{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T05:47:17Z","timestamp":1788587237067,"version":"build-2803163510"},"reference-count":24,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:00:00Z","timestamp":1770595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"New Variety Development Project of Amway (China) Botanical R&D Centre.","award":["No.BC20220016Z"],"award-info":[{"award-number":["No.BC20220016Z"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:p>\n                    Chrysanthemum is a globally significant economical crop. Through broadly targeted metabolomics, 58 polyphenols and 65 xanthophylls were quantitatively and qualitatively assessed in chrysanthemum petals. Carotenoids including \u03b2-cryptoxanthin, lutein stearate, lutein distearate, lutein dioleate, and lutein oleate, emerged as the primary compounds in both ligulate and tubular flowers, and their levels remaining relatively high and stable during the second to fifth stages of chrysanthemum flower development. However, the compound content varied across developmental stages and tissues. Additionally, the activity of a novel chrysanthemum cultivar extract was evaluated; at a concentration of 62.5 \u03bcg\/mL, it exhibited significantly greater anti-apoptotic effects than glutathione (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Moreover, various concentrations of the chrysanthemum extract demonstrated a clear trend in preventing retinopathy. This study integrated chemical composition analysis with activity evaluation to offer fresh insights into the mechanism underlying the development of eye-protecting agents derived from chrysanthemum flowers.\n                  <\/jats:p>","DOI":"10.1371\/journal.pone.0340052","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T18:37:27Z","timestamp":1770662247000},"page":"e0340052","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Integrated metabolomics and bioactivity analysis of new chrysanthemum cultivar petals: Insights into eye-protecting agents"],"prefix":"10.1371","volume":"21","author":[{"given":"Yifan","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hedi","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gangqiang","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuyin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyan","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1387-9133","authenticated-orcid":true,"given":"Sha","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,2,9]]},"reference":[{"issue":"1","key":"pone.0340052.ref001","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.foodchem.2009.09.083","article-title":"Identification of the phenolic components of chrysanthemum flower (Chrysanthemum morifolium Ramat)","volume":"120","author":"L-Z Lin","year":"2010","journal-title":"Food Chemistry"},{"issue":"8","key":"pone.0340052.ref002","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.3390\/antiox10081309","article-title":"Hypolipidemic Effects and Preliminary Mechanism of Chrysanthemum Flavonoids, Its Main Components Luteolin and Luteoloside in Hyperlipidemia Rats","volume":"10","author":"J Sun","year":"2021","journal-title":"Antioxidants (Basel)"},{"issue":"8","key":"pone.0340052.ref003","doi-asserted-by":"crossref","DOI":"10.1002\/cbdv.202100206","article-title":"Comparison of Chemical Constituents and Pharmacological Effects of Different Varieties of Chrysanthemum Flos in China","volume":"18","author":"L Chen","year":"2021","journal-title":"Chem Biodivers"},{"issue":"20","key":"pone.0340052.ref004","doi-asserted-by":"crossref","first-page":"2781","DOI":"10.1016\/j.phytochem.2004.08.038","article-title":"Carotenoid composition in petals of chrysanthemum (Dendranthema grandiflorum (Ramat.) 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