{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T13:18:31Z","timestamp":1771852711241,"version":"3.50.1"},"reference-count":40,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"TAEJOON Pharmaceutical Co., Ltd"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to compare abdominopelvic computed tomography (APCT) image quality using low and high concentrations of a contrast agent in patients with cancer via a noninferiority design.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study prospectively included 99 patients with malignancies who underwent dual-source APCT following injection of 1.5 mL\/kg of iohexol 270 (low-concentration group). The control group included patients who were retrospectively matched 1:1 based on weight, body mass index, and sex. These patients (high-concentration group) received 1.1 or 1.2 mL\/kg of iohexol 350, reconstructed at two tube voltages (80 kVp and 80\/Sn150 kVp). The noninferiority margins were set at \u22120.21 for overall image quality. Two radiologists blindly and independently analyzed the subjective and objective image quality of matching focal lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 198 patients with 102 focal lesions (44 liver lesions, 58 renal lesions) were assessed. The total iodine amount was slightly higher in the low-concentration group than in the high-concentration group without significant differences (24580.0\u2009\u00b1\u20093745.6 vs. 24190.2\u2009\u00b1\u20093954.3 mg I\/mL;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.051). Overall image quality did not differ significantly between the groups (2.6\u2009\u00b1\u20090.5 vs. 2.6\u2009\u00b1\u20090.5 on 80 kVp;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.484; 3.4\u2009\u00b1\u20090.5 vs. 3.4\u2009\u00b1\u20090.6 on 80\/Sn 150 kVp,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.891). Margin sharpness and conspicuity also showed no significant differences between the low- and high-concentration groups at 80 kVp (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.890, 0.103) and 80\/Sn 150 kVp images (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.278, 0.369). Liver attenuation was slightly higher in the low-concentration than in the high-concentration group (80 kVp, 127.3\u2009\u00b1\u200916.8 vs. 122.4\u2009\u00b1\u200913.0,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.013; 80 kVp\/Sn 150 kVp, 108.2\u2009\u00b1\u200913.3 vs. 104.5\u2009\u00b1\u200910.9,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.025). No major or minor adverse reactions occurred during or immediately after contrast agent injection in either group. Five patients in the low-concentration group experienced below-average vascular pain.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The low-concentration group offered noninferior overall image quality compared to the high-concentration group among patients with cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0338726","type":"journal-article","created":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T18:45:05Z","timestamp":1767638705000},"page":"e0338726","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Low-concentration contrast abdominopelvic CT: A comparison with high-concentration contrast CT image quality"],"prefix":"10.1371","volume":"21","author":[{"given":"Sungjin","family":"Yoon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3631-6029","authenticated-orcid":true,"given":"Joo-Hwan","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sun Jin","family":"Sym","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Hyuk","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Sung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9935-2863","authenticated-orcid":true,"given":"So Hyun","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2026,1,5]]},"reference":[{"issue":"6","key":"pone.0338726.ref001","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1007\/s40620-018-0498-y","article-title":"Contrast medium induced acute kidney injury: a narrative review","volume":"31","author":"V Pistolesi","year":"2018","journal-title":"J Nephrol"},{"issue":"7","key":"pone.0338726.ref002","doi-asserted-by":"crossref","first-page":"2845","DOI":"10.1007\/s00330-017-5246-5","article-title":"Post-contrast acute kidney injury - Part 1: Definition, clinical features, incidence, role of contrast medium and risk factors\u00a0: recommendations for updated ESUR contrast medium safety committee guidelines","volume":"28","author":"AJ van der Molen","year":"2018","journal-title":"Eur Radiol"},{"issue":"7","key":"pone.0338726.ref003","doi-asserted-by":"crossref","first-page":"2856","DOI":"10.1007\/s00330-017-5247-4","article-title":"Post-contrast acute kidney injury. 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