{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T19:15:21Z","timestamp":1767726921940,"version":"3.48.0"},"reference-count":24,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Shanghai Jinshan District Science and Technology Committee","award":["2023-WS-07"],"award-info":[{"award-number":["2023-WS-07"]}]},{"name":"Jinshan District Health Commission","award":["JSZK2023A02"],"award-info":[{"award-number":["JSZK2023A02"]}]},{"name":"Jinshan Hospital","award":["KYQDJJ202501"],"award-info":[{"award-number":["KYQDJJ202501"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Minimal hepatic encephalopathy (MHE) is a frequent neurocognitive complication in chronic hepatic schistosomiasis (CHS) patients. Conventional diagnostic tools are time-consuming and influenced by education level. Quantitative MRI mapping offers a potential non-invasive biomarker for MHE, but its role in CHS remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study aimed to evaluate the diagnostic value of quantitative T1 and T2 mapping for detecting MHE in CHS patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective cross-sectional observational study was conducted from August 2023 to July 2024. A total of 88 CHS patients were enrolled and divided into MHE (n\u2009=\u200950) and non-MHE group (n\u2009=\u200938). MHE was assessed using the number connection test-A (NCT-A) and digit symbol test (DST). All participants underwent 3.0T MRI with T1 and T2 mapping. Group comparisons, correlation analyses, logistic regression, and receiver operating characteristic (ROC) curve analyses were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>MHE patients exhibited significantly lower T1 values across multiple brain regions, particularly the globus pallidus (all p\u2009&lt;\u20090.001). T2 values showed no significant differences between groups. Multivariable regression confirmed that lower T1 values were independently associated with MHE (p\u2009=\u20090.009). ROC analysis demonstrated excellent diagnostic performance of globus pallidus T1 values (AUC\u2009=\u20090.92, 95% CI: 0.86\u20130.99), with sensitivity of 0.97 and specificity of 0.90. T1 values were also correlated with neuropsychological tests (NCT-A: r\u2009=\u2009\u22120.345, p\u2009&lt;\u20090.001; DST: r\u2009=\u20090.232, p\u2009=\u20090.029). However, T2 values showed no significant group differences or diagnostic value.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec005\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Quantitative T1 mapping, rather than T2 mapping, could be used as a potential non-invasive biomarker for detecting MHE in CHS patients. This approach offers an objective complement to psychometric testing and may facilitate earlier diagnosis and monitoring of MHE progression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0339588","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T19:12:21Z","timestamp":1767726741000},"page":"e0339588","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["The role of quantitative T1 and T2 mapping for detecting minimal hepatic encephalopathy in chronic hepatic schistosomiasis 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