{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T08:17:19Z","timestamp":1769588239055,"version":"3.49.0"},"reference-count":68,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Basic Research Projects of Liaoning Provincial Department of Education","award":["No. LJ222410164024"],"award-info":[{"award-number":["No. LJ222410164024"]}]},{"name":"Basic Research Projects of Liaoning Provincial Department of Education","award":["No. LI212510164032"],"award-info":[{"award-number":["No. LI212510164032"]}]},{"name":"Basic Research Projects of Liaoning Provincial Department of Education","award":["No. LJ222410164030"],"award-info":[{"award-number":["No. LJ222410164030"]}]},{"name":"Shenyang Young and Middle aged Science and Technology Talents Cultivation Special Project for Returning Overseas Youth","award":["No. RC230088"],"award-info":[{"award-number":["No. RC230088"]}]},{"name":"Doctoral Research Start-up Projects of the Natural Science Foundation of Liaoning Province","award":["No. 2024-BS-280"],"award-info":[{"award-number":["No. 2024-BS-280"]}]},{"name":"Liaoning Provincial Department of Scienceand Technology Program Project","award":["No.2024J2\/102600237"],"award-info":[{"award-number":["No.2024J2\/102600237"]}]},{"name":"Horizontal research project of Shenyang Sujiatun Central Hospital","award":["sykt2024008"],"award-info":[{"award-number":["sykt2024008"]}]},{"name":"Horizontal research project of Shenyang 242 Hospital","award":["sykt2023003"],"award-info":[{"award-number":["sykt2023003"]}]},{"name":"Shenyang Medical College Student Research Project","award":["No. 20249006"],"award-info":[{"award-number":["No. 20249006"]}]},{"name":"Liaoning Provincial Department of Scienceand Technology Program Project","award":["No. 2025JH2\/101900023"],"award-info":[{"award-number":["No. 2025JH2\/101900023"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:p>\n                    Recent studies have hinted at a link between periodontitis (PD) and influenza A (IA). Therefore, this study aims to identify key genes common to both diseases by studying\n                    <jats:italic>Porphyromonas gingivalis<\/jats:italic>\n                    (\n                    <jats:italic>P.gingivalis<\/jats:italic>\n                    ) and the H1N1 virus, the main pathogen of PD and IA, evaluating the promise of these genes as biomarkers, and providing future therapeutic strategies for both diseases. Our research employs a wide range of methods, including bioinformatics analysis, drug prediction and molecular docking. Ultimately, machine learning algorithms identified TNFAIP3 as a common key gene for PD and IA, and further identified five drugs: Vemurafenib, Metformin, Dexamethasone, Tretinoin and Imatinib with potential for combined treatment of PD and IA. Our study reveals the shared mechanism and immune profile of TNFAIP3 as a key gene in PD and IA, which lays a theoretical foundation for future targeted therapies based on the shared mechanism of the two diseases.\n                  <\/jats:p>","DOI":"10.1371\/journal.pone.0340882","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T18:29:28Z","timestamp":1769538568000},"page":"e0340882","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring the role of the key gene TNFAIP3 between periodontitis and influenza A through bioinformatic analysis and molecular docking"],"prefix":"10.1371","volume":"21","author":[{"given":"Mingxiang","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaxin","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiaozhi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiyun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinpeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luwei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fu","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yudong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9378-0939","authenticated-orcid":true,"given":"Kebin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2026,1,27]]},"reference":[{"issue":"1","key":"pone.0340882.ref001","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/nri3785","article-title":"Periodontitis: from microbial immune subversion to systemic inflammation","volume":"15","author":"G Hajishengallis","year":"2015","journal-title":"Nat Rev Immunol"},{"key":"pone.0340882.ref002","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.mam.2017.04.006","article-title":"Pro-resolving mediators in the regulation of periodontal disease","volume":"58","author":"TE Van Dyke","year":"2017","journal-title":"Mol Aspects Med"},{"issue":"5","key":"pone.0340882.ref003","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1177\/0022034517752675","article-title":"Dysbiotic Biofilms Deregulate the Periodontal Inflammatory Response","volume":"97","author":"ER Herrero","year":"2018","journal-title":"J Dent Res"},{"issue":"2","key":"pone.0340882.ref004","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1128\/AEM.02712-14","article-title":"Dysbiosis