{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T21:10:48Z","timestamp":1765228248796,"version":"3.46.0"},"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T00:00:00Z","timestamp":1765152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"\n Background<\/jats:title>\n In Ethiopia, the incidence rate of tuberculosis (TB) has been steadily increasing, from 119 per 100,000 in 2021\u2013126 per 100,000 in 2022 and 146 per 100,000 in 2023. Moreover, TB remains the second leading cause of death after malaria, and the third leading cause of hospital admissions. So, the aim of this study is to determine the treatment outcome and associated factors in the public health institutions of Arba Minch town.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A multi-centered retrospective cross-sectional study was conducted involving 609 tuberculosis patients admitted from September 2021-August 2024 at public health institutions in Arba Minch town. A structured data extraction form was used by trained research assistants to collect the data from TB patient registration record books. Variables with a p-value <0.25 in binary logistic regression were further analyzed using multivariable logistic regression. Statistically significant factors were considered those with a p-value <0.05.<\/jats:p>\n <\/jats:sec>\n \n Result<\/jats:title>\n The majority (53.7%) of the participants were aged between 21 and 40 years. Most participants were diagnosed with pulmonary tuberculosis (71.8%) and found to be new (92.9%) patients. According to this study, the magnitude of successful treatment outcomes was found to be 86.9%. In the multivariate logistic regression, being unmarried (p\u2009=\u20090.023), educational level (p\u2009=\u20090.028), and having extra-pulmonary TB (p\u2009=\u20090.017) have been found significantly associated with successful treatment outcome.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n The study indicates a relatively positive rate of successful treatment outcomes for TB. Although the treatment outcome results are positive, targeted interventions are needed for individuals who are married, have a low educational status, and have been diagnosed with pulmonary tuberculosis.<\/jats:p>\n <\/jats:sec>","DOI":"10.1371\/journal.pone.0338393","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T18:25:47Z","timestamp":1765218347000},"page":"e0338393","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Magnitude of tuberculosis treatment outcomes and associated factors in public health institutions of Arba Minch town, Southern Ethiopia: A multi-centered retrospective cross-sectional study"],"prefix":"10.1371","volume":"20","author":[{"given":"Behailu","family":"Asmamaw","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1609-9385","authenticated-orcid":true,"given":"Temesgen Tamiru","family":"Tadese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rediet Yifru","family":"Mamo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berhanu Amare","family":"Taye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abrham Workineh","family":"Azale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yohannes Chemere","family":"Wondmeneh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dagmawi Nega","family":"Shibeshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8259-9203","authenticated-orcid":true,"given":"Eunice Borkor","family":"Bortequaye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Temesgen Teklu","family":"Ziza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Temesgen Esayas","family":"Bolliso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4200-4216","authenticated-orcid":true,"given":"Tiwabwork","family":"Tekalign","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2753-4216","authenticated-orcid":true,"given":"Awoke","family":"Guadie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2025,12,8]]},"reference":[{"key":"pone.0338393.ref001","volume-title":"Global tuberculosis report 2024","author":"World Health Organization","year":"2024","edition":"1"},{"issue":"12","key":"pone.0338393.ref002","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1016\/S1473-3099(23)00372-9","article-title":"Burden of tuberculosis among vulnerable populations worldwide: an overview of systematic reviews","volume":"23","author":"S Litvinjenko","year":"2023","journal-title":"Lancet Infect Dis"},{"issue":"1","key":"pone.0338393.ref003","article-title":"Tuberculosis treatment outcomes and associated factors among patients treated at Bosaso TB Hospital, Bosaso, Somalia: A five-year retrospective study","volume":"20","author":"SS Jama","year":"2025","journal-title":"PLoS One"},{"key":"pone.0338393.ref004","volume-title":"Guidelines for clinical and programmatic management of TB, TB\/HIV, DR-TB and leprosy in Ethiopia","author":"Federal Ministry of Health (FMOH), Ethiopia","year":"2021"},{"key":"pone.0338393.ref005","volume-title":"Tuberculosis profile: Ethiopia","author":"World Health Organization","year":"2024"},{"key":"pone.0338393.ref006","volume-title":"Leprosy and TB\/HIV Prevention and Control Programme Manual","author":"FMOH, Ethiopia","year":"2008"},{"issue":"20","key":"pone.0338393.ref007","doi-asserted-by":"crossref","first-page":"10678","DOI":"10.3390\/ijerph182010678","article-title":"Tuberculosis Treatment Outcome and Predictors in Africa: A Systematic Review and Meta-Analysis","volume":"18","author":"MY