{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T18:33:46Z","timestamp":1765478026235,"version":"3.48.0"},"reference-count":30,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T00:00:00Z","timestamp":1765411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:p>The aim of the study was to compare the effects of 52\u2009mg Levonorgestrel-releasing intrauterine device (LNG-IUD), which is frequently used in patients with heavy menstrual bleeding, on quality of life according to benign endometrial pathology patterns. The study was designed retrospectively.143 patients between the ages of 28 and 54, who underwent endometrial sampling due to heavy menstrual bleeding and then the 52\u2009mg LNG-IUD was placed, were included in the study. The most commonly observed results in endometrial pathology were divided into 2 groups: normal cycle patterns and hormonal imbalance patterns. Change in quality of life after LNG-IUD insertion was assessed using the Menorrhagia Multiattribute Scale (MMAS), the 36-Item Short Form Health Survey (SF-36), and the Beck Depression Inventory. In both groups, a significant increase was observed in all parameters of the SF-36 quality of life scale and the MMAS total score after LNG-IUD use compared to the pre-IUD period (p\u2009&lt;\u20090.05) (MMAS increased from 51.9\u2009\u00b1\u200927.8% to 83.8\u2009\u00b1\u200926.2% at 6 months), and a significant decrease was observed in the Beck Depression Inventory score and depression rate (p\u2009&lt;\u20090.05). However, there was no significant difference in the changes in quality of life questionnaires before and after LNG-IUD use between the groups (p\u2009&gt;\u20090.05). The LNG-IUD provides substantial improvements in bleeding control and quality of life among women with heavy menstrual bleeding, and these effects are not influenced by endometrial pathology results.<\/jats:p>","DOI":"10.1371\/journal.pone.0338480","type":"journal-article","created":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T18:30:32Z","timestamp":1765477832000},"page":"e0338480","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Levonorgestrel-releasing intrauterine device treatment in heavy menstrual bleeding: Correlation with endometrial pathology and quality of life"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6849-0136","authenticated-orcid":true,"given":"Selma Atiye","family":"Kolcu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ebru","family":"Kara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elif","family":"Y\u0131ld\u0131z","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arzu","family":"\u00c7etin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2025,12,11]]},"reference":[{"issue":"1","key":"pone.0338480.ref001","first-page":"483","article-title":"Heavy menstrual bleeding-visual analog scale, an easy-to-use tool for excessive menstrual blood loss that interferes with quality-of-life screening in clinical practice","volume":"3","author":"J Perell\u00f3","year":"2022","journal-title":"Womens Health Rep (New Rochelle)"},{"issue":"3","key":"pone.0338480.ref002","article-title":"Comparison of bleeding pattern and quality of life before and after the insertion of a levonorgestrel intrauterine system for heavy menstrual bleeding: a seven-year review","volume":"15","author":"M Agarwal","year":"2023","journal-title":"Cureus"},{"key":"pone.0338480.ref003","article-title":"London: National Institute for Health and Care Excellence (NICE","journal-title":"NICE Guideline"},{"key":"pone.0338480.ref004","unstructured":"2021 exceptional surveillance of heavy menstrual bleeding: assessment and management (NICE guideline NG88) [Internet]. London: National Institute for Health and Care Excellence (NICE); 2021 May 24. (access: 01.07.2025). 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