{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T18:30:17Z","timestamp":1766773817641,"version":"3.48.0"},"reference-count":28,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T00:00:00Z","timestamp":1766707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study aimed to evaluate the effect of tannic acid on colonic anastomosis in a sepsis model induced by cecal abrasion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>Thirty Sprague-Dawley rats were used. The animals were randomly divided into three groups of ten: Group 1 (n:10): Colonic anastomosis\u2009+\u20090.9% isotonic NaCl. Group 2 (n:10): Cecal ligation and puncture\u2009+\u2009Colonic anastomosis\u2009+\u20090.9% isotonic NaCl. Group 3 (n:10): Cecal ligation and puncture\u2009+\u2009Colonic anastomosis\u2009+\u2009Tannic Acid group. The rats were sacrificed on the fifth postoperative day, and the resected colon segments, bursting pressure, hydroxyproline levels, and histopathologic features of the anastomosis were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The bursting pressure value was statistically significantly higher in Group 3, where tannic acid was administered (p\u2009&lt;\u20090.05). Group 2 and Group 3, in which peritonitis was induced, had moderate levels of fibroblastic activity, inflammatory cell infiltration, neovascularisation, and collagen; whereas, they were higher in Group 1. Although the inflammation value dropped in Group 3 compared to Groups 1 and 2, there was no statistical difference in Group 2. The hydroxyproline values were 2.046\u2009\u00b1\u20091.1411 mcg\/gr and 5.9730\u2009\u00b1\u20094.35900 mcg\/gr tissues, respectively, in Groups 2 and 3, where septic conditions prevailed, and a statistically significant difference was found (p\u2009&lt;\u20090.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This experimental study revealed that the use of tannic acid during anastomosis has a positive effect on wound healing, acting through higher colonic anastomotic bursting pressures and higher tissue hydroxyproline levels.<\/jats:p>\n                  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