{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T19:30:48Z","timestamp":1776713448832,"version":"3.51.2"},"reference-count":93,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:p>\n                    Parkinson\u2019s disease (PD) presents as a progressive deterioration of dopaminergic neurons, a process closely associated with increased oxidative damage due to accumulated reactive oxygen species, leading to weakened antioxidant defenses and ultimately neuronal dysfunction. Currently, no definitive approach exists to counteract the degeneration of dopaminergic neurons in PD. The use of\n                    <jats:italic>Tamarix aphylla<\/jats:italic>\n                    as a protective agent against Parkinson\u2019s disease is not well studied yet. In this study, a rotenone-induced rodent model was utilized to examine the neuroprotective potential of\n                    <jats:italic>T. aphylla<\/jats:italic>\n                    extract. The chemical composition of\n                    <jats:italic>T. aphylla<\/jats:italic>\n                    leaves was analyzed through LC-HR-ESI-MS profiling, identifying 13 metabolites from various chemical categories. Furthermore, the research incorporated the STRING database and Cytoscape software to perform a protein-protein interaction (PPI) analysis, pinpointing essential hub proteins involved in neuroprotection and inflammation in PD. Molecular docking and a 150 ns molecular dynamics simulation were performed to assess the interaction of plant-derived compounds with the Sirt-1 catalytic domain. Compound\n                    <jats:bold>12<\/jats:bold>\n                    , one of the bioactive compounds found in\n                    <jats:italic>T. aphylla<\/jats:italic>\n                    , exhibited strong binding affinity and stability throughout the 150 ns simulation, highlighting its role as a neuroprotective agent. This study underscores the fusion of computational and experimental techniques to investigate natural neuroprotective compounds, providing potential therapeutic strategies for PD treatment by influencing key pathways linked to oxidative damage and neuroinflammation.\n                  <\/jats:p>","DOI":"10.1371\/journal.pone.0339010","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T19:29:44Z","timestamp":1767727784000},"page":"e0339010","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Emphasizing the role of oxidative stress and Sirt-1\/Nrf2 and TLR-4\/NF-\u03baB in Tamarix aphylla mediated neuroprotective potential in rotenone-induced Parkinson\u2019s disease: In silico and in vivo study"],"prefix":"10.1371","volume":"21","author":[{"given":"Dalia H.","family":"Abu-Baih","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abeer H.","family":"Elmaidomy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hesham A.","family":"Abou-Zied","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nahla Abdelghany","family":"Hussien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manar I.","family":"Rasekh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Entesar A.","family":"Saber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sayed Fouad El-sheikh","family":"Ali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mostafa E.","family":"Rateb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omnia Magdy","family":"Hendawy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faisal H.","family":"Altemani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdullah H.","family":"Altemani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3583-5935","authenticated-orcid":true,"given":"Gerhard","family":"Bringmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Usama Ramadan","family":"Abdelmohsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6362-9266","authenticated-orcid":true,"given":"Omnia Hesham","family":"Abdelhafez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2026,1,6]]},"reference":[{"key":"pone.0339010.ref001","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.nbd.2017.04.004","article-title":"Alpha-synuclein: Pathology, mitochondrial dysfunction and neuroinflammation in Parkinson\u2019s disease","volume":"109","author":"EM Rocha","year":"2018","journal-title":"Neurobiol Dis"},{"key":"pone.0339010.ref002","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/bs.ctdb.2016.07.005","article-title":"Mechanisms of Parkinson\u2019s Disease: Lessons from Drosophila","volume":"121","author":"VL Hewitt","year":"2017","journal-title":"Curr Top Dev Biol"},{"key":"pone.0339010.ref003","doi-asserted-by":"crossref","first-page":"17013","DOI":"10.1038\/nrdp.2017.13","volume":"3","author":"W Poewe","year":"2017","journal-title":"Nat Rev Dis Primers"},{"issue":"8","key":"pone.0339010.ref004","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.1007\/s11011-022-01087-1","article-title":"AMPK-dependent autophagy activation and alpha-Synuclein clearance: a putative mechanism behind alpha-mangostin\u2019s neuroprotection in a rotenone-induced mouse model of Parkinson\u2019s disease","volume":"37","author":"P Parekh","year":"2022","journal-title":"Metab Brain Dis"},{"issue":"1","key":"pone.0339010.ref005","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/nrn3406","article-title":"The many faces of \u03b1-synuclein: from structure and toxicity to therapeutic target","volume":"14","author":"HA Lashuel","year":"2013","journal-title":"Nat Rev Neurosci"},{"key":"pone.0339010.ref006","doi-asserted-by":"crossref","unstructured":"Bakhsh HT, Abu-Baih DH, Abu-Baih RH, Saber EA, Altemani FH, Algehainy NA, et al. 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