{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T21:12:12Z","timestamp":1765228332110,"version":"3.46.0"},"reference-count":57,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T00:00:00Z","timestamp":1765152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the National Traditional Chinese Medicine Expert Inheritance Studio Construction Project","award":["Document No. [2022] 75 from the National Administration of Traditional Chinese Medicine"],"award-info":[{"award-number":["Document No. [2022] 75 from the National Administration of Traditional Chinese Medicine"]}]},{"name":"the Scientific Research Plan Project of the Health Commission of Hunan Province","award":["Grant No. C202303078160"],"award-info":[{"award-number":["Grant No. C202303078160"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sepsis and atrial fibrillation are complex, life-threatening medical conditions affecting approximately 49 million individuals globally, characterized by exceptionally high mortality rates. Lipid metabolism abnormalities play a critical role in the pathogenesis of these diseases, yet their underlying molecular mechanisms remain incompletely understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This innovative study systematically investigates the shared molecular mechanisms of lipid metabolism abnormalities in sepsis and atrial fibrillation using advanced bioinformatics and machine learning methodologies. Methods: We retrieved two independent research cohorts from the Gene Expression Omnibus database: sepsis-related datasets and atrial fibrillation-related datasets. A multi-dimensional analytical approach was employed, including differential expression analysis, Weighted Gene Co-expression Network Analysis, machine learning models, immune cell infiltration analysis, and gene set enrichment analysis to comprehensively elucidate the molecular mechanisms of lipid metabolism abnormalities in these diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Comprehensive analysis identified 13 key candidate genes, with CD81, CKAP4, and DPEP2 emerging as core characteristic genes. Functional enrichment analysis revealed these genes primarily participate in mitochondrial function regulation, complement-coagulation cascade, and cell adhesion molecular pathways. Machine learning models demonstrated exceptional diagnostic performance, with area under the curve values of 0.957 for sepsis and 1.000 for atrial fibrillation datasets. Immune cell infiltration analysis unveiled the critical roles of neutrophils and monocytes in disease progression, and revealed the profound impact of lipid metabolism abnormalities on immune regulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We discovered that lipid metabolism abnormalities significantly modulate disease progression by influencing mitochondrial function, inflammatory responses, and cell adhesion pathways. Future research necessitates further clinical validation and functional experiments to explore personalized therapeutic strategies based on lipid reprogramming.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0338511","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T18:30:50Z","timestamp":1765218650000},"page":"e0338511","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Molecular mechanisms of lipid metabolism abnormalities driving sepsis and atrial fibrillation: A Systematic study based on bioinformatics and machine learning"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-2347-1614","authenticated-orcid":true,"given":"Changze","family":"Ou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haidong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Binbin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7489-3943","authenticated-orcid":true,"given":"Huajun","family":"Long","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2025,12,8]]},"reference":[{"issue":"8","key":"pone.0338511.ref001","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The third international consensus definitions for sepsis and septic shock (Sepsis-3)","volume":"315","author":"M Singer","year":"2016","journal-title":"JAMA"},{"issue":"2","key":"pone.0338511.ref002","doi-asserted-by":"crossref","first-page":"146","DOI":"10.7861\/clinmedicine.18-2-146","article-title":"Diagnosis and management of sepsis","volume":"18","author":"T Evans","year":"2018","journal-title":"Clin Med (Lond)"},{"issue":"10219","key":"pone.0338511.ref003","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S0140-6736(19)32989-7","article-title":"Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the