{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T13:15:05Z","timestamp":1791465305606,"version":"4.3.4"},"reference-count":65,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Stafford Fox Medical Research Foundation","award":["489798"],"award-info":[{"award-number":["489798"]}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1199502"],"award-info":[{"award-number":["1199502"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100032041","name":"The Mason Foundation","doi-asserted-by":"crossref","award":["47107"],"award-info":[{"award-number":["47107"]}],"id":[{"id":"10.13039\/100032041","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100014834","name":"The McCusker Charitable Foundation","doi-asserted-by":"crossref","award":["49979"],"award-info":[{"award-number":["49979"]}],"id":[{"id":"10.13039\/100014834","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Talei Stewart"},{"name":"The Buxton Foundation","award":["4676"],"award-info":[{"award-number":["4676"]}]},{"name":"Henty Community","award":["4879"],"award-info":[{"award-number":["4879"]}]},{"name":"Blake Beckett Trust Foundation","award":["4579"],"award-info":[{"award-number":["4579"]}]},{"name":"Alison Hunter Memorial Foundation","award":["4570"],"award-info":[{"award-number":["4570"]}]},{"name":"The Change for ME Charity","award":["4575"],"award-info":[{"award-number":["4575"]}]},{"name":"Dr John Hamwood"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome (ME\/CFS) is a disabling chronic illness. Many people with ME\/CFS (pwME\/CFS) are unable to continue employment and require support to complete activities of daily living. Despite this, ME\/CFS remains unrecognised as a disability in Australia. The present study aimed to highlight the profound burdens experienced by pwME\/CFS over time to provide evidence of permanency and necessitate reforms to Australian healthcare policies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Data were collected for this longitudinal investigation between 1\n                      <jats:sup>st<\/jats:sup>\n                      October 2021 and 3\n                      <jats:sup>rd<\/jats:sup>\n                      October 2024. All participants were Australian residents aged between 18 and 65 years fulfilling the Canadian or International Consensus Criteria. Sociodemographic information, medical history, illness presentation and patient-reported outcomes were collected using three self-administered questionnaires distributed at approximately six-month intervals. Illness presentation and patient-reported outcomes were investigated over 12 months with Cochran\u2019s\n                      <jats:italic>Q<\/jats:italic>\n                      , Friedman and one-way repeated measures ANOVA tests using Statistical Package for the Social Sciences version 29.0. Quality of life data were compared with Australian population norms using one-sample Wilcoxon signed-rank tests.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirty-two pwME\/CFS (n\u2009=\u200922\/32, 68.8% female) participated at all three time points. At baseline, the mean age was 44.03 years and median illness duration was 12.50 years. Participants reported a median of 30 symptoms at each time point \u2014 the most common of which were also the most severe in presentation. Importantly, there were no significant changes in any symptom or patient-reported outcome over the 12-month study period. Overall health status, physical health and the ability to participate in daily and work life activities were the most substantially impacted. Quality of life was significantly reduced among pwME\/CFS when compared with population norms at all time points.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PwME\/CFS face substantial and sustained illness burdens. These consistent, profound impairments emphasise the need for improved access to disability and social support services for pwME\/CFS in Australia through policy reform.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0338433","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T18:36:37Z","timestamp":1767033397000},"page":"e0338433","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["Sustained illness burden over time among Australians with myalgic encephalomyelitis\/chronic fatigue 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University","year":"2018"},{"key":"pone.0338433.ref030","volume-title":"National Statement on Ethical Conduct in Human Research","author":"National Health and Medical Research Council, Australian Research Council, Universities Australia","year":"2023"},{"issue":"20","key":"pone.0338433.ref031","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1001\/jama.2013.281053","article-title":"World Medical Association Declaration of Helsinki: Ethical principles for medical research involving human subjects","volume":"310","author":"World Medical