Teferi","year":"2021","journal-title":"Int J Environ Res Public Health"},{"key":"pone.0338393.ref008","first-page":"1503219","article-title":"Tuberculosis Treatment Outcomes and Associated Factors among TB Patients Attending Public Hospitals in Harar Town, Eastern Ethiopia: A Five-Year Retrospective Study","volume":"2019","author":"A Tola","year":"2019","journal-title":"Tuberc Res Treat"},{"key":"pone.0338393.ref009","doi-asserted-by":"crossref","first-page":"3367","DOI":"10.2147\/IDR.S413272","article-title":"Tuberculosis Treatment Outcome and Associated Factors Among Tuberculosis Patients Linked to Tuberculosis Treatment Clinics in Ethiopia, 2023: A Multi-Center Retrospective Study","volume":"16","author":"A Berhan","year":"2023","journal-title":"Infect Drug Resist"},{"issue":"3","key":"pone.0338393.ref010","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.4081\/jphr.2021.2046","article-title":"Tuberculosis treatment outcome and associated factors among tuberculosis patients at Wolayta Sodo Teaching and Referral Hospital, Southern Ethiopia: a retrospective study","volume":"10","author":"MY Teferi","year":"2021","journal-title":"J Public Health Res"},{"issue":"1","key":"pone.0338393.ref011","doi-asserted-by":"crossref","DOI":"10.4172\/1948-593X.1000200","article-title":"Factors Affecting Treatment Outcome of Tuberculosis among Tuberculosis Patients in West Ethiopia","volume":"10","author":"JI Kassa","year":"2018","journal-title":"J Bioanal Biomed"},{"issue":"3","key":"pone.0338393.ref012","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgph.0000161","article-title":"Poor adult tuberculosis treatment outcome and associated factors in Gibe Woreda, Southern Ethiopia: An institution-based cross-sectional study","volume":"2","author":"MM Mengesha","year":"2022","journal-title":"PLOS Glob Public Health"},{"key":"pone.0338393.ref013","doi-asserted-by":"crossref","first-page":"1406211","DOI":"10.3389\/fpubh.2024.1406211","article-title":"Determinants of unsuccessful tuberculosis treatment outcome in Southwest Ethiopia regional state public hospitals, 2022: a multi-center case control study","volume":"12","author":"S Berihe Hiluf","year":"2024","journal-title":"Front Public Health"},{"issue":"9979","key":"pone.0338393.ref014","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1016\/S0140-6736(15)60570-0","article-title":"WHO\u2019s new end TB strategy","volume":"385","author":"M Uplekar","year":"2015","journal-title":"Lancet"},{"key":"pone.0338393.ref015","author":"Ethiopian Central Statistics Authority (CSA)"},{"key":"pone.0338393.ref016","volume-title":"Treatment of tuberculosis: guidelines","author":"World Health Organization","year":"2010","edition":"4"},{"issue":"1","key":"pone.0338393.ref017","doi-asserted-by":"crossref","first-page":"7695","DOI":"10.1038\/s41598-024-58080-0","article-title":"Tuberculosis treatment outcomes and associated factors among tuberculosis patients treated at healthcare facilities of Motta Town, Northwest Ethiopia: a five-year retrospective study","volume":"14","author":"LW Limenh","year":"2024","journal-title":"Sci Rep"},{"issue":"1","key":"pone.0338393.ref018","article-title":"Prevalence of tuberculosis in Sub-Saharan Africa","volume":"2022","author":"B Heaton","year":"2022","journal-title":"Ballard Brief"},{"issue":"3","key":"pone.0338393.ref019","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.ijtb.2020.02.005","article-title":"A systemic review on tuberculosis","volume":"67","author":"A Natarajan","year":"2020","journal-title":"Indian J Tuberc"},{"key":"pone.0338393.ref020","first-page":"1354356","article-title":"Treatment Outcome and Associated Factors among Tuberculosis Patients in Debre Tabor, Northwestern Ethiopia: A Retrospective Study","volume":"2016","author":"A Melese","year":"2016","journal-title":"Tuberc Res Treat"},{"key":"pone.0338393.ref021","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/8504629","article-title":"Treatment Outcomes of Tuberculosis and Associated Factors in an Ethiopian University Hospital","volume":"2016","author":"M Biruk","year":"2016","journal-title":"Adv Public Health"},{"key":"pone.0338393.ref022","doi-asserted-by":"crossref","first-page":"3423","DOI":"10.2147\/IDR.S275568","article-title":"Tuberculosis Treatment Outcomes and Associated Factors Among Patients Treated at Woldia General Hospital in Northeast Ethiopia: An Institution-Based Cross-Sectional Study","volume":"13","author":"A Getie","year":"2020","journal-title":"Infect Drug Resist"},{"issue":"6","key":"pone.0338393.ref023","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.bjid.2016.07.012","article-title":"Tuberculosis treatment outcome and associated factors among smear-positive pulmonary tuberculosis patients in Afar, Eastern Ethiopia: a retrospective study","volume":"20","author":"T Zenebe","year":"2016","journal-title":"Braz J Infect Dis"},{"issue":"1","key":"pone.0338393.ref024","doi-asserted-by":"crossref","first-page":"35","DOI":"10.4103\/ijmy.ijmy_177_18","article-title":"Treatment outcomes and associated factors in tuberculosis patients at Jimma University Medical Center: A 5-year retrospective study","volume":"8","author":"G Abebe","year":"2019","journal-title":"Int J Mycobacteriol"},{"key":"pone.0338393.ref025","first-page":"726193","article-title":"Treatment outcome of tuberculosis patients at enfraz health center, northwest ethiopia: a