Global Burden of Disease Study","volume":"395","author":"KE Rudd","year":"2020","journal-title":"Lancet"},{"issue":"1","key":"pone.0338511.ref004","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1186\/s12879-022-07543-8","article-title":"Frequency and mortality of sepsis and septic shock in China: a systematic review and meta-analysis","volume":"22","author":"Y-C Liu","year":"2022","journal-title":"BMC Infect Dis"},{"key":"pone.0338511.ref005","doi-asserted-by":"crossref","first-page":"628302","DOI":"10.3389\/fmed.2021.628302","article-title":"Sepsis-pathophysiology and therapeutic concepts","volume":"8","author":"D Jarczak","year":"2021","journal-title":"Front Med (Lausanne)"},{"issue":"11","key":"pone.0338511.ref006","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.117.007559","article-title":"Symptom burden of atrial fibrillation and its relation to interventions and outcome in Europe","volume":"7","author":"RB Schnabel","year":"2018","journal-title":"J Am Heart Assoc"},{"key":"pone.0338511.ref007","doi-asserted-by":"crossref","first-page":"100785","DOI":"10.1016\/j.lanepe.2023.100785","article-title":"Atrial fibrillation: pathophysiology, genetic and epigenetic mechanisms","volume":"37","author":"M Vinciguerra","year":"2024","journal-title":"Lancet Reg Health Eur"},{"issue":"16","key":"pone.0338511.ref008","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1016\/j.jacc.2017.02.043","article-title":"Improving atrial fibrillation therapy: is there a gene for that?","volume":"69","author":"WJ Hucker","year":"2017","journal-title":"J Am Coll Cardiol"},{"issue":"9","key":"pone.0338511.ref009","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1097\/CCM.0000000000005883","article-title":"Atrial fibrillation (AFIB) in the ICU: incidence, risk factors, and outcomes: the international AFIB-ICU cohort study","volume":"51","author":"M Wetterslev","year":"2023","journal-title":"Crit Care Med"},{"issue":"4","key":"pone.0338511.ref010","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1378\/chest.15-0358","article-title":"Optimizing atrial fibrillation management: from ICU and beyond","volume":"148","author":"AJ Walkey","year":"2015","journal-title":"Chest"},{"key":"pone.0338511.ref011","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ajem.2020.12.062","article-title":"Outcomes of new-onset atrial fibrillation in patients with sepsis: a systematic review and meta-analysis of 225,841 patients","volume":"42","author":"F-P Xiao","year":"2021","journal-title":"Am J Emerg Med"},{"issue":"6","key":"pone.0338511.ref012","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1016\/j.chest.2018.03.040","article-title":"Atrial fibrillation in the ICU","volume":"154","author":"NA Bosch","year":"2018","journal-title":"Chest"},{"key":"pone.0338511.ref013","doi-asserted-by":"crossref","first-page":"1224335","DOI":"10.3389\/fimmu.2023.1224335","article-title":"Lipid oxidation dysregulation: an emerging player in the pathophysiology of sepsis","volume":"14","author":"R Muniz-Santos","year":"2023","journal-title":"Front Immunol"},{"issue":"2","key":"pone.0338511.ref014","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.201911319","article-title":"Hepatic PPAR\u03b1 function and lipid metabolic pathways are dysregulated in polymicrobial sepsis","volume":"12","author":"L Van Wyngene","year":"2020","journal-title":"EMBO Mol Med"},{"issue":"2","key":"pone.0338511.ref015","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1097\/MOL.0000000000000870","article-title":"Circulating protein and lipid markers of early sepsis diagnosis and prognosis: a scoping review","volume":"34","author":"G Barber","year":"2023","journal-title":"Curr Opin Lipidol"},{"issue":"8","key":"pone.0338511.ref016","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1004044","article-title":"Lipid levels in midlife and risk of atrial fibrillation over 3 decades-experience from the Swedish AMORIS cohort: a cohort study","volume":"19","author":"M Ding","year":"2022","journal-title":"PLoS Med"},{"issue":"1","key":"pone.0338511.ref017","doi-asserted-by":"crossref","first-page":"134","DOI":"10.3390\/ijms17010134","article-title":"VLDL from metabolic syndrome individuals enhanced lipid accumulation in atria with association of susceptibility to atrial fibrillation","volume":"17","author":"H-C Lee","year":"2016","journal-title":"Int J Mol Sci"},{"issue":"1","key":"pone.0338511.ref018","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1186\/s12933-024-02545-z","article-title":"ANXA1-FPR2 