{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:21:56Z","timestamp":1787062916428,"version":"build-2736575974"},"reference-count":38,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study evaluated the clinical features, management, and outcomes of pregnant women with generalized tonic-clonic seizures presenting to the emergency department (ED). The aim was to demonstrate how patients\u2019 clinical features contribute to patient management and prognosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective study, pregnant women over the age of 18 who presented to the ED with generalized tonic-clonic seizures were included. The patients\u2019 demographic characteristics, clinical findings, treatments administered in the ED, and outcomes were recorded. Descriptive statistics, the chi-square tests or Fisher\u2019s exact tests for categorical variables and the Mann\u2013Whitney U or t-test for continuous variables were used in the statistical analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The study included 48 patients, most of whom were in their third trimester. Thirty-three (69%) patients had a history of epilepsy, and 28 (58.3%) were using antiseizure medications (ASMs). The most commonly used ASM was levetiracetam. Seven (14.6%) patients had suspected eclampsia, and seizure control was achieved in four of them by administering ASMs in addition to magnesium sulfate treatment. Two (4.2%) patients developed status epilepticus (SE). A significant relationship was observed between gestational age and hospitalization (p\u2009=\u20090.005).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The diagnostic complexity of epileptic seizures in pregnancy complicates treatment choices, and ASM use may also be beneficial in managing eclampsia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0339402","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T18:33:57Z","timestamp":1768934037000},"page":"e0339402","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pregnancy and epileptic seizures in the emergency department setting: A retrospective 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