five-year retrospective study","volume":"2014","author":"M Endris","year":"2014","journal-title":"Tuberc Res Treat"},{"issue":"6","key":"pone.0338393.ref026","doi-asserted-by":"crossref","first-page":"315","DOI":"10.3390\/tropicalmed8060315","article-title":"Treatment Outcomes and Associated Factors among Tuberculosis Patients from Selected Rural Eastern Cape Hospitals: An Ambidirectional Study","volume":"8","author":"LM Faye","year":"2023","journal-title":"Trop Med Infect Dis"},{"issue":"10","key":"pone.0338393.ref027","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1111\/tmi.13467","article-title":"Tuberculosis treatment outcomes and associated factors in two states in Nigeria","volume":"25","author":"A Matthew Adebayo","year":"2020","journal-title":"Trop Med Int Health"},{"key":"pone.0338393.ref028","first-page":"49","article-title":"Factors associated with tuberculosis treatment outcomes among tuberculosis patients attending tuberculosis treatment centers in Mogadishu, Somalia, 2016\u20132017","volume":"30","author":"HM Ali","year":"2018","journal-title":"Pan Afr Med J"},{"issue":"3","key":"pone.0338393.ref029","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1111\/tmi.13720","article-title":"Risk factors associated with unsuccessful tuberculosis treatment outcomes in Hunan Province, China","volume":"27","author":"B Gilmour","year":"2022","journal-title":"Trop Med Int Health"},{"issue":"3","key":"pone.0338393.ref030","doi-asserted-by":"crossref","first-page":"452","DOI":"10.4103\/jfmpc.jfmpc_1331_22","article-title":"Treatment outcomes and associated factors among patients with drug-sensitive tuberculosis on daily fixed-dose combination drugs: A cohort study from Ahmedabad, India","volume":"12","author":"AC Prajapati","year":"2023","journal-title":"J Family Med Prim Care"},{"key":"pone.0338393.ref031","first-page":"9952806","article-title":"Treatment Outcomes and Associated Factors in Tuberculosis Patients at Atwima Nwabiagya District, Ashanti Region, Ghana: A Ten-Year Retrospective Study","volume":"2021","author":"SA Agyare","year":"2021","journal-title":"Tuberc Res Treat"},{"issue":"7","key":"pone.0338393.ref032","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2022-062857","article-title":"Treatment outcomes and associated factors among patients with multidrug-resistant tuberculosis in Ashanti Region, Ghana: a retrospective, cross-sectional study","volume":"12","author":"V Panford","year":"2022","journal-title":"BMJ Open"},{"key":"pone.0338393.ref033","doi-asserted-by":"crossref","first-page":"1105911","DOI":"10.3389\/fmed.2023.1105911","article-title":"Treatment outcomes and associated factors among tuberculosis patients attending Gurage Zone Public Hospital, Southern Nations, Nationalities, and People\u2019s Region, Ethiopia: an institution-based cross-sectional study","volume":"10","author":"HW Agazhu","year":"2023","journal-title":"Front Med (Lausanne)"},{"issue":"1","key":"pone.0338393.ref034","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1186\/s12889-020-09827-7","article-title":"Level of and associated factors for non-adherence to anti-tuberculosis treatment among tuberculosis patients in Gamo Gofa zone, southern Ethiopia: cross-sectional study","volume":"20","author":"D Ajema","year":"2020","journal-title":"BMC Public Health"},{"key":"pone.0338393.ref035","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.2147\/NDT.S424694","article-title":"The Relationship Between Level of Education, Cognitive Function and Medication Adherence in Patients with Schizophrenia","volume":"19","author":"X Zhu","year":"2023","journal-title":"Neuropsychiatr Dis Treat"},{"issue":"3","key":"pone.0338393.ref036","doi-asserted-by":"crossref","DOI":"10.1016\/j.jval.2016.03.751","article-title":"The Impact of Demographic And Socio-Economic Factors on Medication Adherence","volume":"19","author":"K Kilgore","year":"2016","journal-title":"Value in Health"},{"issue":"2","key":"pone.0338393.ref037","first-page":"45","article-title":"Medication adherence and its predictors among patients with chronic illness in nursing and midwifery settings","volume":"7","author":"EA Basha","year":"2018","journal-title":"Nurs Midwifery Stud"},{"issue":"4","key":"pone.0338393.ref038","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0232134","article-title":"Extrapulmonary tuberculosis in Pakistan- A nation-wide multicenter retrospective study","volume":"15","author":"S Tahseen","year":"2020","journal-title":"PLoS One"},{"issue":"11","key":"pone.0338393.ref039","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0187585","article-title":"Estimating the impact of tuberculosis anatomical classification on treatment outcomes: A patient and surveillance perspective analysis","volume":"12","author":"OT Ranzani","year":"2017","journal-title":"PLoS One"}],"container-title":["PLOS One"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0338393","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T18:25:54Z","timestamp":1765218354000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0338393"}},"subtitle":[],"editor":[{"given":"Frederick","family":"Quinn,","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2025,12,8]]},"references-count":39,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2025,12,8]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0338393","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,8]]}}}