axis mitigates the susceptibility to atrial fibrillation in obesity via rescuing AMPK activity in response to lipid overload","volume":"23","author":"P Liu","year":"2024","journal-title":"Cardiovasc Diabetol"},{"issue":"8","key":"pone.0338511.ref019","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1136\/heartjnl-2022-321633","article-title":"Dysregulated carbohydrate and lipid metabolism and risk of atrial fibrillation in advanced old age","volume":"109","author":"CN Pellegrini","year":"2023","journal-title":"Heart"},{"issue":"10","key":"pone.0338511.ref020","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1038\/s41569-024-01038-6","article-title":"Metabolic remodelling in atrial fibrillation: manifestations, mechanisms and clinical implications","volume":"21","author":"D Bode","year":"2024","journal-title":"Nat Rev Cardiol"},{"issue":"3","key":"pone.0338511.ref021","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.mito.2011.01.010","article-title":"The multiple functions of cytochrome c and their regulation in life and death decisions of the mammalian cell: From respiration to apoptosis","volume":"11","author":"M H\u00fcttemann","year":"2011","journal-title":"Mitochondrion"},{"issue":"4","key":"pone.0338511.ref022","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s00109-019-01756-2","article-title":"Mitochondrial quality control mechanisms as potential therapeutic targets in sepsis-induced multiple organ failure","volume":"97","author":"Y Wu","year":"2019","journal-title":"J Mol Med (Berl)"},{"issue":"14","key":"pone.0338511.ref023","doi-asserted-by":"crossref","first-page":"8144","DOI":"10.1073\/pnas.96.14.8144","article-title":"Apoptosis in heart failure: release of cytochrome c from mitochondria and activation of caspase-3 in human cardiomyopathy","volume":"96","author":"J Narula","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"17","key":"pone.0338511.ref024","doi-asserted-by":"crossref","first-page":"8152","DOI":"10.7150\/thno.55334","article-title":"Fructose-coated \u00c5ngstrom silver prevents sepsis by killing bacteria and attenuating bacterial toxin-induced injuries","volume":"11","author":"H Yin","year":"2021","journal-title":"Theranostics"},{"issue":"1","key":"pone.0338511.ref025","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/s12933-019-0928-8","article-title":"Atrial fibrillation and its arrhythmogenesis associated with insulin resistance","volume":"18","author":"Y-H Chan","year":"2019","journal-title":"Cardiovasc Diabetol"},{"issue":"10","key":"pone.0338511.ref026","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1038\/s42255-020-0261-2","article-title":"Fructose stimulated de novo lipogenesis is promoted by inflammation","volume":"2","author":"J Todoric","year":"2020","journal-title":"Nat Metab"},{"issue":"9","key":"pone.0338511.ref027","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1086\/379044","article-title":"Association of mannose-binding lectin polymorphisms with sepsis and fatal outcome, in patients with systemic inflammatory response syndrome","volume":"188","author":"P Garred","year":"2003","journal-title":"J Infect Dis"},{"issue":"4","key":"pone.0338511.ref028","first-page":"1524","article-title":"Biomarkers of diabetes: role in the pathogenesis of atrial fibrillation","volume":"28","author":"S Rafaqat","year":"2024","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"21","key":"pone.0338511.ref029","doi-asserted-by":"crossref","first-page":"12965","DOI":"10.3390\/ijms232112965","article-title":"Impact of High-Density Lipoproteins on Sepsis","volume":"23","author":"B De Geest","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"5","key":"pone.0338511.ref030","doi-asserted-by":"crossref","first-page":"167761","DOI":"10.1016\/j.bbadis.2025.167761","article-title":"Sepsis and high-density lipoproteins: pathophysiology and potential new therapeutic targets","volume":"1871","author":"C Parolini","year":"2025","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"issue":"1","key":"pone.0338511.ref031","doi-asserted-by":"crossref","first-page":"3547","DOI":"10.1038\/s41598-021-82998-4","article-title":"The association between impairment of HDL cholesterol efflux capacity and atrial remodeling in atrial fibrillation","volume":"11","author":"A Minami-Takano","year":"2021","journal-title":"Sci Rep"},{"issue":"3","key":"pone.0338511.ref032","doi-asserted-by":"crossref","first-page":"222","DOI":"10.2174\/1570161116666180817155058","article-title":"The pleiotropic effects of statins - from coronary