{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T19:10:39Z","timestamp":1772565039954,"version":"3.50.1"},"reference-count":26,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:00:00Z","timestamp":1772496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"DFG Deutsche Forschungsgemeinschaft","award":["471863651"],"award-info":[{"award-number":["471863651"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Childhood stroke is a rare but potentially life-threatening event that can occur at any age. It requires prompt diagnosis and appropriate treatment, and, in view of the frequent neurological and neurocognitive sequelae, long-term care in a multidisciplinary and multiprofessional setting. The management of stroke in children, which differs in many aspects from stroke in adults, often relies on local expert opinions and retrospectively collected data rather than high-quality evidence from prospective randomized controlled clinical trials, especially in the acute phase.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>\n                      The\n                      <jats:bold>Pediatric Registry for Stroke as a Multidisciplinary Approach to healthcare research (PRiSMA)<\/jats:bold>\n                      study aims to systematically collect longitudinal prospective observational data across the acute and long-term phases to optimise diagnosis, personalised acute therapy, neurorehabilitation, and prevention of recurrent stroke. The data will inform development of further hypothesis-driven studies of childhood stroke in national and international networks.\n                    <\/jats:p>\n                    <jats:p>Furthermore, PRiSMA will facilitate case-specific collaboration within the registry network, allowing treating clinicians to consult experienced colleagues on complex cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In PRiSMA all children and adolescents (&gt;28 days of life,\u2009\u2264\u200918years) with arterial ischemic stroke (AIS) or hemorrhagic stroke (HS) are eligible for recruitment. The nationwide multicenter, systematic data collection is performed in the acute and chronic phases, extracted from patient medical records supplemented by direct registry-specific medical history provided by caregivers. In addition, a questionnaire-based data on quality of life and behaviour will be collected. International collaborations are established across Germany, Austria and the Netherlands.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Status<\/jats:title>\n                    <jats:p>Currently, 16 centres in Germany and 1 centre in Austria have commenced recruitment. 30 patients are currently (17 Nov 25) enrolled after arterial ischaemic stroke and 1 after haemorrhagic stroke.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0341646","type":"journal-article","created":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T18:21:32Z","timestamp":1772562092000},"page":"e0341646","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Protocol for the establishment of the Pediatric Registry for Stroke as a Multidisciplinary Approach to healthcare research (PRiSMA) study"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4490-5357","authenticated-orcid":true,"given":"Lucia","family":"Gerstl","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria","family":"Lieft\u00fcchter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Jung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Heinen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dewi","family":"Bakker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steffen","family":"Berweck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Dzietko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Liebig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Olivieri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rainer","family":"Seidl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald","family":"Str\u00e4ter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clara","family":"Haacke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Lippert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Glatter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jakub","family":"Fusiak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Christ","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Lauseker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"PRiSMA study group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2026,3,3]]},"reference":[{"issue":"12","key":"pone.0341646.ref001","doi-asserted-by":"crossref","first-page":"2929","DOI":"10.1007\/s00415-019-09508-5","article-title":"Arterial ischemic stroke in infants, children, and adolescents: results of a Germany-wide surveillance study 2015-2017","volume":"266","author":"L Gerstl","year":"2019","journal-title":"J Neurol"},{"issue":"2","key":"pone.0341646.ref002","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1080\/17518423.2016.1247923","article-title":"Long-term motor, functional, and academic outcome following childhood ischemic and hemorrhagic stroke: A large rehabilitation center-based retrospective study","volume":"21","author":"E Yvon","year":"2018","journal-title":"Dev Neurorehabil"},{"key":"pone.0341646.ref003","doi-asserted-by":"crossref","first-page":"100998","DOI":"10.1016\/j.spen.2022.100998","article-title":"Rehabilitation in Pediatric Stroke: Cognition and Behavior","volume":"44","author":"C Mrakotsky","year":"2022","journal-title":"Semin Pediatr Neurol"},{"issue":"11","key":"pone.0341646.ref004","doi-asserted-by":"crossref","first-page":"2622","DOI":"10.1161\/STROKEAHA.124.046518","article-title":"Long-Term Neurologic Outcomes in Pediatric Arterial Ischemic Stroke: The Impact of Age and Lesion Location","volume":"55","author":"J Singh","year":"2024","journal-title":"Stroke"},{"issue":"5","key":"pone.0341646.ref005","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1161\/STROKEAHA.120.032955","article-title":"Social Cognitive Dysfunction Following Pediatric Arterial Ischemic Stroke: Evidence From a Prospective Cohort Study","volume":"52","author":"NP Ryan","year":"2021","journal-title":"Stroke"},{"issue":"1","key":"pone.0341646.ref006","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1002\/ana.22224","article-title":"Arterial