{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T18:56:29Z","timestamp":1766084189551,"version":"3.48.0"},"reference-count":44,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"PAPIIT UNAM","award":["IN214524"],"award-info":[{"award-number":["IN214524"]}]},{"name":"CONCYTEQ\/CACTI","award":["094\/2024."],"award-info":[{"award-number":["094\/2024."]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:p>Limb amputation triggers a reorganization of brain structure and function. Previous research using neuroimaging techniques, such as resting state functional magnetic resonance imaging, indicates reduced functional connectivity in the sensorimotor network in amputees compared to non-amputees. Yet, data on lower limb amputees remains limited. We investigated functional connectivity differences within the sensorimotor network (S1M1) using an analysis of 10 regions of interest in a group of 26 lower limb amputees compared to non-amputees. The statistical analysis revealed a decreased connectivity network component involving cerebellar regions within the S1M1 network, specifically between the contralateral Cerebellum and primary sensorimotor cortical areas ipsilateral to the amputated limb. These findings underscore the complexity of cerebral adaptations post-amputation, highlighting a significant decrease in functional connectivity at network level. The research emphasizes the importance of investigating changes in functional connectivity in this population to understand the neuroadaptive processes resulting from an amputation.<\/jats:p>","DOI":"10.1371\/journal.pone.0338619","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T18:39:47Z","timestamp":1766083187000},"page":"e0338619","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cerebellar functional connectivity alteration in individuals with lower limb amputation"],"prefix":"10.1371","volume":"20","author":[{"given":"Daniel","family":"Arregu\u00edn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Trejo-M\u00e9ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon","family":"Pedroza-Ram\u00edrez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0637-0833","authenticated-orcid":true,"given":"Erick","family":"Pasaye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1913-1603","authenticated-orcid":true,"given":"Livia","family":"S\u00e1nchez-Carrasco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"V\u00e1zquez-Vela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3032-3527","authenticated-orcid":true,"given":"Ra\u00fal G.","family":"Paredes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2025,12,18]]},"reference":[{"key":"pone.0338619.ref001","doi-asserted-by":"crossref","first-page":"44780","DOI":"10.1038\/srep44780","article-title":"Altered microstructure rather than morphology in the corpus callosum after lower limb amputation","volume":"7","author":"Z Li","year":"2017","journal-title":"Sci Rep"},{"key":"pone.0338619.ref002","doi-asserted-by":"crossref","first-page":"823185","DOI":"10.1155\/2015\/823185","article-title":"The Plasticity of Brain Gray Matter and White Matter following Lower Limb Amputation","volume":"2015","author":"G Jiang","year":"2015","journal-title":"Neural Plast"},{"key":"pone.0338619.ref003","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3389\/fnhum.2016.00079","article-title":"Progressive Thinning of Visual Motion Area in Lower Limb Amputees","volume":"10","author":"G Jiang","year":"2016","journal-title":"Front Hum Neurosci"},{"issue":"1","key":"pone.0338619.ref004","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1038\/s41598-017-18772-2","article-title":"Cerebellar grey matter modifications in lower limb amputees not using prosthesis","volume":"8","author":"A Di Vita","year":"2018","journal-title":"Sci Rep"},{"key":"pone.0338619.ref005","doi-asserted-by":"crossref","first-page":"311","DOI":"10.3389\/fnhum.2013.00311","article-title":"Plasticity in the Visual System is Associated with Prosthesis Use in Phantom Limb Pain","volume":"7","author":"S Prei\u00dfler","year":"2013","journal-title":"Front Hum Neurosci"},{"issue":"6","key":"pone.0338619.ref006","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1177\/197140091002300604","article-title":"Event-Related Functional Magnetic Resonance Images during the Perception of Phantom Limb. 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