artery disease and stroke to atrial fibrillation and ventricular tachyarrhythmia","volume":"17","author":"A Oesterle","year":"2019","journal-title":"Curr Vasc Pharmacol"},{"issue":"3","key":"pone.0338511.ref033","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20200551","article-title":"Elongated neutrophil-derived structures are blood-borne microparticles formed by rolling neutrophils during sepsis","volume":"218","author":"A Marki","year":"2021","journal-title":"J Exp Med"},{"key":"pone.0338511.ref034","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.thromres.2018.11.026","article-title":"Elevated blood plasma levels of tissue factor-bearing extracellular vesicles in patients with atrial fibrillation","volume":"173","author":"M M\u00f8rk","year":"2019","journal-title":"Thromb Res"},{"issue":"23","key":"pone.0338511.ref035","article-title":"Lipolysis-derived linoleic acid drives beige fat progenitor cell proliferation","volume":"57","author":"I Abe","year":"2022","journal-title":"Dev Cell"},{"issue":"2","key":"pone.0338511.ref036","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1080\/1354750X.2024.2319296","article-title":"Investigation of exosomal tetraspanin profile in sepsis patients as a promising diagnostic biomarker","volume":"29","author":"R Bhagwan Valjee","year":"2024","journal-title":"Biomarkers"},{"issue":"8","key":"pone.0338511.ref037","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1161\/CIRCRESAHA.116.305012","article-title":"Vascular smooth muscle cell calcification is mediated by regulated exosome secretion","volume":"116","author":"AN Kapustin","year":"2015","journal-title":"Circ Res"},{"issue":"4","key":"pone.0338511.ref038","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1080\/15548627.2024.2435236","article-title":"CKAP4 in hepatocellular carcinoma: competitive RETREG1\/FAM134B binding, reticulophagy regulation, and cancer progression","volume":"21","author":"J Mo","year":"2025","journal-title":"Autophagy"},{"issue":"2","key":"pone.0338511.ref039","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1161\/CIRCULATIONAHA.117.030742","article-title":"Single-cell sequencing of the healthy and diseased heart reveals cytoskeleton-associated protein 4 as a new modulator of fibroblasts activation","volume":"138","author":"MM Gladka","year":"2018","journal-title":"Circulation"},{"issue":"1","key":"pone.0338511.ref040","doi-asserted-by":"crossref","first-page":"17136","DOI":"10.1038\/s41598-021-96618-8","article-title":"Right versus left ventricular remodeling in heart failure due to chronic volume overload","volume":"11","author":"T Havlenova","year":"2021","journal-title":"Sci Rep"},{"issue":"1","key":"pone.0338511.ref041","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/s41392-022-01183-9","article-title":"SARS-CoV-2 Spike protein promotes vWF secretion and thrombosis via endothelial cytoskeleton-associated protein 4 (CKAP4)","volume":"7","author":"K Li","year":"2022","journal-title":"Signal Transduct Target Ther"},{"issue":"6","key":"pone.0338511.ref042","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1111\/all.13726","article-title":"Dysregulated fatty acid metabolism in nasal polyp-derived eosinophils from patients with chronic rhinosinusitis","volume":"74","author":"J Miyata","year":"2019","journal-title":"Allergy"},{"issue":"7","key":"pone.0338511.ref043","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1038\/s41418-025-01468-w","article-title":"The Trim32-DPEP2 axis is an inflammatory switch in macrophages during intestinal inflammation","volume":"32","author":"Z Zhan","year":"2025","journal-title":"Cell Death Differ"},{"key":"pone.0338511.ref044","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3389\/fcimb.2019.00057","article-title":"Dpep2 emerging as a modulator of macrophage inflammation confers protection against CVB3-induced viral myocarditis","volume":"9","author":"X Yang","year":"2019","journal-title":"Front Cell Infect Microbiol"},{"issue":"17","key":"pone.0338511.ref045","doi-asserted-by":"crossref","first-page":"5502","DOI":"10.3390\/molecules27175502","article-title":"Exosome proteomics reveals the deregulation of coagulation, complement and lipid metabolism proteins in gestational diabetes mellitus","volume":"27","author":"EG Bernea","year":"2022","journal-title":"Molecules"},{"key":"pone.0338511.ref046","article-title":"Crosstalk between the coagulation and complement systems in sepsis","author":"F Lupu","year":"2014","journal-title":"Thromb