{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T08:08:42Z","timestamp":1769587722610,"version":"3.49.0"},"reference-count":52,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate the effect of autologous platelet-rich plasma (PRP) eye drops on optical quality and visual acuity in eyes implanted with a trifocal diffractive intraocular lens (IOL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective cohort study of 128 eyes from 128 patients undergoing femtosecond laser-assisted cataract surgery with implantation of the CNWT Clareon PanOptix (Alcon Inc.) IOL, patients were assigned to one of two groups: the PRP group (n\u2009=\u200962), which received postoperative PRP eye drops, and the conventional treatment group (n\u2009=\u200966). At 3 weeks postoperatively, optical parameters\u2014including the objective scatter index (OSI), modulation transfer function (MTF) cutoff, and Strehl ratio (SR)\u2014were measured with a double-pass system. Uncorrected distance visual acuity (UDVA) and corrected distance visual acuity (CDVA) at 4 m, as well as uncorrected near visual acuity (UNVA) at 40 cm, were recorded in logMAR units.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The PRP group demonstrated superior optical quality across all measured parameters compared to the control group, with lower OSI (1.60 vs. 3.14), higher MTF cutoff (31.93 vs. 19.90 cycles\/degree), and higher SR (0.15 vs. 0.12) (all\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). Visual acuity was also significantly better in the PRP group, with lower mean logMAR UDVA (0.05 vs. 0.10;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001), CDVA (0.01 vs. 0.05;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001), and UNVA (0.13 vs. 0.18;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.007). Multivariate analyses confirmed that the use of PRP eye drops was independently associated with improvements in all three optical parameters: OSI (B\u2009=\u2009\u22121.488), MTF cutoff (B\u2009=\u200912.038), and SR (B\u2009=\u20090.039) (all\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The use of autologous PRP eye drops improves optical quality and visual acuity at all distances following trifocal diffractive IOL implantation. PRP eye drops may serve as a beneficial adjunct for postoperative management in patients undergoing this procedure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0340880","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T18:23:16Z","timestamp":1769538196000},"page":"e0340880","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of autologous platelet-rich plasma on optical quality and visual outcomes following implantation of a trifocal diffractive intraocular lens"],"prefix":"10.1371","volume":"21","author":[{"given":"Kun-Hoo","family":"Na","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo Young","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hye Jin","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3620-1536","authenticated-orcid":true,"given":"Joon Young","family":"Hyon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2026,1,27]]},"reference":[{"issue":"11","key":"pone.0340880.ref001","doi-asserted-by":"crossref","DOI":"10.1016\/j.ophtha.2020.09.026","article-title":"Multifocal and extended depth-of-focus intraocular lenses in 2020","volume":"128","author":"R Rampat","year":"2021","journal-title":"Ophthalmology"},{"key":"pone.0340880.ref002","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.ajo.2017.09.016","article-title":"Visual Performance of a quadrifocal (trifocal) intraocular lens following removal of the crystalline lens","volume":"184","author":"T Kohnen","year":"2017","journal-title":"Am J Ophthalmol"},{"key":"pone.0340880.ref003","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.ajo.2017.04.013","article-title":"Visual outcomes following bilateral lmplantation of two diffractive trifocal intraocular lenses in 10 084 eyes","volume":"179","author":"R Bilbao-Calabuig","year":"2017","journal-title":"Am J Ophthalmol"},{"issue":"7","key":"pone.0340880.ref004","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1136\/bjophthalmol-2021-319732","article-title":"Rethinking presbyopia: results of bilateral refractive lens exchange with trifocal intraocular lenses in 17 603 patients","volume":"107","author":"LF Brenner","year":"2023","journal-title":"Br J Ophthalmol"},{"issue":"3","key":"pone.0340880.ref005","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1167\/tvst.11.3.14","article-title":"A novel intraocular lens simulator that allows patients to experience the world through multifocal intraocular lenses before surgeries","volume":"11","author":"K-S Na","year":"2022","journal-title":"Transl Vis Sci Technol"},{"issue":"1","key":"pone.0340880.ref006","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1186\/s12886-020-01446-5","article-title":"How