{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T23:50:07Z","timestamp":1784245807728,"version":"3.55.0"},"reference-count":68,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T00:00:00Z","timestamp":1764806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010724","name":"Health Systems Research Institute","doi-asserted-by":"publisher","award":["MET6605004S"],"award-info":[{"award-number":["MET6605004S"]}],"id":[{"id":"10.13039\/501100010724","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Science Research and Innovation Fund (NSRF) and Prince of Songkla University","award":["MET6601207S"],"award-info":[{"award-number":["MET6601207S"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:p>\n                    Ternary complex of curcuminoid-rich extract (CRE-Ter) is a developed water-soluble\n                    <jats:italic>Curcuma longa<\/jats:italic>\n                    extract containing 14%\n                    <jats:italic>w\/w<\/jats:italic>\n                    curcuminoids, hydroxypropyl-\u03b2-cyclodextrin, and polyvinylpyrrolidone K30. This study aimed to investigate the biomolecular effects of CRE-Ter on differentiation of bone cells (murine MC3T3-E1 preosteoblasts), muscle cells (murine dexamethasone-treated C2C12 myotubes) atrophy and irisin expression. In MC3T3-E1 preosteoblasts, CRE-Ter treatment increased alkaline phosphatase activity, calcium deposition, and expression of Bmp-2, Runx2, and collagen 1a significantly and dose-dependently. 5, 10, and 20 \u00b5g\/mL CRE-Ter upregulated \u03b2-catenin expression significantly. CRE-Ter improved the atrophy of dexamethasone-treated C2C12 myotubes. CRE-Ter decreased proinflammatory cytokine (TNF-\u03b1 and IL-6) expression but increased FNDC5 and irisin expression and nitric oxide production in dexamethasone-treated C2C12 myotubes significantly and dose-dependently. Dexamethasone promoted \u03b2-catenin and total p38 expression in C2C12 myotubes. CRE-Ter at 2.5\u201320 \u00b5g\/mL reversed the increase in \u03b2-catenin expression, whereas 2.5 \u00b5g\/mL reversed total p38 expression. Crosstalk experiments further revealed that conditioned medium from C2C12 myotubes enhanced osteocalcin expression in MC3T3-E1 osteoblasts. Molecular docking simulations using CB-Dock2 showed strong interactions between each curcuminoid molecule and irisin. Therefore, CRE-Ter may stimulate osteoblast differentiation, ameliorate myotube atrophy, and increase irisin expression, indicating its therapeutic potential in osteoporosis, sarcopenia, and osteosarcopenia.\n                  <\/jats:p>","DOI":"10.1371\/journal.pone.0338571","type":"journal-article","created":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T18:55:46Z","timestamp":1764874546000},"page":"e0338571","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["CRE-Ter enhances murine bone differentiation, improves muscle cell atrophy, and increases irisin expression"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-9730-3620","authenticated-orcid":true,"given":"Sompot","family":"Jantarawong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7899-0118","authenticated-orcid":true,"given":"Wipapan","family":"Khimmaktong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pharkphoom","family":"Panichayupakaranant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9329-4084","authenticated-orcid":true,"given":"Yutthana","family":"Pengjam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2025,12,4]]},"reference":[{"key":"pone.0338571.ref001","doi-asserted-by":"crossref","first-page":"116570","DOI":"10.1016\/j.bone.2022.116570","article-title":"Osteoporosis 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