{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T06:19:09Z","timestamp":1768630749189,"version":"3.49.0"},"reference-count":32,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00c3\u00a7\u00c3\u00a3o de Amparo \u00c3\u00a0 Pesquisa do Estado de S\u00c3\u00a3o Paulo","doi-asserted-by":"publisher","award":["24\/04564-0"],"award-info":[{"award-number":["24\/04564-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Instituto Todos pela Sa\u00c3\u00bade","award":["C1721"],"award-info":[{"award-number":["C1721"]}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00c3\u00a7\u00c3\u00a3o de Amparo \u00c3\u00a0 Pesquisa do Estado de S\u00c3\u00a3o Paulo","doi-asserted-by":"publisher","award":["22\/01769-5"],"award-info":[{"award-number":["22\/01769-5"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The National Council for Scientific and Technological Development","award":["304743\/2017-8"],"award-info":[{"award-number":["304743\/2017-8"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The skeletal muscles and kidneys are frequently affected during critical illness; however, their crosstalk remains poorly explored, especially in the long-term evolution. Therefore, we investigated the crosstalk between skeletal muscle and kidney function in COVID-19 survivors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A cross-sectional analysis of a prospective cohort study with\n                      <jats:bold>s<\/jats:bold>\n                      urvivors of moderate to severe COVID-19 hospitalization. Skeletal muscle assessments included handgrip strength, calf circumference, ultrasound-measured quadriceps thickness, and gait speed test. Sarcopenia was diagnosed by modified EWGSOP2 (low handgrip strength\n                      <jats:italic>plus<\/jats:italic>\n                      low ultrasound-measured quadriceps thickness). Kidney function was assessed by estimated glomerular filtration rate (eGFR), urinary albumin-to-creatinine ratio (UACR), and urine sediment analysis. Abnormal kidney function was defined as an eGFR\u2009&lt;\u200960\u2009mL\/min\/1.73m\n                      <jats:sup>2<\/jats:sup>\n                      , albuminuria (\u226530\u2009mg\/g), and\/or leukocyturia or hematuria.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 734 survivors (46% female, 43%\u2009\u2265\u200960 years, 35% with diabetes) were assessed 7\u2009\u00b1\u20092 months post-hospital discharge. Sarcopenia was diagnosed in 21.4% of the cohort. Positive significant associations with eGFR were observed for calf circumference (\u03b2\u2009=\u20090.42\u2009ml\/min\/1.73m\n                      <jats:sup>2<\/jats:sup>\n                      , 95%CI: 0.06 to 0.78) and thicknesses (mm) of rectus femoris (\u03b2\u2009=\u20090.47, 95%CI: 0.01 to 0.94) and vastus intermedius (\u03b2\u2009=\u20090.55, 95%CI: 0.14 to 0.96). None of the skeletal muscle parameters were associated with UACR (mg\/g). Survivors with sarcopenia had lower eGFR (\u20125.8\u2009ml\/min\/1.73m\n                      <jats:sup>2<\/jats:sup>\n                      , 95%CI: \u201210.8 to \u20120.9), but similar frequencies of low eGFR (24%\n                      <jats:italic>vs<\/jats:italic>\n                      . 18%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.137), albuminuria (27%\n                      <jats:italic>vs<\/jats:italic>\n                      . 31%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.434) and abnormal urine sediment (17%\n                      <jats:italic>vs<\/jats:italic>\n                      . 22%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.217) as compared to those without sarcopenia. Sarcopenia was not associated with higher odds of low eGFR, albuminuria, or abnormal urine sediment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      In survivors of moderate to severe COVID-19 hospitalization, skeletal muscle mass was associated with eGFR, whereas sarcopenia\n                      <jats:italic>per se<\/jats:italic>\n                      was not independently associated with poor kidney function. These findings suggest the existence of a skeletal muscle-kidney crosstalk in this population.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0339795","type":"journal-article","created":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T18:24:02Z","timestamp":1768587842000},"page":"e0339795","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Skeletal muscle-kidney crosstalk in a cohort of critical illness survivors"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4019-4490","authenticated-orcid":true,"given":"Heitor S.","family":"Ribeiro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3605-0571","authenticated-orcid":true,"given":"D\u00e1rio R.","family":"Mondini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guilherme P.","family":"Santa-Catharina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lia","family":"Mar\u00e7al","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leila","family":"Anton\u00e2ngelo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirce M. T.","family":"Zanetta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5275-0733","authenticated-orcid":true,"given":"Linamara R.","family":"Battistella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geraldo F.","family":"Busatto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1618-8509","authenticated-orcid":true,"given":"Carlos R. R.","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuel A.","family":"Burdmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"for the HCFMUSP COVID-19 Study Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2026,1,16]]},"reference":[{"key":"pone.0339795.ref001","unstructured":"WHO. 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