does the world appear to patients with multifocal intraocular lenses?: A mobile model eye experiment","volume":"20","author":"EC Kim","year":"2020","journal-title":"BMC Ophthalmol"},{"issue":"7","key":"pone.0340880.ref007","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1167\/tvst.12.7.5","article-title":"Comparative analysis of optical quality of monofocal, enhanced monofocal, multifocal, and extended depth of focus intraocular lenses: A mobile model eye study","volume":"12","author":"EC Kim","year":"2023","journal-title":"Transl Vis Sci Technol"},{"issue":"5","key":"pone.0340880.ref008","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.survophthal.2017.03.005","article-title":"Multifocal intraocular lenses: An overview","volume":"62","author":"JL Alio","year":"2017","journal-title":"Surv Ophthalmol"},{"issue":"8","key":"pone.0340880.ref009","doi-asserted-by":"crossref","DOI":"10.1111\/aos.12710","article-title":"Autologous serum and plasma rich in growth factors in ophthalmology: Preclinical and clinical studies","volume":"93","author":"E Anitua","year":"2015","journal-title":"Acta Ophthalmol"},{"key":"pone.0340880.ref010","article-title":"Platelets, inflammation and tissue regeneration","author":"AT Nurden","year":"2011","journal-title":"Thromb Haemost"},{"issue":"6","key":"pone.0340880.ref011","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1007\/s10384-012-0175-y","article-title":"Effect of autologous platelet-rich plasma on persistent corneal epithelial defect after infectious keratitis","volume":"56","author":"KM Kim","year":"2012","journal-title":"Jpn J Ophthalmol"},{"issue":"4","key":"pone.0340880.ref012","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1097\/ICU.0000000000000169","article-title":"Eye platelet-rich plasma in the treatment of ocular surface disorders","volume":"26","author":"JL Alio","year":"2015","journal-title":"Curr Opin Ophthalmol"},{"issue":"1","key":"pone.0340880.ref013","doi-asserted-by":"crossref","first-page":"8906","DOI":"10.1038\/s41598-022-12879-x","article-title":"Comparison of epitheliotrophic factors in platelet-rich plasma versus autologous serum and their treatment efficacy in dry eye disease","volume":"12","author":"C Metheetrairut","year":"2022","journal-title":"Sci Rep"},{"issue":"1","key":"pone.0340880.ref014","doi-asserted-by":"crossref","first-page":"19279","DOI":"10.1038\/s41598-023-46671-2","article-title":"Efficacy and safety of platelet-rich plasma and autologous-serum eye drops for dry eye in primary Sj\u00f6gren\u2019s syndrome: A randomized trial","volume":"13","author":"M-J Kang","year":"2023","journal-title":"Sci Rep"},{"issue":"9","key":"pone.0340880.ref015","doi-asserted-by":"crossref","first-page":"3126","DOI":"10.3390\/jcm12093126","article-title":"The comparison between the composition of 100% autologous serum and 100% platelet-rich plasma eye drops and their impact on the treatment effectiveness of dry eye disease in primary sjogren syndrome","volume":"12","author":"D Wr\u00f3bel-Dudzi\u0144ska","year":"2023","journal-title":"J Clin Med"},{"issue":"7","key":"pone.0340880.ref016","article-title":"Use of autologous platelet-rich plasma in the treatment of dormant corneal ulcers","volume":"114","author":"JL Alio","year":"2007","journal-title":"Ophthalmology"},{"key":"pone.0340880.ref017","first-page":"2457620","article-title":"Autologous platelet-rich plasma eye drops for the treatment of post-LASIK chronic ocular surface syndrome","volume":"2017","author":"JL Alio","year":"2017","journal-title":"J Ophthalmol"},{"key":"pone.0340880.ref018","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.2147\/OPTH.S114890","article-title":"Causes and correction of dissatisfaction after implantation of presbyopia-correcting intraocular lenses","volume":"10","author":"A Gibbons","year":"2016","journal-title":"Clin Ophthalmol"},{"issue":"6","key":"pone.0340880.ref019","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/j.jcrs.2009.01.031","article-title":"Dissatisfaction after multifocal intraocular lens implantation","volume":"35","author":"MA Woodward","year":"2009","journal-title":"J Cataract Refract Surg"},{"key":"pone.0340880.ref020"},{"issue":"7","key":"pone.0340880.ref021","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1016\/j.jcrs.2004.04.031","article-title":"Optical quality analysis system; Instrument for objective clinical evaluation of ocular optical quality","volume":"30","author":"JL G\u00fcell","year":"2004","journal-title":"J Cataract Refract Surg"},{"issue":"1","key":"pone.0340880.ref022","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jcrs.2009.07.033","article-title":"Repeatability of measurements with a double-pass system","volume":"36","author":"A Saad","year":"2010","journal-title":"J Cataract Refract