{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T19:30:48Z","timestamp":1771875048054,"version":"3.50.1"},"reference-count":45,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T00:00:00Z","timestamp":1771804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Capital\u00e2\u20ac\u2122s Funds for Health Improvement and Research"},{"name":"Training Program for the High-Level Public Health Technical Talents Development Project","award":["Academic Leaders-02-15"],"award-info":[{"award-number":["Academic Leaders-02-15"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Human Immunodeficiency Virus (HIV) and tuberculosis (TB) co-infection poses a significant challenge to public health systems due to its complex clinical management and high mortality. This study aimed to reveal the specific mechanisms through which knowledge influences practice in HIV\/TB co-infection management among healthcare providers (HCPs) using structural equation modeling (SEM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>An exploratory cross-sectional study using convenience sampling was conducted from May to June 2025 involving healthcare providers (HCPs) across various medical institutions in Beijing, which included university-affiliated tertiary hospitals, specialized hospitals, and community health centers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 565 valid questionnaires were collected, with 364 (64.42%) completed by medical doctors. The knowledge, attitude, and practice scores were 18.51\u2009\u00b1\u20097.75 (possible range: 0\u201330), 43.64\u2009\u00b1\u20095.51 (possible range: 10\u201350), and 30.75\u2009\u00b1\u20097.44 (possible range: 8\u201340), respectively. Spearman correlation analysis revealed significant positive correlations between knowledge and attitude (r\u2009=\u20090.500, P\u2009&lt;\u20090.001), between attitude and practice (r\u2009=\u20090.584, P\u2009&lt;\u20090.001) and between knowledge and practice (r\u2009=\u20090.592, P\u2009&lt;\u20090.001). SEM analysis indicated that knowledge had a direct influence on both attitudes (\u03b2\u2009=\u20090.458, P\u2009=\u20090.002) and practices (\u03b2\u2009=\u20090.491, P\u2009=\u20090.011), while attitudes influenced practices (\u03b2\u2009=\u20090.272, P\u2009=\u20090.008). Furthermore, knowledge indirectly affected practices through attitudes (\u03b2\u2009=\u20090.124, P\u2009=\u20090.005).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In our sample, respondents demonstrated limited knowledge, generally positive attitudes, and moderately adequate practices regarding HIV and TB co-infection. These preliminary findings suggest that targeted educational interventions designed to enhance knowledge may effectively improve both attitudes and practical behaviors, though more rigorous research is needed to confirm these relationships.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0341132","type":"journal-article","created":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T18:23:27Z","timestamp":1771871007000},"page":"e0341132","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Knowledge, attitudes, and practices of healthcare providers in Beijing regarding human immunodeficiency virus and tuberculosis co-infection: A multicenter cross-sectional study"],"prefix":"10.1371","volume":"21","author":[{"given":"Yuwei","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinghe","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yufei","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9281-0052","authenticated-orcid":true,"given":"Xiaoyou","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2026,2,23]]},"reference":[{"issue":"1","key":"pone.0341132.ref001","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1186\/s12879-023-08505-4","article-title":"The metabolic consequences of HIV\/TB co-infection","volume":"23","author":"C Herbert","year":"2023","journal-title":"BMC Infect Dis"},{"key":"pone.0341132.ref002","volume-title":"Global tuberculosis report 2021: supplementary material","author":"Organization WH","year":"2022"},{"key":"pone.0341132.ref003","doi-asserted-by":"crossref","first-page":"1475498","DOI":"10.3389\/frph.2024.1475498","article-title":"Global, regional, and national burden of HIV and tuberculosis and predictions by Bayesian age-period-cohort analysis: a systematic analysis for the global burden of disease study 2021","volume":"6","author":"X Tian","year":"2024","journal-title":"Front Reprod Health"},{"issue":"7","key":"pone.0341132.ref004","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a017871","article-title":"Tuberculosis and HIV Coinfection","volume":"5","author":"J Bruchfeld","year":"2015","journal-title":"Cold Spring Harb Perspect Med"},{"key":"pone.0341132.ref005","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.ejmech.2018.03.020","article-title":"Drug discovery in tuberculosis. 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