Association","year":"2013","journal-title":"JAMA"},{"issue":"4","key":"pone.0338433.ref032","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.jclinepi.2007.11.008","article-title":"The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies","volume":"61","author":"E Von Elm","year":"2008","journal-title":"J Clin Epidemiol"},{"issue":"1","key":"pone.0338433.ref033","doi-asserted-by":"crossref","DOI":"10.1186\/1472-684X-4-7","article-title":"The Australia-modified Karnofsky Performance Status (AKPS) scale: a revised scale for contemporary palliative care clinical practice","volume":"4","author":"AP Abernethy","year":"2005","journal-title":"BMC Palliat Care"},{"key":"pone.0338433.ref034","volume-title":"The doctor\u2019s guide to chronic fatigue syndrome: Understanding, treating, and living with CFIDS","author":"DS Bell","year":"1995"},{"key":"pone.0338433.ref035","volume-title":"Fatigue and multiple sclerosis: Evidence-based management strategies for fatigue in multiple sclerosis","author":"Paralyzed Veterans of America","year":"1998"},{"key":"pone.0338433.ref036","volume-title":"Measuring health and disability: Manual for WHO Disability Assessment Schedule (WHODAS 2.0)","author":"World Health Organization","year":"2010"},{"issue":"1","key":"pone.0338433.ref037","doi-asserted-by":"crossref","DOI":"10.1186\/1478-7954-3-8","article-title":"Psychometric properties of the CDC Symptom Inventory for assessment of Chronic Fatigue Syndrome","volume":"3","author":"D Wagner","year":"2005","journal-title":"Popul Health Metrics"},{"issue":"24","key":"pone.0338433.ref038","doi-asserted-by":"crossref","first-page":"3130","DOI":"10.1097\/00007632-200012150-00008","article-title":"SF-36 health survey update","volume":"25","author":"JE Ware","year":"2000","journal-title":"Spine (Phila Pa 1976)"},{"issue":"5","key":"pone.0338433.ref039","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1002\/acr.20140","article-title":"The American College of Rheumatology preliminary diagnostic criteria for fibromyalgia and measurement of symptom severity","volume":"62","author":"F Wolfe","year":"2010","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"pone.0338433.ref040","doi-asserted-by":"crossref","first-page":"103208","DOI":"10.1016\/j.jbi.2019.103208","article-title":"The REDCap consortium: Building an international community of software platform partners","volume":"95","author":"PA Harris","year":"2019","journal-title":"J Biomed Inform"},{"issue":"2","key":"pone.0338433.ref041","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jbi.2008.08.010","article-title":"Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support","volume":"42","author":"PA Harris","year":"2009","journal-title":"J Biomed Inform"},{"key":"pone.0338433.ref042","volume-title":"IBM Statistical Package for the Social Sciences, Version 29.0","author":"IBM Corp","year":"2022"},{"key":"pone.0338433.ref043","article-title":"Basic statistical recording for articles published in biomedical journals: \u201cThe Statistical Analyses and Methods in the Published Literature\u201d or \u201cThe SAMPL Guidelines.\u201d.","volume-title":"Science Editor\u2019s Handbook","author":"TA Lang","year":"2013","edition":"2"},{"key":"pone.0338433.ref044","doi-asserted-by":"crossref","first-page":"184","DOI":"10.5005\/jp-journals-10071-23815","article-title":"An Introduction to Statistics: Choosing the Correct Statistical Test","volume":"25","author":"P Ranganathan","year":"2021","journal-title":"Indian J Crit Care Med"},{"issue":"2","key":"pone.0338433.ref045","first-page":"96","article-title":"Ranking ordinal scales using the consensus measure","volume":"6","author":"WJ Tastle","year":"2005","journal-title":"IIS"},{"key":"pone.0338433.ref046","volume-title":"SF-36: Interim norms for Australian data","author":"C Stevenson","year":"1996"},{"issue":"12","key":"pone.0338433.ref047","article-title":"Internal consistency: from alpha to omega?","volume":"142","author":"K Stensen","year":"2022","journal-title":"Tidsskr Nor Laegeforen"},{"key":"pone.0338433.ref048","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1186\/s12967-025-06131-z","article-title":"Health-related quality of life in Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome and Post COVID-19 Condition: A systematic review","volume":"23","author":"B Weigel","year":"2025","journal-title":"J Transl Med"},{"issue":"1","key":"pone.0338433.ref049","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.colegn.2017.02.005","article-title":"Patient-centred care as an approach to improving health care in Australia","volume":"25","author":"L Jo Delaney","year":"2018","journal-title":"Collegian"},{"issue":"1","key":"pone.0338433.ref050","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0261808","article-title":"Consumer engagement in health care policy, research and services: A systematic review and meta-analysis of methods and effects","volume":"17","author":"LK Wiles","year":"2022","journal-title":"PLoS 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