{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T23:10:32Z","timestamp":1768259432866,"version":"3.49.0"},"reference-count":54,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:p>\n                    Influenza is primarily a respiratory disease but can cause a broad spectrum of complications, including those affecting the cerebrovascular system. The aim of this study was to evaluate cerebrovascular reactivity in patients during and after influenza infection. A total of 92 participants, mean age 43 years, were enrolled; 46 patients with confirmed influenza infection and 46 healthy controls. Cerebrovascular reactivity was assessed using transcranial Doppler in combination with the breath-holding test and quantified by the breath-holding index (BHI). The influenza group demonstrated significantly lower cerebral blood flow velocities in the middle cerebral artery both at rest (PSVrest, MVrest,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) and after the breath-holding test (PSVmax, MVmax,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) compared to healthy controls. The BHI was also significantly reduced in the influenza group (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), indicating impaired cerebrovascular reactivity. Among participants reassessed three months post-recovery, blood flow velocities after the breath-holding test were significantly higher than during the acute phase (PSVmax, MVmax,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), and BHI also improved (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), suggesting restoration of cerebrovascular function. These findings suggest that influenza may transiently impair cerebrovascular reactivity, providing new insights into potential mechanisms influencing cerebrovascular function and hemodynamics.\n                  <\/jats:p>","DOI":"10.1371\/journal.pone.0340768","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T18:27:34Z","timestamp":1768242454000},"page":"e0340768","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of cerebrovascular reactivity using transcranial Doppler in patients with influenza"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-0059-9839","authenticated-orcid":true,"given":"Ana","family":"Orsolic 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