ischemic stroke risk factors: the International Pediatric Stroke Study","volume":"69","author":"MT Mackay","year":"2011","journal-title":"Ann Neurol"},{"issue":"2","key":"pone.0341646.ref007","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1055\/s-2005-837658","article-title":"The first three years of the Swiss Neuropaediatric Stroke Registry (SNPSR): a population-based study of incidence, symptoms and risk factors","volume":"36","author":"M Steinlin","year":"2005","journal-title":"Neuropediatrics"},{"issue":"1","key":"pone.0341646.ref008","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/s41572-022-00337-x","article-title":"Childhood stroke","volume":"8","author":"PB Sporns","year":"2022","journal-title":"Nat Rev Dis Primers"},{"issue":"7","key":"pone.0341646.ref009","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1111\/dmcn.13393","article-title":"Planning interventional trials in childhood arterial ischaemic stroke using a Delphi consensus process","volume":"59","author":"M Steinlin","year":"2017","journal-title":"Dev Med Child Neurol"},{"issue":"3","key":"pone.0341646.ref010","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1161\/STROKEAHA.114.008210","article-title":"Thrombolysis in pediatric stroke study","volume":"46","author":"MJ Rivkin","year":"2015","journal-title":"Stroke"},{"issue":"2","key":"pone.0341646.ref011","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1212\/01.WNL.0000078894.79866.95","article-title":"Risk of stroke in children: ethnic and gender disparities","volume":"61","author":"HJ Fullerton","year":"2003","journal-title":"Neurology"},{"issue":"1","key":"pone.0341646.ref012","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S1474-4422(13)70290-4","article-title":"Childhood arterial ischaemic stroke incidence, presenting features, and risk factors: a prospective population-based study","volume":"13","author":"AA Mallick","year":"2014","journal-title":"Lancet Neurol"},{"key":"pone.0341646.ref013","author":"DS Bundesamt","year":"2024"},{"key":"pone.0341646.ref014","first-page":"125","article-title":"Psychometric properties of the KINDL-R questionnaire: results of the BELLA study","author":"BELLA Study Group","year":"2008","journal-title":"Eur Child Adolesc Psychiatry"},{"issue":"5","key":"pone.0341646.ref015","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1023\/A:1008853819715","article-title":"Assessing health-related quality of life in chronically ill children with the German KINDL: first psychometric and content analytical results","volume":"7","author":"U Ravens-Sieberer","year":"1998","journal-title":"Qual Life Res"},{"key":"pone.0341646.ref016","first-page":"653","article-title":"News from the KINDL-Questionnaire \u2013 A new version for adolescents","volume":"7","author":"U Ravens-Sieberer","year":"1998","journal-title":"Quality of Life Research"},{"key":"pone.0341646.ref017","volume-title":"CBCL\/6-18R, TRF\/6-18R, YSR\/11-18R. Deutsche Schulalter-Formen der Child Behaviour Checklist von Thomas M. Achenbach","author":"M D\u00f6pfner","year":"2014"},{"issue":"5","key":"pone.0341646.ref018","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1212\/WNL.0b013e3181cbcd48","article-title":"The 5-year direct medical cost of neonatal and childhood stroke in a population-based cohort","volume":"74","author":"MA Gardner","year":"2010","journal-title":"Neurology"},{"issue":"2","key":"pone.0341646.ref019","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.ejpn.2014.12.006","article-title":"Outcomes following childhood arterial ischaemic stroke: a Delphi Consensus on what parents want from future research","volume":"19","author":"H Edwards","year":"2015","journal-title":"Eur J Paediatr Neurol"},{"issue":"12","key":"pone.0341646.ref020","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/S2352-4642(24)00233-5","article-title":"Endovascular thrombectomy for childhood stroke (Save ChildS Pro): an international, multicentre, prospective registry study","volume":"8","author":"PB Sporns","year":"2024","journal-title":"Lancet Child Adolesc Health"},{"issue":"1","key":"pone.0341646.ref021","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1001\/jamaneurol.2019.3403","article-title":"Feasibility, Safety, and Outcome of Endovascular Recanalization in Childhood Stroke: The Save ChildS Study","volume":"77","author":"PB Sporns","year":"2020","journal-title":"JAMA Neurol"},{"issue":"6","key":"pone.0341646.ref022","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1002\/ana.25242","article-title":"Feasibility, safety, and outcome of recanalization treatment in childhood stroke","volume":"83","author":"S Bigi","year":"2018","journal-title":"Ann Neurol"},{"key":"pone.0341646.ref023","volume-title":"Methodological manual on territorial typologies","author":"Eurostat","year":"2019"},{"issue":"6","key":"pone.0341646.ref024","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1227\/01.NEU.0000143030.85589.E6","article-title":"Spinal cord injury without radiographic abnormality in children, 2 decades later","volume":"55","author":"D Pang","year":"2004","journal-title":"Neurosurgery"},{"issue":"4","key":"pone.0341646.ref025","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.pediatrneurol.2007.01.006","article-title":"Ischemic spinal cord infarction in children without vertebral fracture","volume":"36","author":"JR Nance","year":"2007","journal-title":"Pediatr Neurol"},{"issue":"2","key":"pone.0341646.ref026","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.ejpn.2012.09.002","article-title":"Non-traumatic spinal cord ischaemia in childhood - clinical manifestation, neuroimaging and outcome","volume":"17","author":"S Stettler","year":"2013","journal-title":"Eur J Paediatr Neurol"}],"container-title":["PLOS One"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0341646","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T18:21:35Z","timestamp":1772562095000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0341646"}},"subtitle":[],"editor":[{"given":"Jennifer","family":"Tucker","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2026,3,3]]},"references-count":26,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,3,3]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0341646","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,3]]}}}