{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:53:43Z","timestamp":1790744023186,"version":"4.1.0"},"reference-count":15,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:00:00Z","timestamp":1770768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005937","name":"Cheng Hsin General Hospital","doi-asserted-by":"crossref","award":["CHGH114-113-N23"],"award-info":[{"award-number":["CHGH114-113-N23"]}],"id":[{"id":"10.13039\/501100005937","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:p>Monitoring bone mineral density (BMD) changes can be challenging when both the spine and hips are included in follow-up assessments. This study aimed to evaluate BMD changes using different monitoring approaches, including comparisons between the mean bilateral total hip BMD and total hip BMD of each hip separately, spinal BMD and mean bilateral total hip BMD, and spinal BMD and trabecular bone score (TBS). Bone density was measured using dual-energy X-ray absorptiometry, and bone quality was assessed using the TBS. A total of 1,105 postmenopausal women who underwent simultaneous follow-up BMD measurements of the spine and both hips were retrospectively analyzed. In follow-up BMD measurements, the discordance between the mean bilateral total hip BMD and the individual total hip BMDs (right and left hips) was 11.3% when the least significant change (LSC) of the mean bilateral total hip was applied. In contrast, this discordance increased to 19.5% when the average LSC of the right and left hips was used. Spine-hip discordance was also observed, with a 43.5% discordance rate between changes in spinal BMD and mean bilateral total hip BMD. Additionally, discordance between changes in spinal BMD and TBS was noted, with a discordance rate of 58.0%. Analyzing each hip separately is more sensitive to detecting changes than using the mean bilateral total hip BMD. When monitoring mean bilateral total hip BMD on repeat tests, the LSC of the mean bilateral total hip BMD is recommended. Discordance between spine and hip BMD, as well as between spinal BMD and TBS, was observed in follow-up measurements.<\/jats:p>","DOI":"10.1371\/journal.pone.0339343","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T18:39:05Z","timestamp":1770835145000},"page":"e0339343","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparison of different methods for monitoring changes in bone mineral density during follow-up measurements"],"prefix":"10.1371","volume":"21","author":[{"given":"Yen-Huai","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3929-0178","authenticated-orcid":true,"given":"Michael Mu Huo","family":"Teng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,2,11]]},"reference":[{"issue":"10","key":"pone.0339343.ref001","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1007\/s11606-017-4094-y","article-title":"Incidence and Predictors of Repeat Bone Mineral Densitometry: A Longitudinal Cohort Study","volume":"32","author":"EC White VanGompel","year":"2017","journal-title":"J Gen Intern Med"},{"key":"pone.0339343.ref002","author":"The International Society for Clinical Densitometry","year":"2023"},{"issue":"9","key":"pone.0339343.ref003","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1007\/s00198-014-2725-2","article-title":"Overuse of short-interval bone densitometry: assessing rates of low-value care","volume":"25","author":"NE Morden","year":"2014","journal-title":"Osteoporos Int"},{"issue":"4","key":"pone.0339343.ref004","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.jocd.2019.07.006","article-title":"Dual-energy X-ray Absorptiometry Monitoring with Trabecular Bone Score: 2019 ISCD Official Position","volume":"22","author":"K Krohn","year":"2019","journal-title":"J Clin Densitom"},{"issue":"3","key":"pone.0339343.ref005","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1002\/jbmr.2176","article-title":"Trabecular bone score: a noninvasive analytical method based upon the DXA image","volume":"29","author":"BC Silva","year":"2014","journal-title":"J Bone Miner Res"},{"issue":"1","key":"pone.0339343.ref006","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.jocd.2021.07.006","article-title":"Dual Hip DXA. Is it Time to Change Standard Protocol?","volume":"25","author":"W Chen","year":"2022","journal-title":"J Clin Densitom"},{"issue":"6","key":"pone.0339343.ref007","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1007\/s00198-014-2685-6","article-title":"TBS result is not affected by lumbar spine osteoarthritis","volume":"25","author":"S Kolta","year":"2014","journal-title":"Osteoporos Int"},{"issue":"6","key":"pone.0339343.ref008","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1007\/BF02652563","article-title":"Effect of osteoarthritis in the lumbar spine and hip on bone mineral density and diagnosis of osteoporosis in elderly men and women","volume":"7","author":"G Liu","year":"1997","journal-title":"Osteoporos Int"},{"issue":"23","key":"pone.0339343.ref009","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.1097\/00007632-199912010-00016","article-title":"Degenerative lumbar listhesis and bone mineral density in elderly women. The study of osteoporotic fractures","volume":"24","author":"MT Vogt","year":"1999","journal-title":"Spine (Phila Pa 1976)"},{"key":"pone.0339343.ref010","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1472-6874-10-25","article-title":"Relationship between spine osteoarthritis, bone mineral density and bone turn over markers in post menopausal women","volume":"10","author":"L Ichchou","year":"2010","journal-title":"BMC Womens Health"},{"issue":"12","key":"pone.0339343.ref011","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1136\/jcp.2010.077842","article-title":"The pathogenesis, diagnosis, investigation and management of osteoporosis","volume":"64","author":"SK Sandhu","year":"2011","journal-title":"J Clin Pathol"},{"issue":"1","key":"pone.0339343.ref012","first-page":"9","article-title":"Primary osteoporosis in postmenopausal women","volume":"1","author":"M-X Ji","year":"2015","journal-title":"Chronic Dis Transl Med"},{"key":"pone.0339343.ref013","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s12891-016-0886-1","article-title":"Simulated increased soft tissue thickness artefactually decreases trabecular bone score: a phantom study","volume":"17","author":"S Amnuaywattakorn","year":"2016","journal-title":"BMC Musculoskelet Disord"},{"issue":"12","key":"pone.0339343.ref014","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1002\/jbmr.3851","article-title":"Clinical Performance of the Updated Trabecular Bone Score (TBS) Algorithm, Which Accounts for the Soft Tissue Thickness: The OsteoLaus Study","volume":"34","author":"E Shevroja","year":"2019","journal-title":"J Bone Miner Res"},{"issue":"11","key":"pone.0339343.ref015","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.1007\/s00198-013-2384-8","article-title":"Generation and validation of a normative, age-specific reference curve for lumbar spine trabecular bone score (TBS) in French women","volume":"24","author":"R Dufour","year":"2013","journal-title":"Osteoporos Int"}],"container-title":["PLOS One"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0339343","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T18:39:09Z","timestamp":1770835149000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0339343"}},"subtitle":[],"editor":[{"given":"Gaetano Paride","family":"Arcidiacono","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,2,11]]},"references-count":15,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,2,11]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0339343","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,11]]}}}