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This pilot study develops and preliminarily validates a novel tone-mapping algorithm for enhancing contrast resolution in high dynamic range (HDR) ultrasound images. The method employs multi-resolution fusion with depth-adaptive weighting and depth compensation to improve contrast, enhance tissue differentiation, reduce noise, and preserve fine details. The algorithm was tested on 20 fetal ultrasound images focused on fetal kidney visualization. Quantitative evaluation showed a 5.4% mean increase in entropy and mean generalized contrast-to-noise ratio (gCNR) improvements of 15.79%, 8.93%, and 17.39% between fetal kidneys and amniotic fluid, far-field objects and fluid, and fetal kidneys and adjacent tissues, respectively, compared with an existing method. These results demonstrate improved anatomical visualization, particularly of fetal kidneys, with potential clinical relevance.<\/jats:p>","DOI":"10.1371\/journal.pone.0340777","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T18:54:20Z","timestamp":1768935260000},"page":"e0340777","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Multi-resolution tone mapping for high dynamic range medical ultrasound images"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-3457-0201","authenticated-orcid":true,"given":"Thi Lan Nhi","family":"Vu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2331-776X","authenticated-orcid":true,"given":"Vimal","family":"Chandran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3557-5050","authenticated-orcid":true,"given":"Christina","family":"Haberl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Otmar","family":"Scherzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5725-9270","authenticated-orcid":true,"given":"Julia","family":"Binder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,1,20]]},"reference":[{"key":"pone.0340777.ref001","unstructured":"Adams A. 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