{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:50:41Z","timestamp":1791265841851,"version":"4.1.0"},"reference-count":46,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010652","name":"Holland Bloorview Kids Rehabilitation Hospital Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010652","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:p>Well-fitting sockets are crucial for successful upper-limb prosthesis use, yet current digital socket design workflows are not standardized and demand considerable clinician effort. In this study, we introduce the Predictive Algorithm for Customized Transradial Socket Design (PACT), which generates socket models from a 3D limb scan. It works by retrieving the most similar limb\u2013socket pair from a reference library of prosthetist-designed prosthetic sockets and applying isotropic and anisotropic scaling adjustments to match the input limb. To validate the algorithm, the PACT-predicted sockets for 19 participants were compared to their prosthetist-designed ones (the clinical \u201cgold standard\u201d) using the surface Euclidean (L2) distances, volume differences, and a 100-slice cross-sectional-area analysis. Localized discrepancies were mapped via signed-distance colorization and clustered with DBSCAN. PACT\u2019s outputs differed from prosthetist designs by 2.11\u2009\u00b1\u20090.51\u2009mm on the surface and 2.74\u2009\u00b1\u20092.56% in volume on average; slice-wise area differences were within \u00b110% for most of the socket length, with larger errors near the proximal trimline and distal tip. Recurrent localized discrepancies were found to be concentrated at the anterior-distal trimline (15\/19 cases) and anterior\u2013posterior compression (11\/19 cases), indicating clear targets for rule-based or measurement-informed refinements. Subgroup patterns suggested an age-related bias (undersizing in pediatric, oversizing in adults). Overall, PACT quickly delivers (13.2\u2009\u00b1\u20090.7\u2009s) a first-draft transradial socket within commonly cited clinical fit tolerances. Focus on specific regions, along with metadata such as tissue stiffness, age, and clinician-led measurements, can improve personalization and generalizability in future iterations of the PACT.<\/jats:p>","DOI":"10.1371\/journal.pone.0340831","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T18:26:47Z","timestamp":1767896807000},"page":"e0340831","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["PACT: A practice-driven predictive algorithm for customized transradial prosthetic socket design"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1817-2620","authenticated-orcid":true,"given":"Vishal","family":"Pendse","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8645-9530","authenticated-orcid":true,"given":"Calvin 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