and alterations in predicted functions of the subgingival microbiome in chronic periodontitis","volume":"81","author":"ME Kirst","year":"2015","journal-title":"Appl Environ Microbiol"},{"issue":"2","key":"pone.0340882.ref005","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1128\/iai.42.2.659-667.1983","article-title":"Relationship between oxygen tension and subgingival bacterial flora in untreated human periodontal pockets","volume":"42","author":"WJ Loesche","year":"1983","journal-title":"Infect Immun"},{"key":"pone.0340882.ref006","doi-asserted-by":"crossref","DOI":"10.1590\/1678-7757-2019-0248","article-title":"Effect of periodontal treatment in patients with periodontitis and diabetes: systematic review and meta-analysis","volume":"28","author":"M Baeza","year":"2020","journal-title":"J Appl Oral Sci"},{"issue":"1","key":"pone.0340882.ref007","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.bj.2018.12.001","article-title":"Association between periodontal pathogens and systemic disease","volume":"42","author":"FQ Bui","year":"2019","journal-title":"Biomed J"},{"issue":"1","key":"pone.0340882.ref008","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1093\/epirev\/mxx006","article-title":"Periodontal disease, tooth loss, and cancer risk","volume":"39","author":"DS Michaud","year":"2017","journal-title":"Epidemiol Rev"},{"issue":"3","key":"pone.0340882.ref009","article-title":"Genetic exchange of fimbrial alleles exemplifies the adaptive virulence strategy of Porphyromonas gingivalis","volume":"9","author":"JE Kerr","year":"2014","journal-title":"PLoS One"},{"issue":"11","key":"pone.0340882.ref010","doi-asserted-by":"crossref","first-page":"3977","DOI":"10.1128\/JB.01691-06","article-title":"Construction of recombinant hemagglutinin derived from the gingipain-encoding gene of Porphyromonas gingivalis, identification of its target protein on erythrocytes, and inhibition of hemagglutination by an interdomain regional peptide","volume":"189","author":"E Sakai","year":"2007","journal-title":"J Bacteriol"},{"issue":"1","key":"pone.0340882.ref011","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1399-302X.2008.00467.x","article-title":"The host cytokine response to Porphyromonas gingivalis is modified by gingipains","volume":"24","author":"PG Stathopoulou","year":"2009","journal-title":"Oral Microbiol Immunol"},{"issue":"3","key":"pone.0340882.ref012","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1080\/21505594.2014.999567","article-title":"Porphyromonas gingivalis virulence factors involved in subversion of leukocytes and microbial dysbiosis","volume":"6","author":"C Zenobia","year":"2015","journal-title":"Virulence"},{"key":"pone.0340882.ref013","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.bpobgyn.2020.08.006","article-title":"Lessons learned from the A (H1N1) influenza pandemic","volume":"76","author":"N Vousden","year":"2021","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"issue":"5","key":"pone.0340882.ref014","first-page":"215","article-title":"MicroRNA-4485 ameliorates severe influenza pneumonia via inhibition of the STAT3\/PI3K\/AKT signaling pathway","volume":"20","author":"L Guo","year":"2020","journal-title":"Oncol Lett"},{"issue":"1","key":"pone.0340882.ref015","doi-asserted-by":"crossref","first-page":"3611","DOI":"10.1038\/s41467-025-58921-0","article-title":"TRAPT: a multi-stage fused deep learning framework for predicting transcriptional regulators based on large-scale epigenomic data","volume":"16","author":"G Zhang","year":"2025","journal-title":"Nat Commun"},{"key":"pone.0340882.ref016","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1186\/1471-2164-10-380","article-title":"The degree of microbiome complexity influences the epithelial response to infection","volume":"10","author":"JJ Mans","year":"2009","journal-title":"BMC Genomics"},{"issue":"6","key":"pone.0340882.ref017","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1111\/j.1462-5822.2005.00513.x","article-title":"Distinct transcriptional profiles characterize oral epithelium-microbiota interactions","volume":"7","author":"M Handfield","year":"2005","journal-title":"Cell Microbiol"},{"issue":"221","key":"pone.0340882.ref018","article-title":"Subgingival bacterial colonization profiles correlate with gingival tissue gene expression","volume":"9","author":"PN Papapanou","year":"2009","journal-title":"BMC Microbiology"},{"issue":"5","key":"pone.0340882.ref019","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1177\/0022034514527288","article-title":"Gingival tissue transcriptomes identify distinct periodontitis phenotypes","volume":"93","author":"M Kebschull","year":"2014","journal-title":"J Dent Res"},{"issue":"11","key":"pone.0340882.ref020","doi-asserted-by":"crossref","first-page":"6109","DOI":"10.1128\/JVI.06892-11","article-title":"Temporal- and strain-specific host microRNA molecular signatures associated with swine-origin H1N1 and avian-origin H7N7 influenza A virus