Surg"},{"issue":"4","key":"pone.0340880.ref023","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.ajo.2012.11.005","article-title":"Objective assessment of crystalline lens opacity level by measuring ocular light scattering with a double-pass system","volume":"155","author":"F Cabot","year":"2013","journal-title":"Am J Ophthalmol"},{"issue":"4","key":"pone.0340880.ref024","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1167\/iovs.05-1049","article-title":"Comparison of the retinal image quality with a Hartmann-Shack wavefront sensor and a double-pass instrument","volume":"47","author":"F D\u00edaz-Dout\u00f3n","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"2","key":"pone.0340880.ref025","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0016823","article-title":"An objective scatter index based on double-pass retinal images of a point source to classify cataracts","volume":"6","author":"P Artal","year":"2011","journal-title":"PLoS One"},{"issue":"5","key":"pone.0340880.ref026","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1097\/ICO.0b013e3182714425","article-title":"Assessment of tear film stability in dry eye with a newly developed keratograph","volume":"32","author":"J Hong","year":"2013","journal-title":"Cornea"},{"key":"pone.0340880.ref027","doi-asserted-by":"crossref","first-page":"8013621","DOI":"10.1155\/2016\/8013621","article-title":"Repeatability and reproducibility of noninvasive keratograph 5M measurements in patients with dry eye disease","volume":"2016","author":"L Tian","year":"2016","journal-title":"J Ophthalmol"},{"issue":"1","key":"pone.0340880.ref028","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1600-0587.2012.07348.x","article-title":"Collinearity: A review of methods to deal with it and a simulation study evaluating their performance","volume":"36","author":"CF Dormann","year":"2012","journal-title":"Ecography"},{"issue":"10","key":"pone.0340880.ref029","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/j.jcrs.2017.07.031","article-title":"Functional magnetic resonance imaging to assess neuroadaptation to multifocal intraocular lenses","volume":"43","author":"AM Rosa","year":"2017","journal-title":"J Cataract Refract Surg"},{"key":"pone.0340880.ref030","article-title":"Mechanisms of visual disturbance in dry eye","author":"S Koh","year":"2016","journal-title":"Cornea"},{"issue":"4","key":"pone.0340880.ref031","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1167\/tvst.7.4.5","article-title":"Impact of dry eye disease on vision quality: An optical quality analysis system study","volume":"7","author":"A Herbaut","year":"2018","journal-title":"Transl Vis Sci Technol"},{"key":"pone.0340880.ref032","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/978-3-030-21282-7_5","article-title":"Multifocal intraocular lenses: Neuroadaptation","volume-title":"Multifocal Intraocular Lenses","author":"JL Ali\u00f3","year":"2019"},{"issue":"5","key":"pone.0340880.ref033","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.jcrs.2010.11.032","article-title":"Dissatisfaction after implantation of multifocal intraocular lenses","volume":"37","author":"NE de Vries","year":"2011","journal-title":"J Cataract Refract Surg"},{"issue":"8","key":"pone.0340880.ref034","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0271267","article-title":"Identified risk factors for dry eye syndrome: A systematic review and meta-analysis","volume":"17","author":"L Qian","year":"2022","journal-title":"PLoS One"},{"issue":"7","key":"pone.0340880.ref035","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.jcrs.2016.03.039","article-title":"Optical quality and visual performance after cataract surgery with biaxial microincision intraocular lens implantation","volume":"42","author":"R Jim\u00e9nez","year":"2016","journal-title":"J Cataract Refract Surg"},{"issue":"11","key":"pone.0340880.ref036","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.18240\/ijo.2020.11.07","article-title":"Comparison of visual quality after implantation of A1-UV and SN60WF aspheric intraocular lens","volume":"13","author":"X Liao","year":"2020","journal-title":"Int J Ophthalmol"},{"issue":"4","key":"pone.0340880.ref037","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1097\/OPX.0000000000000190","article-title":"Double-pass system assessing the optical quality of pseudophakic eyes","volume":"91","author":"H Lee","year":"2014","journal-title":"Optom Vis Sci"},{"issue":"12","key":"pone.0340880.ref038","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1097\/OPX.0000000000001004","article-title":"Effect of decentration on the optical quality of two intraocular lenses","volume":"93","author":"C Ortiz","year":"2016","journal-title":"Optom Vis Sci"},{"issue":"2","key":"pone.0340880.ref039","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1136\/bjo.2006.099945","article-title":"Influence