MEDLINE, EMBASE, CENTRAL and Web of Science from inception. Eligible studies will include randomized trials and observational studies reporting the association between any baseline optical coherence tomography biomarkers and postoperative visual acuity in patients undergoing epiretinal membrane surgery. Two reviewers will independently and in duplicate perform screening, data extraction, and risk of bias assessment. Meta-analyses using the restricted maximum likelihood random-effects model will be conducted whenever possible. The certainty of evidence for each estimate will be assessed using the GRADE approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Expected outcomes<\/jats:title>\n                    <jats:p>This review will analyze time-specific association between baseline structural optical coherence tomography biomarkers and postoperative visual acuity and change in visual acuity from baseline at 6, 12, and 24 months after surgery, quality of life measured using any validated scale, and adverse events.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0338330","type":"journal-article","created":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T18:26:09Z","timestamp":1765909569000},"page":"e0338330","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["OphthoEvidence report: Baseline structural optical coherence tomography biomarkers predictive of visual acuity following epiretinal membrane surgery\u2013A systematic review and meta-analysis protocol"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6283-8074","authenticated-orcid":true,"given":"Xiajing","family":"Chu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5486-7211","authenticated-orcid":true,"given":"Jo\u00e3o Pedro","family":"Lima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dena","family":"Zeraatkar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinhui","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5445-2489","authenticated-orcid":true,"given":"Femin","family":"Prasad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sangeetha","family":"Srinivasan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8952-0659","authenticated-orcid":true,"given":"Sobha","family":"Sivaprasad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Sandinha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Kaiser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David H.","family":"Steel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tien Yin","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles C.","family":"Wykoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9988-4146","authenticated-orcid":true,"given":"Varun","family":"Chaudhary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2025,12,16]]},"reference":[{"key":"pone.0338330.ref001"},{"key":"pone.0338330.ref002","first-page":"161","article-title":"The impact of optical coherence tomography on surgical decision making in epiretinal membrane and vitreomacular traction","volume":"104","author":"DV Do","year":"2006","journal-title":"Trans Am Ophthalmol 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