infection","volume":"86","author":"E-K Loveday","year":"2012","journal-title":"J Virol"},{"issue":"11","key":"pone.0340882.ref021","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0078912","article-title":"Early host responses of seasonal and pandemic influenza A viruses in primary well-differentiated human lung epithelial cells","volume":"8","author":"RL Gerlach","year":"2013","journal-title":"PLoS One"},{"key":"pone.0340882.ref022","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.3389\/fimmu.2018.01193","article-title":"Influenza A Virus Facilitates Its Infectivity by Activating p53 to Inhibit the Expression of Interferon-Induced Transmembrane Proteins","volume":"9","author":"B Wang","year":"2018","journal-title":"Front Immunol"},{"issue":"6","key":"pone.0340882.ref023","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1093\/bioinformatics\/bts034","article-title":"The sva package for removing batch effects and other unwanted variation in high-throughput experiments","volume":"28","author":"JT Leek","year":"2012","journal-title":"Bioinformatics"},{"issue":"7","key":"pone.0340882.ref024","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkv007","article-title":"limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"ME Ritchie","year":"2015","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"pone.0340882.ref025","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/nar\/28.1.27","article-title":"KEGG: kyoto encyclopedia of genes and genomes","volume":"28","author":"M Kanehisa","year":"2000","journal-title":"Nucleic Acids Res"},{"key":"pone.0340882.ref026","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.sigpro.2016.03.001","article-title":"Generalized LASSO with under-determined regularization matrices","volume":"127","author":"J Duan","year":"2016","journal-title":"Signal Processing"},{"key":"pone.0340882.ref027","first-page":"795624","article-title":"SVM-RFE based feature selection and Taguchi parameters optimization for multiclass SVM classifier","volume":"2014","author":"M-L Huang","year":"2014","journal-title":"ScientificWorldJournal"},{"key":"pone.0340882.ref028","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/1471-2105-12-77","article-title":"pROC: an open-source package for R and S+ to analyze and compare ROC curves","volume":"12","author":"X Robin","year":"2011","journal-title":"BMC Bioinformatics"},{"issue":"5","key":"pone.0340882.ref029","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nmeth.3337","article-title":"Robust enumeration of cell subsets from tissue expression profiles","volume":"12","author":"AM Newman","year":"2015","journal-title":"Nat Methods"},{"issue":"7","key":"pone.0340882.ref030","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1093\/bioinformatics\/bty763","article-title":"Drug gene budger (DGB): an application for ranking drugs to modulate a specific gene based on transcriptomic signatures","volume":"35","author":"Z Wang","year":"2019","journal-title":"Bioinformatics"},{"issue":"6","key":"pone.0340882.ref031","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2017.10.049","article-title":"A next generation connectivity map: L1000 platform and the first 1,000,000 profiles","volume":"171","author":"A Subramanian","year":"2017","journal-title":"Cell"},{"issue":"5795","key":"pone.0340882.ref032","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1126\/science.1132939","article-title":"The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease","volume":"313","author":"J Lamb","year":"2006","journal-title":"Science"},{"key":"pone.0340882.ref033","doi-asserted-by":"crossref","first-page":"12846","DOI":"10.1038\/ncomms12846","article-title":"Extraction and analysis of signatures from the Gene Expression Omnibus by the crowd","volume":"7","author":"Z Wang","year":"2016","journal-title":"Nat Commun"},{"issue":"7","key":"pone.0340882.ref034","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1093\/bioinformatics\/btt055","article-title":"GROMACS 4.5: a high-throughput and highly parallel open source molecular simulation toolkit","volume":"29","author":"S Pronk","year":"2013","journal-title":"Bioinformatics"},{"issue":"9","key":"pone.0340882.ref035","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1038\/cdd.2017.89","article-title":"Pathogen-induced ubiquitin-editing enzyme A20 bifunctionally shuts off NF-\u03baB and caspase-8-dependent apoptotic cell death","volume":"24","author":"MCC Lim","year":"2017","journal-title":"Cell Death Differ"},{"issue":"5488","key":"pone.0340882.ref036","doi-asserted-by":"crossref","first-page":"2350","DOI":"10.1126\/science.289.5488.2350","article-title":"Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice","volume":"289","author":"EG Lee","year":"2000","journal-title":"Science"},{"issue":"7000","key":"pone.0340882.ref037","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1038\/nature02794","article-title":"De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling","volume":"430","author":"IE