{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T13:52:57Z","timestamp":1781617977528,"version":"3.54.5"},"reference-count":44,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T00:00:00Z","timestamp":1767312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Skeletal Class III malocclusion is a severe dentofacial deformity that often requires surgical correction, but the associated risks have increased interest in non-surgical alternatives. The multiloop edgewise archwire (MEAW) technique has been used as a conservative option. The aim of this study was to investigate the dentoskeletal changes associated with the MEAW technique in treating skeletal Class III malocclusion, with a particular focus on improvements in anteroposterior bimaxillary relationships and comparison with surgical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study included 60 patients with skeletal Class III malocclusion, comprising 30 treated with the MEAW technique and 30 matched patients who underwent orthognathic surgery. Dentoskeletal parameters were assessed on pre- and post-treatment lateral cephalograms. Pearson\u2019s correlation analysis and multiple linear regression were performed to identify factors associated with improvements in anteroposterior relationships.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Significant dental and skeletal changes were observed, including alterations in incisor inclination and bimaxillary measurements (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Post-treatment, anteroposterior relationships improved significantly, with changes strongly associated with increases in the BaNA angle and decreases in the SNB angle. However, compared to the surgical group, the MEAW group demonstrated less pronounced improvements in anteroposterior bimaxillary relationships. Regression analysis identified the BaNA angle and incisor inclination as key contributors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Although the effect is less pronounced than in the case of surgical intervention, the MEAW technique effectively improves anteroposterior bimaxillary relationships in skeletal Class III malocclusion. These findings suggest that MEAW is a valuable non-surgical alternative for selected skeletal Class III patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0340197","type":"journal-article","created":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T18:46:46Z","timestamp":1767379606000},"page":"e0340197","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Dentoskeletal changes and anteroposterior improvements in skeletal class III malocclusion treated with MEAW: A retrospective study"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8405-8995","authenticated-orcid":true,"given":"Phi Ngoc Quang","family":"Tran","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anh Hoang","family":"Cu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minh Ngoc Thuy","family":"Tran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vy Ngoc Thuy","family":"Tran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,1,2]]},"reference":[{"issue":"3","key":"pone.0340197.ref001","first-page":"248","article-title":"Classification of malocclusion","volume":"41","author":"EH Angle","year":"1899","journal-title":"Dent Cosmos"},{"issue":"04","key":"pone.0340197.ref002","doi-asserted-by":"crossref","first-page":"75","DOI":"10.4236\/ojepi.2012.24012","article-title":"Prevalence of angle class III malocclusion: A systematic review and meta-analysis","volume":"02","author":"DK Hardy","year":"2012","journal-title":"OJEpi"},{"issue":"2","key":"pone.0340197.ref003","first-page":"121","article-title":"Stability of sagittal split ramus osteotomy used to correct Class III malocclusion: review of the literature","volume":"16","author":"F Costa","year":"2001","journal-title":"Int J Adult Orthodon Orthognath Surg"},{"issue":"2","key":"pone.0340197.ref004","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1007\/s12663-012-0457-4","article-title":"Evaluation of Post-operative Complication Rate of Le Fort I Osteotomy: A Retrospective and Prospective Study","volume":"13","author":"S Garg","year":"2014","journal-title":"J Maxillofac Oral Surg"},{"issue":"5","key":"pone.0340197.ref005","doi-asserted-by":"crossref","first-page":"3315","DOI":"10.1007\/s00784-020-03664-z","article-title":"Complications or rather side effects? 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