{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T19:22:34Z","timestamp":1771615354562,"version":"3.50.1"},"reference-count":31,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:00:00Z","timestamp":1771545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Tianjin Key Medical Discipline Construction Project","award":["TJYXZDXK-3-007B"],"award-info":[{"award-number":["TJYXZDXK-3-007B"]}]},{"name":"National Natural Science Foundation of China - General Projects","award":["82570828"],"award-info":[{"award-number":["82570828"]}]},{"name":"National Key Research and Development Program of China","award":["2024YFC3607400"],"award-info":[{"award-number":["2024YFC3607400"]}]},{"name":"Tianjin Health Research Project","award":["TJWJ2025RC005"],"award-info":[{"award-number":["TJWJ2025RC005"]}]},{"name":"Tianjin Institute of Urology talent funding program","award":["MYSRC2024"],"award-info":[{"award-number":["MYSRC2024"]}]},{"name":"Key Project of Natural Science Foundation of Tianjin","award":["22JCZDJC00590"],"award-info":[{"award-number":["22JCZDJC00590"]}]},{"name":"Tianjin Key Medical Discipline(Specialty)Construct Project","award":["TJYXZDXK-032A"],"award-info":[{"award-number":["TJYXZDXK-032A"]}]},{"name":"Tianjin Key Cultivation Medical Discipline Construction Project","award":["TJYXZDXK-3-018C"],"award-info":[{"award-number":["TJYXZDXK-3-018C"]}]},{"name":"First Level Leading Talent Project of 123 Climbing Plan for Clinical Talents of Tianjin Medical University"},{"name":"Tianjin Medical Talents project,the second batch of high-level talents selection project in health industry in Tianjin","award":["TJSJMYXYC-D2-014"],"award-info":[{"award-number":["TJSJMYXYC-D2-014"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background and objectives<\/jats:title>\n                    <jats:p>The relationship between increased inflammatory diet patterns and chronic kidney disease (CKD) remains unknown and has not been investigated in large cohorts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 154,070 adults registered in UKB database were enrolled and followed, free of CKD and eGFR\u2009&gt;\u200990 mL\/min\/1.73 m2 at baseline. The energy-adjusted dietary inflammatory index (E-DII) was evaluated using the 24-h recall diet. Cox proportional hazards regression models were used, adjusting for confounders such as demographic indicators, socioeconomic status, and lifestyle factors. Additionally, a subgroup analysis was conducted to investigate the relationship with incident CKD. The nonlinear relationship between E-DII and CKD risk was analyzed using a restricted cubic spline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>During a median follow-up of 11.4 years, 3402 (2.21%) cases occurred. After adjustment for all potential confounders, a higher E-DII was associated with an increased risk of incident CKD (HR for 1 unit increment: 1.05 (1.00\u20131.10), p\u2009=\u20090.034). According to the result of the restricted cubic spline, when E-DII\u2009&gt;\u20091.857, the risk of early-stage CKD would increase significantly.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A higher pro-inflammatory diet was associated with an increased risk of early-stage CKD in the fully adjusted model. An anti-inflammatory diet may serve as a potential preventive strategy for early-stage CKD, although causal inference cannot be established from this observational study.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0341502","type":"journal-article","created":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T18:36:16Z","timestamp":1771612576000},"page":"e0341502","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dietary inflammatory index in relation to incident CKD: A prospective study of UK Biobank 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