Wertz","year":"2004","journal-title":"Nature"},{"issue":"10","key":"pone.0340882.ref038","doi-asserted-by":"crossref","first-page":"7021","DOI":"10.4049\/jimmunol.179.10.7021","article-title":"Resolvin E1 regulates inflammation at the cellular and tissue level and restores tissue homeostasis in vivo","volume":"179","author":"H Hasturk","year":"2007","journal-title":"J Immunol"},{"issue":"1","key":"pone.0340882.ref039","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cmet.2010.12.008","article-title":"NF-\u03baB, inflammation, and metabolic disease","volume":"13","author":"RG Baker","year":"2011","journal-title":"Cell Metab"},{"issue":"2","key":"pone.0340882.ref040","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/S1471-4914(02)00010-2","article-title":"Influenza-virus-induced signaling cascades: targets for antiviral therapy?","volume":"9","author":"S Ludwig","year":"2003","journal-title":"Trends Mol Med"},{"key":"pone.0340882.ref041","doi-asserted-by":"crossref","first-page":"598444","DOI":"10.3389\/fimmu.2020.598444","article-title":"NF-\u03baB Pathway as a Potential Target for Treatment of Critical Stage COVID-19 Patients","volume":"11","author":"R Kircheis","year":"2020","journal-title":"Front Immunol"},{"issue":"2","key":"pone.0340882.ref042","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1093\/infdis\/jis340","article-title":"Critical role of natural killer cells in lung immunopathology during influenza infection in mice","volume":"206","author":"MF Abdul-Careem","year":"2012","journal-title":"J Infect Dis"},{"issue":"1","key":"pone.0340882.ref043","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.it.2013.10.005","article-title":"A20 in inflammation and autoimmunity","volume":"35","author":"L Catrysse","year":"2014","journal-title":"Trends Immunol"},{"issue":"9","key":"pone.0340882.ref044","doi-asserted-by":"crossref","first-page":"5763","DOI":"10.4049\/jimmunol.0900124","article-title":"Differential regulation of Foxp3 and IL-17 expression in CD4 T helper cells by IRAK-1","volume":"182","author":"U Maitra","year":"2009","journal-title":"J Immunol"},{"issue":"6","key":"pone.0340882.ref045","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/gene.2010.13","article-title":"Periodontitis and arthritis interaction in mice involves a shared hyper-inflammatory genotype and functional immunological interferences","volume":"11","author":"AP Trombone","year":"2010","journal-title":"Genes Immun"},{"issue":"3","key":"pone.0340882.ref046","article-title":"A20 inhibits osteoclastogenesis via TRAF6-dependent autophagy in human periodontal ligament cells under hypoxia","volume":"53","author":"K Yan","year":"2020","journal-title":"Cell Prolif"},{"issue":"5","key":"pone.0340882.ref047","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1111\/jcpe.13265","article-title":"Platelets as inflammatory mediators in a murine model of periodontitis","volume":"47","author":"Y Zhan","year":"2020","journal-title":"J Clin Periodontol"},{"issue":"8","key":"pone.0340882.ref048","doi-asserted-by":"crossref","first-page":"5301","DOI":"10.4049\/jimmunol.0900995","article-title":"Critical role of IL-17RA in immunopathology of influenza infection","volume":"183","author":"CR Crowe","year":"2009","journal-title":"J Immunol"},{"issue":"8","key":"pone.0340882.ref049","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1136\/thoraxjnl-2012-202404","article-title":"IL-17A inhibits airway reactivity induced by respiratory syncytial virus infection during allergic airway inflammation","volume":"68","author":"DC Newcomb","year":"2013","journal-title":"Thorax"},{"issue":"8","key":"pone.0340882.ref050","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1002\/art.27545","article-title":"A20 suppresses inflammatory responses and bone destruction in human fibroblast-like synoviocytes and in mice with collagen-induced arthritis","volume":"62","author":"Y-S Hah","year":"2010","journal-title":"Arthritis Rheum"},{"issue":"3","key":"pone.0340882.ref051","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.4049\/jimmunol.174.3.1507","article-title":"A20 is a negative regulator of IFN regulatory factor 3 signaling","volume":"174","author":"T Saitoh","year":"2005","journal-title":"J Immunol"},{"issue":"1","key":"pone.0340882.ref052","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005410","article-title":"A20 deficiency in lung epithelial cells protects against influenza A Virus infection","volume":"12","author":"J Maelfait","year":"2016","journal-title":"PLoS Pathog"},{"issue":"7","key":"pone.0340882.ref053","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1177\/0022034519847443","article-title":"IL-37- and IL-35\/IL-37-producing plasma cells in chronic periodontitis","volume":"98","author":"L Jing","year":"2019","journal-title":"J Dent Res"},{"issue":"11","key":"pone.0340882.ref054","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1111\/j.1600-051X.2009.01464.x","article-title":"Strain-dependent activation of the mouse immune