{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T22:04:12Z","timestamp":1769205852865,"version":"3.49.0"},"reference-count":8,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"\n Objective<\/jats:title>\n To investigate the clinical features, diagnostic approaches, and treatment strategies of spontaneous renal artery dissection (SRAD) through systematic review and data analysis, thereby providing evidence-based insights for optimizing clinical management.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A systematic search was conducted across PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure (CNKI), and Wanfang Database. Case-control studies, cohort studies, and case series were included. Demographic data, symptomatology, diagnostic modalities, treatment regimens, and clinical outcomes were extracted. Statistical analyses were performed using RStudio.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n A total of 73 case reports involving 97 patients were included. The mean patient age was 46 years, with a male predominance (82.5%, 80\/97). The most common presenting symptom was acute-onset flank pain (74.2%), and comorbid hypertension was observed in 61.9% of cases. Computed tomography angiography (CTA) was the primary diagnostic modality (85.6%), with multimodal imaging utilized in 87.6% of cases. Revascularization rates differed significantly between conservative management (37.1%), endovascular intervention (71.0%), and surgical intervention (6.2%) (P\u2009<\u20090.01). Regarding blood pressure outcomes: the proportion of patients achieving normotension without medication was significantly higher in the non-conservative group (54.1%, 20\/37) than in the conservative group (30.0%, 6\/20) (P\u2009<\u20090.05); however, there was no statistically significant disparity in the overall blood pressure control rate (normotension without medication\u2009+\u2009controlled with medication) between groups (P\u2009>\u20090.05). Overall mortality was 3.1%, and renal function deterioration occurred in 30.9% of patients.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Management of SRAD necessitates individualized decision-making. Conservative therapy remains appropriate for most patients, while endovascular intervention demonstrates superior revascularization efficacy in cases with severe symptomatology or dissection progression. Prospective studies are warranted to validate therapeutic disparities and establish standardized diagnostic and treatment protocols.<\/jats:p>\n <\/jats:sec>","DOI":"10.1371\/journal.pone.0340766","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T18:23:22Z","timestamp":1769192602000},"page":"e0340766","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical characteristics, diagnostic modalities, and therapeutic strategies of spontaneous renal artery dissection: A systematic review and diagnostic analysis"],"prefix":"10.1371","volume":"21","author":[{"given":"Jiahao","family":"Zhu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zengqiang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Geng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengxin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6492-9132","authenticated-orcid":true,"given":"Yingjiang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2026,1,23]]},"reference":[{"issue":"7","key":"pone.0340766.ref001","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/j.ajem.2011.06.041","article-title":"Renal infarction in the ED: 10-year experience and review of the literature","volume":"30","author":"M Antopolsky","year":"2012","journal-title":"Am J Emerg Med"},{"issue":"1","key":"pone.0340766.ref002","doi-asserted-by":"crossref","DOI":"10.1002\/ams2.466","article-title":"Urolithiasis mimic: isolated spontaneous renal artery dissection in the emergency department","volume":"7","author":"R Nakama","year":"2019","journal-title":"Acute Med Surg"},{"issue":"4","key":"pone.0340766.ref003","doi-asserted-by":"crossref","first-page":"605","DOI":"10.3346\/jkms.2017.32.4.605","article-title":"Spontaneous Renal Artery Dissection as a Cause of Acute Renal Infarction: Clinical and MDCT Findings","volume":"32","author":"K Yoon","year":"2017","journal-title":"J Korean Med Sci"},{"key":"pone.0340766.ref004","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2018-226230","article-title":"Spontaneous renal artery dissection masquerading as urinary tract infection","volume":"2018","author":"G Chamarthi","year":"2018","journal-title":"BMJ Case Rep"},{"issue":"2","key":"pone.0340766.ref005","article-title":"Isolated Renal Artery Dissection: A Systematic Review of Case Reports","volume":"12","author":"A Jha","year":"2020","journal-title":"Cureus"},{"issue":"7","key":"pone.0340766.ref006","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1177\/1538574417723155","article-title":"Endovascular Treatment of Spontaneous Renal Artery Dissection After Failure of Medical Management","volume":"51","author":"GA Vitiello","year":"2017","journal-title":"Vasc Endovascular Surg"},{"issue":"2","key":"pone.0340766.ref007","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s10016-001-0154-0","article-title":"Nonoperative management of acute spontaneous renal artery dissection","volume":"16","author":"SL Ramamoorthy","year":"2002","journal-title":"Ann Vasc Surg"},{"issue":"4","key":"pone.0340766.ref008","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1097\/01.RVI.0000064845.87207.70","article-title":"Spontaneous renal artery dissection: treatment with coil embolization","volume":"14","author":"D Mudrick","year":"2003","journal-title":"J Vasc Interv Radiol"}],"container-title":["PLOS One"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0340766","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T18:23:25Z","timestamp":1769192605000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0340766"}},"subtitle":[],"editor":[{"given":"Chiara","family":"Lazzeri","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2026,1,23]]},"references-count":8,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1,23]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0340766","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,23]]}}}