{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T06:43:09Z","timestamp":1770100989143,"version":"3.49.0"},"reference-count":55,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study analyzed the temporal trends in the age- and gender-specific disease burden of gastroesophageal reflux disease (GERD) in China from 1990 to 2021, comparing its incidence, prevalence, and disability-adjusted life years (DALYs) with global estimates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data were extracted from the Global Burden of Disease (GBD) database 1990\u20132021. The Joinpoint regression model was used to quantify trends via annual average percentage change (AAPC) and 95% confidence intervals. Multidimensional comparisons were conducted by age, gender, and time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>From 1990 to 2021, China exhibited declining trends in age-standardized incidence, prevalence, and DALYs rates for GERD, in contrast to increasing trends globally. Disease burden was higher among females and increased with age, with the middle-aged and elderly experiencing the greatest rise. Projections indicate a continued increase in GERD burden in China by 2040.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Despite recent declines, GERD remains a significant public health challenge in China due to its large population and rapid aging. Targeted prevention and intervention strategies are urgently needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0341619","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T18:31:10Z","timestamp":1770057070000},"page":"e0341619","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Trends in the burden of gastroesophageal reflux disease in China and Global from 1990 to 2021 and predictive analysis for 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