response is correlated with Porphyromonas gingivalis-induced experimental periodontitis","volume":"36","author":"A Wilensky","year":"2009","journal-title":"J Clin Periodontol"},{"issue":"6","key":"pone.0340882.ref055","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1189\/jlb.1108710","article-title":"Immune dysregulation in severe influenza","volume":"85","author":"ML Heltzer","year":"2009","journal-title":"J Leukoc Biol"},{"issue":"8","key":"pone.0340882.ref056","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1128\/CVI.00194-13","article-title":"Influenza virus infection but not H1N1 influenza virus immunization is associated with changes in peripheral blood NK cell subset levels","volume":"20","author":"A Ju\u00e1rez-Reyes","year":"2013","journal-title":"Clin Vaccine Immunol"},{"issue":"1","key":"pone.0340882.ref057","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/prd.12107","article-title":"Gingival crevicular fluid as a source of biomarkers for periodontitis","volume":"70","author":"SP Barros","year":"2016","journal-title":"Periodontol 2000"},{"issue":"3","key":"pone.0340882.ref058","article-title":"The role of neutrophils during mild and severe influenza virus infections of mice","volume":"6","author":"MD Tate","year":"2011","journal-title":"PLoS One"},{"issue":"11","key":"pone.0340882.ref059","doi-asserted-by":"crossref","first-page":"7441","DOI":"10.4049\/jimmunol.0902497","article-title":"Neutrophils ameliorate lung injury and the development of severe disease during influenza infection","volume":"183","author":"MD Tate","year":"2009","journal-title":"J Immunol"},{"issue":"26","key":"pone.0340882.ref060","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.1056\/NEJMoa1103782","article-title":"Improved survival with vemurafenib in melanoma with BRAF V600E mutation","volume":"364","author":"PB Chapman","year":"2011","journal-title":"N Engl J Med"},{"issue":"13","key":"pone.0340882.ref061","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1056\/NEJM199803263381303","article-title":"Efficacy and metabolic effects of metformin and troglitazone in type II diabetes mellitus","volume":"338","author":"SE Inzucchi","year":"1998","journal-title":"N Engl J Med"},{"issue":"7556","key":"pone.0340882.ref062","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/522265a","article-title":"Anti-ageing pill pushed as bona fide drug","volume":"522","author":"E Check Hayden","year":"2015","journal-title":"Nature"},{"issue":"7","key":"pone.0340882.ref063","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/j.metabol.2013.01.014","article-title":"Metformin and sulfonylureas in relation to cancer risk in type II diabetes patients: a meta-analysis using primary data of published studies","volume":"62","author":"B Thakkar","year":"2013","journal-title":"Metabolism"},{"key":"pone.0340882.ref064","doi-asserted-by":"crossref","first-page":"246","DOI":"10.22203\/eCM.v038a17","article-title":"Dexamethasone: chondroprotective corticosteroid or catabolic killer?","volume":"38","author":"R Black","year":"2019","journal-title":"Eur Cell Mater"},{"issue":"6","key":"pone.0340882.ref065","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/s00403-021-02256-5","article-title":"Efficacy assessments of tretinoin-loaded nano lipid carriers in acne vulgaris: a double blind, split-face randomized clinical study","volume":"314","author":"A Samadi","year":"2022","journal-title":"Arch Dermatol Res"},{"issue":"6","key":"pone.0340882.ref066","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1111\/jre.12351","article-title":"Influence of retinoic acid on human gingival epithelial barriers","volume":"51","author":"S Groeger","year":"2016","journal-title":"J Periodontal Res"},{"key":"pone.0340882.ref067","doi-asserted-by":"crossref","first-page":"108757","DOI":"10.1016\/j.intimp.2022.108757","article-title":"All-trans retinoic acid inhibits the osteogenesis of periodontal ligament stem cells by promoting IL-1\u03b2 production via NF-\u03baB signaling","volume":"108","author":"L Guo","year":"2022","journal-title":"Int Immunopharmacol"},{"issue":"12","key":"pone.0340882.ref068","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/s41419-023-06300-2","article-title":"Imatinib induces ferroptosis in gastrointestinal stromal tumors by promoting STUB1-mediated GPX4 ubiquitination","volume":"14","author":"X Sun","year":"2023","journal-title":"Cell Death Dis"}],"container-title":["PLOS One"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0340882","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T18:29:40Z","timestamp":1769538580000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0340882"}},"subtitle":[],"editor":[{"given":"Courtney G.","family":"Montgomery","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2026,1,27]]},"references-count":68,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1,27]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0340882","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,27]]}}}