{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T18:55:47Z","timestamp":1766084147991,"version":"3.48.0"},"reference-count":57,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017594","name":"Medical Science and Technology Project of Zhejiang Province","doi-asserted-by":"publisher","award":["2025C02188"],"award-info":[{"award-number":["2025C02188"]}],"id":[{"id":"10.13039\/501100017594","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012175","name":"Zhejiang Traditional Chinese Medicine Administration","doi-asserted-by":"publisher","award":["No. GZY-ZJ-KJ-24070"],"award-info":[{"award-number":["No. GZY-ZJ-KJ-24070"]}],"id":[{"id":"10.13039\/501100012175","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017531","name":"Medical and Health Research Project of Zhejiang Province","doi-asserted-by":"publisher","award":["2022KY234"],"award-info":[{"award-number":["2022KY234"]}],"id":[{"id":"10.13039\/501100017531","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Research Project of Zhejiang Chinese Medical University","award":["2025JKZKTS65"],"award-info":[{"award-number":["2025JKZKTS65"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:p>\n                    Sepsis and COVID-19 are the two mutually-reinforcing risk factors, whose interaction drastically increases mortality rate. Jinhong decoction (JHD) as a Chinese medicine exhibits clinical efficacy against them, but related action mechanism remains to be explored. To this end, using network pharmacology, this study screened active ingredients of JHD and their targets from TCMSP, HERB, PubChem and SwissTargetPrediction databases as well as the targets for these two diseases from DisGeNET, OMIM, Drugbank, TTD, and GeneCards. By intersecting drug and disease targets, we identified common targets and constructed a drug-ingredient-target network. GO and KEGG enrichment analyses revealed key target-related signaling pathways, and transcriptomics analysis further validated tissue distribution of these targets and their expressions. Our identified six key target genes (\n                    <jats:italic>AKT1<\/jats:italic>\n                    ,\n                    <jats:italic>MMP9<\/jats:italic>\n                    ,\n                    <jats:italic>ICAM1<\/jats:italic>\n                    ,\n                    <jats:italic>TLR4<\/jats:italic>\n                    ,\n                    <jats:italic>BCL2<\/jats:italic>\n                    , and\n                    <jats:italic>HIF1A<\/jats:italic>\n                    ) were mainly involved in the regulations of immunometabolism, inflammation, and cell survival in both diseases. Functional enrichment analysis indicated that JHD displayed synergistic efficacy against both diseases by simultaneously modulating HIF-1, TNF, and NF-\u03baB signaling pathways. Tissue distribution analyses of these 6 key target genes revealed that CD33\u2009+\u2009myeloid cells, fetal lung cells, and bronchial epithelial cells might play an important role in treating both diseases. Overall, this study demonstrates that JHD treats sepsis and COVID-19 through a multi-ingredient, multi-target, and multi-pathway inter-related mechanism, exhibiting a great application potential.\n                  <\/jats:p>","DOI":"10.1371\/journal.pone.0339457","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T18:38:47Z","timestamp":1766083127000},"page":"e0339457","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Analysis of molecular mechanism of Chinese medicine Jinhong decoction (JHD) in synergistically treating sepsis and COVID-19 based on network 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Sherman","year":"2024","journal-title":"Bioinformatics"},{"key":"pone.0339457.ref027","author":"IY Gong","year":"2017","journal-title":"Prediction of early breast cancer patient survival using ensembles of hypoxia signatures"},{"key":"pone.0339457.ref028","article-title":"BioGPS: building your own mash-up of gene annotations and expression profiles","volume":"44","author":"C Wu","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"pone.0339457.ref029","doi-asserted-by":"crossref","first-page":"1226159","DOI":"10.3389\/fcimb.2023.1226159","article-title":"Classification of subtypes and identification of dysregulated genes in sepsis","volume":"13","author":"R Tong","year":"2023","journal-title":"Front Cell Infect Microbiol"},{"key":"pone.0339457.ref030","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.humimm.2017.03.010","article-title":"Modulation of LILRB2 protein and mRNA expressions in septic shock patients and after ex vivo lipopolysaccharide 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TNF-\u03b1-Stimulated NCI-H292 Cells","volume":"9","author":"B-W Lee","year":"2020","journal-title":"Antioxidants (Basel)"},{"issue":"10","key":"pone.0339457.ref037","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.3390\/ph15101222","article-title":"Candesartan Attenuates Cisplatin-Induced Lung Injury by Modulating Oxidative Stress, Inflammation, and TLR-4\/NF-\u03baB, JAK1\/STAT3, and Nrf2\/HO-1 Signaling","volume":"15","author":"AM Atwa","year":"2022","journal-title":"Pharmaceuticals (Basel)"},{"issue":"12","key":"pone.0339457.ref038","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1111\/nep.14381","article-title":"PPAR gamma and PGC-1alpha activators protect against diabetic nephropathy by suppressing the inflammation and NF-kappaB activation","volume":"29","author":"S Huang","year":"2024","journal-title":"Nephrology 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Mi","year":"2019","journal-title":"Inflamm Res"},{"issue":"1","key":"pone.0339457.ref042","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1186\/s12964-024-01620-y","article-title":"Endothelial cell dynamics in sepsis-induced acute lung injury and acute respiratory distress syndrome: pathogenesis and therapeutic implications","volume":"22","author":"X Qiao","year":"2024","journal-title":"Cell Commun Signal"},{"key":"pone.0339457.ref043","doi-asserted-by":"crossref","first-page":"108080","DOI":"10.1016\/j.compbiomed.2024.108080","article-title":"Possible pharmacological targets and mechanisms of sivelestat in protecting acute lung injury","volume":"170","author":"J Ren","year":"2024","journal-title":"Comput Biol Med"},{"issue":"1","key":"pone.0339457.ref044","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/s12964-025-02149-4","article-title":"An examination of the LPS-TLR4 immune response through the analysis of molecular structures and protein-protein 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