{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T08:11:06Z","timestamp":1769587866617,"version":"3.49.0"},"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 81860233"],"award-info":[{"award-number":["No. 81860233"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Lanzhou Science and Technology Bureau's special medical and health project","award":["No. 2023-1-47"],"award-info":[{"award-number":["No. 2023-1-47"]}]},{"DOI":"10.13039\/501100004775","name":"Gansu Provincial Natural Science Foundation","doi-asserted-by":"crossref","award":["No. 21JR7RA621"],"award-info":[{"award-number":["No. 21JR7RA621"]}],"id":[{"id":"10.13039\/501100004775","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Gansu Province Anesthesia and Brain Function Clinical Medical Research Center","award":["No. 21JR7RA675"],"award-info":[{"award-number":["No. 21JR7RA675"]}]},{"name":"Key Research and Development Plan of Gansu Province - Social Development Category","award":["No. 23YFFA0046"],"award-info":[{"award-number":["No. 23YFFA0046"]}]},{"name":"Gansu Province Key Talent Project","award":["No. 2023RCXM13"],"award-info":[{"award-number":["No. 2023RCXM13"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This double-blinded randomized study aimed to investigate the effects of esketamine-based patient-controlled intravenous analgesia (PCIA) on postoperative analgesia and quality of recovery in patients undergoing video-assisted thoracoscopic (VATS) lobectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients undergoing selective VATS lobectomy were enrolled and randomly assigned (1:1) to receive PICA with 1.5 mg\/kg esketamine (group K) or 1.5 mg\/kg sufentanil (group S). Pain intensity was evaluated using the short-form of the McGill Pain Questionnaire (SF-MPQ) and the visual analog scale (VAS). The primary endpoint was the SF-MPQ score of patients on postoperative day 1.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Between December 2021 and May 2022, 84 eligible patients received the allocated treatment, with 80 patients (40 per group) ultimately included in the analysis. The total SF-MPQ score in group K was lower than that in group S on postoperative day 1 (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) and day 2 (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). Additionally, the VAS-rest, VAS-movement and patients\u2019 depression-related scores in group K were all significantly lower than those in group S on postoperative day 1 (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.012,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.008 and\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.009, respectively) and day 2 (all\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001), whereas the postoperative recovery quality was significantly higher in group K than that in group S on postoperative days 1 and 2 (both\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). A lower incidence of total adverse events (AEs) was observed in group K than in group S (15%\n                      <jats:italic>vs.<\/jats:italic>\n                      35%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.039).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The use of 1.5 mg\/kg esketamine in PCIA for postoperative analgesia in patients undergoing VATS lobectomy showed a promising analgesic effect and improved perioperative depression and postoperative recovery quality, with no severe AEs observed.<\/jats:p>\n                  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