Res"},{"issue":"11","key":"pone.0338511.ref047","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0198461","article-title":"Circulating proteomic patterns in AF related left atrial remodeling indicate involvement of coagulation and complement cascade","volume":"13","author":"J Kornej","year":"2018","journal-title":"PLoS One"},{"key":"pone.0338511.ref048","doi-asserted-by":"crossref","first-page":"112550","DOI":"10.1016\/j.intimp.2024.112550","article-title":"Neutrophil extracellular traps and neutrophil extracellular traps-related genes are involved in new-onset atrial fibrillation in LPS-induced sepsis","volume":"138","author":"J Xiang","year":"2024","journal-title":"Int Immunopharmacol"},{"issue":"1","key":"pone.0338511.ref049","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s12929-023-00957-9","article-title":"Exosomal PGE2 from M2 macrophages inhibits neutrophil recruitment and NET formation through lipid mediator class switching in sepsis","volume":"30","author":"Y Jiao","year":"2023","journal-title":"J Biomed Sci"},{"issue":"1","key":"pone.0338511.ref050","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1186\/s12872-023-03270-3","article-title":"Associations between neutrophil-lymphocyte ratio and monocyte to high-density lipoprotein ratio with left atrial spontaneous echo contrast or thrombus in patients with non-valvular atrial fibrillation","volume":"23","author":"Y Deng","year":"2023","journal-title":"BMC Cardiovasc Disord"},{"issue":"1","key":"pone.0338511.ref051","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/s41392-023-01497-2","article-title":"Interaction between neutrophil extracellular traps and cardiomyocytes contributes to atrial fibrillation progression","volume":"8","author":"L He","year":"2023","journal-title":"Signal Transduct Target Ther"},{"issue":"8","key":"pone.0338511.ref052","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1093\/europace\/euw195","article-title":"Monocyte-to-HDL-cholesterol ratio and left atrial remodelling in atrial fibrillation","volume":"19","author":"U Canpolat","year":"2017","journal-title":"Europace"},{"issue":"22","key":"pone.0338511.ref053","doi-asserted-by":"crossref","first-page":"16244","DOI":"10.3390\/ijms242216244","article-title":"Influence of microbiota-related metabolites associated with inflammation and sepsis on the peroxidase activity of cyclooxygenase in healthy human monocytes and acute monocytic leukemia cells","volume":"24","author":"N Beloborodova","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"1","key":"pone.0338511.ref054","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1186\/s13019-024-03136-5","article-title":"The predictive value of monocyte count to high-density lipoprotein cholesterol ratio combined with left atrial diameter for post-radiofrequency ablation recurrence of paroxysmal atrial fibrillation in patients","volume":"19","author":"Y Lei","year":"2024","journal-title":"J Cardiothorac Surg"},{"issue":"12","key":"pone.0338511.ref055","doi-asserted-by":"crossref","first-page":"9892","DOI":"10.3168\/jds.2023-23602","article-title":"Subclinical ketosis leads to lipid metabolism disorder by downregulating the expression of acetyl-coenzyme A acetyltransferase 2 in dairy cows","volume":"106","author":"S Zhou","year":"2023","journal-title":"J Dairy Sci"},{"issue":"1","key":"pone.0338511.ref056","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1097\/shk.0b013e31802ec5d2","article-title":"Role of retinoid-X receptor-alpha in the suppression of rat bile acid coenzyme A-amino acid N-acyltransferase in liver during sepsis","volume":"28","author":"Y-H Chen","year":"2007","journal-title":"Shock"},{"issue":"8","key":"pone.0338511.ref057","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1089\/ars.2013.5542","article-title":"Targeting inflammation and oxidative stress in atrial fibrillation: role of 3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibition with statins","volume":"20","author":"AC Pinho-Gomes","year":"2014","journal-title":"Antioxid Redox Signal"}],"container-title":["PLOS One"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0338511","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T18:30:59Z","timestamp":1765218659000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0338511"}},"subtitle":[],"editor":[{"given":"Wenxing","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2025,12,8]]},"references-count":57,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2025,12,8]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0338511","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,8]]}}}