of tilt and decentration of scleral-sutured intraocular lens on ocular higher-order wavefront aberration","volume":"91","author":"T Oshika","year":"2007","journal-title":"Br J Ophthalmol"},{"issue":"1","key":"pone.0340880.ref040","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/cxo.13111","article-title":"Optical quality in patients with dry eye before and after treatment","volume":"104","author":"Y Gao","year":"2021","journal-title":"Clin Exp Optom"},{"issue":"11","key":"pone.0340880.ref041","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0078657","article-title":"Incidence and pattern of dry eye after cataract surgery","volume":"8","author":"N Kasetsuwan","year":"2013","journal-title":"PLoS One"},{"issue":"4","key":"pone.0340880.ref042","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/s10384-020-00744-1","article-title":"Effects of cataract surgery on symptoms and findings of dry eye in subjects with and without preexisting dry eye","volume":"64","author":"M Shimabukuro","year":"2020","journal-title":"Jpn J Ophthalmol"},{"key":"pone.0340880.ref043","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/978-1-4613-8896-8_12","article-title":"Light Scattering from Cornea and Corneal Transparency","volume-title":"Noninvasive Diagnostic Techniques in Ophthalmology","author":"RL McCally","year":"1990"},{"issue":"2","key":"pone.0340880.ref044","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s12551-009-0011-x","article-title":"Corneal collagen-its role in maintaining corneal shape and transparency","volume":"1","author":"KM Meek","year":"2009","journal-title":"Biophys Rev"},{"key":"pone.0340880.ref045","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1016\/j.jcrs.2016.08.015","article-title":"Double-pass technique and compensation-comparison method in eyes with cataract","volume":"42","author":"JA Martinez-Roda","year":"2016","journal-title":"J Cataract Refract Surg"},{"issue":"6","key":"pone.0340880.ref046","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1111\/cxo.12369","article-title":"Effects of aging on optical quality and visual function","volume":"99","author":"JA Mart\u00ednez-Roda","year":"2016","journal-title":"Clin Exp Optom"},{"key":"pone.0340880.ref047","doi-asserted-by":"crossref","first-page":"1075693","DOI":"10.3389\/fmed.2022.1075693","article-title":"Evaluation value of subjective visual quality examination on surgical indications of the early cataracts based on objective scatter index values","volume":"9","author":"Y Li","year":"2022","journal-title":"Front Med (Lausanne)"},{"issue":"2","key":"pone.0340880.ref048","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1097\/j.jcrs.0000000000000711","article-title":"Influence of anterior capsulorhexis shape, centration, size, and location on intraocular lens position: finite element model","volume":"48","author":"T Rossi","year":"2022","journal-title":"J Cataract Refract Surg"},{"issue":"4","key":"pone.0340880.ref049","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.pmr.2016.06.002","article-title":"Platelet-rich plasma","volume":"27","author":"PI-K Wu","year":"2016","journal-title":"Phys Med Rehabil Clin N Am"},{"issue":"6","key":"pone.0340880.ref050","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1002\/ksa.12682","article-title":"Indications and contraindications to platelet-rich plasma injections in musculoskeletal diseases in case of infectious, oncological and haematological comorbidities: A 2025 formal consensus from the GRIIP (International Research Group on Platelet Injections)","volume":"33","author":"F Eymard","year":"2025","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"issue":"4","key":"pone.0340880.ref051","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.jtos.2019.08.008","article-title":"The development and evaluation of the new Ocular Surface Disease Index-6","volume":"17","author":"H Pult","year":"2019","journal-title":"Ocul Surf"},{"issue":"11","key":"pone.0340880.ref052","doi-asserted-by":"crossref","first-page":"5537","DOI":"10.1167\/iovs.10-5341","article-title":"The development of an instrument to measure quality of vision: The Quality of Vision (QoV) questionnaire","volume":"51","author":"C McAlinden","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"}],"container-title":["PLOS One"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0340880","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T18:23:23Z","timestamp":1769538203000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0340880"}},"subtitle":[],"editor":[{"given":"Hyojin","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2026,1,27]]},"references-count":52,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1,27]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0340880","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,27]]}}}