{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T19:12:18Z","timestamp":1772219538269,"version":"3.50.1"},"reference-count":44,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fonds de Recherche du Qu\u00e9bec \u2013 Sant\u00e9 (FRQS)\/Oncopole","award":["2023\u20132025, DO: 10.69777\/321941"],"award-info":[{"award-number":["2023\u20132025, DO: 10.69777\/321941"]}]},{"name":"Fonds de Recherche du Qu\u00e9bec \u2013 Sant\u00e9","award":["2024\u20132025, Award BF15\u2013341746"],"award-info":[{"award-number":["2024\u20132025, Award BF15\u2013341746"]}]},{"name":"Fonds de Recherche du Qu\u00e9bec \u2013 Sant\u00e9","award":["2024\u20132027, DO: 10.69777\/329980"],"award-info":[{"award-number":["2024\u20132027, DO: 10.69777\/329980"]}]},{"DOI":"10.13039\/100018359","name":"Fondation de l\u2019H\u00f4pital Maisonneuve-Rosemont","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100018359","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Stem cell transplantation is a highly stressful treatment for hematological cancer patients, negatively impacting their quality of life. Hypnosis has proven effective in managing symptoms like pain, fatigue, and anxiety, and improving quality of life. Virtual reality (VR) is used in cancer treatments to distract from pain, and combining VR with hypnosis (VRH) could enhance the hypnotic experience. However, methodological limitations in current studies prevent clear evaluation of its effectiveness, particularly for individualized care and psychosocial interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>1) To evaluate the preliminary effects of VRH in reducing anxiety, pain, and fatigue during stem cell transplant, improving quality of life post-intervention. 2) To assess intervention feasibility, including patients\u2019 experiences, satisfaction levels, and recommendations for improving the VRH tool.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study will involve 60 hematology patients divided into two groups: VRH and waiting list. Anxiodepressive symptoms, pain, quality of life, fatigue, absorption, dissociation, and amusement will be assessed before, immediately after the intervention, and at one- and three-month follow-ups using validated psychological scales and numeric rating scales (0\u201310). Semi-structured interviews will capture patient expectations, satisfaction, and feedback. Data will be analyzed using MANOVA (or non-parametric alternatives) and thematic analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>The study\u2019s primary goal is to assess VRH\u2019s effectiveness compared to standard care in a feasibility randomized controlled trial (RCT). It will also provide data for improving the VRH tool (version 2.0) and assess its usability. In the long term, findings will help integrate VRH into oncology clinics, offering an innovative intervention to support patients throughout treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec005\">\n                    <jats:title>ClinicalTrial registration<\/jats:title>\n                    <jats:p>\n                      ClinicalTrials.gov\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT06817759\" xlink:type=\"simple\">NCT06817759<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0338617","type":"journal-article","created":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T18:30:48Z","timestamp":1772217048000},"page":"e0338617","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Using virtual reality hypnosis during stem cell transplant for patients in hematology: A protocol for a feasibility randomized study"],"prefix":"10.1371","volume":"21","author":[{"given":"Audrey","family":"Laurin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1998-5471","authenticated-orcid":true,"given":"Floriane","family":"Rousseaux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1289-8968","authenticated-orcid":true,"given":"Valentyn","family":"Fournier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean","family":"Roy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathieu","family":"Landry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"LeBlanc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia","family":"Godin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Arbour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Richeb\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karim","family":"Jerbi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Rainville","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Ogez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2026,2,27]]},"reference":[{"issue":"4","key":"pone.0338617.ref001","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1007\/s11764-020-00869-9","article-title":"Quality of life in \u201cchronic\u201d cancer survivors: a meta-analysis","volume":"14","author":"J Firkins","year":"2020","journal-title":"J Cancer Surviv"},{"issue":"19","key":"pone.0338617.ref002","doi-asserted-by":"crossref","first-page":"6938","DOI":"10.3390\/ijerph17196938","article-title":"Quality of Life of Cancer Patients Treated with Chemotherapy","volume":"17","author":"A Lewandowska","year":"2020","journal-title":"Int J Environ Res Public Health"},{"issue":"4","key":"pone.0338617.ref003","doi-asserted-by":"crossref","DOI":"10.1038\/bcj.2015.29","article-title":"Haematological cancer and quality of life: a systematic literature review","volume":"5","author":"P Allart-Vorelli","year":"2015","journal-title":"Blood Cancer J"},{"issue":"4","key":"pone.0338617.ref004","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1002\/pon.5321","article-title":"Distress in cancer patients: Who are the main groups at risk?","volume":"29","author":"P Herschbach","year":"2020","journal-title":"Psychooncology"},{"key":"pone.0338617.ref005","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/978-981-19-5802-1_20","article-title":"Indications for Autologous Stem Cell Transplant.","author":"SK. 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