{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:17:23Z","timestamp":1792790243014,"version":"4.5.0"},"reference-count":29,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008463","name":"Universitas Airlangga","doi-asserted-by":"publisher","award":["345\/UN3.LPPM\/PT.01.03\/2024"],"award-info":[{"award-number":["345\/UN3.LPPM\/PT.01.03\/2024"]}],"id":[{"id":"10.13039\/501100008463","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Dr.Soetomo Academic General Hospital","award":["100.3.3\/25.1\/102.6\/2024"],"award-info":[{"award-number":["100.3.3\/25.1\/102.6\/2024"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Congenital anomalies of the kidney and urinary tract (CAKUT) are a significant cause of pediatric morbidity and mortality, often leading to chronic kidney disease (CKD). Accurate glomerular filtration rate (GFR) assessment is crucial for effective management, but a gold-standard pediatric GFR estimation formula remains elusive. This study compared the bedside Schwartz, Chronic Kidney Disease in Children (CKiD-U25) creatinine, and European Kidney Function Consortium (EKFC) creatinine-based equations against measured GFR (mGFR) using technetium-99m-diethylenetriaminepentaacetic acid (Tc-99mDTPA) clearance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data were collected from 276 children with CAKUT at Dr. Soetomo Academic General Hospital. Estimated GFR (eGFR) was calculated using the bedside Schwartz, CKiD-U25, and EKFC equations. mGFR was determined using Tc-99mDTPA clearance, considered the gold standard. Correlation (Spearman rs), bias, and accuracy (P30, percentage of eGFR within 30% of mGFR) were assessed. Subgroup analysis was performed for children older than two years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Both equations correlated significantly with mGFR (bedside Schwartz: r\u2009=\u20090.793; CKiD-U25: r\u2009=\u20090,793; EKFC: r\u2009=\u20090.745, p\u2009&lt;\u20090.0001). However, the bedside Schwartz systematically underestimated mGFR (bias: \u221221.7 mL\/min\/1.73 m\u00b2), while the EKFC overestimated (bias: 17 mL\/min\/1.73 m\u00b2, p\u2009&lt;\u20090.0001). In children &gt;2 years, correlations strengthened (bedside Schwartz: r\u2009=\u20090.804; EKFC: r\u2009=\u20090.835, p\u2009&lt;\u20090.0001), with the EKFC demonstrating more accuracy (P30: 90.1%) compared to the bedside Schwartz CKiD-U25 creatinine (75% and 75%, respectively)<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings suggest the both bedside Schwartz and EKFC could be a reliable tool for GFR estimation in this pediatric CAKUT population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0340649","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T19:18:53Z","timestamp":1767727133000},"page":"e0340649","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Performance of glomerular filtration rate equations using serum creatinine in children with congenital anomalies of the kidney and urinary tract"],"prefix":"10.1371","volume":"21","author":[{"given":"Ferdy Royland","family":"Marpaung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santi Wulan","family":"Purnami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shofi","family":"Andari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Rohman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hari Basuki","family":"Notobroto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1708-5384","authenticated-orcid":true,"given":"Risky Vitria","family":"Prasetyo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anggia Augustasia","family":"Lumban Toruan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Djoko","family":"Santoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9383-6354","authenticated-orcid":true,"given":"Aryati","family":"Aryati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,1,6]]},"reference":[{"issue":"7","key":"pone.0340649.ref001","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1007\/s00467-012-2115-y","article-title":"Native nephrectomy prior to pediatric kidney transplantation: biological and clinical aspects","volume":"27","author":"F Ghane Sharbaf","year":"2012","journal-title":"Pediatr 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