{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T03:18:57Z","timestamp":1792293537580,"version":"4.4.0"},"reference-count":64,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:00:00Z","timestamp":1770336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"U.S. Department of State through BUET","award":["Under the project \u201cAssessing Health Impacts of Urban Flooding under Changing Climate: A Case Study in Dhaka City\u201d"],"award-info":[{"award-number":["Under the project \u201cAssessing Health Impacts of Urban Flooding under Changing Climate: A Case Study in Dhaka City\u201d"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:p>\n                    The World Health Organization has recommended the development of new antimicrobials against\n                    <jats:italic>Acinetobacter baumannii<\/jats:italic>\n                    , one of the six highly significant pathogens. In this study, 28 wastewater samples were collected from the Goranchatbari sub-catchment area in Dhaka city over several periods. The samples were characterized for the presence of\n                    <jats:italic>Acinetobacter<\/jats:italic>\n                    spp. The isolates showing cream, opaque colonies on CHROMagar\n                    <jats:sup>TM<\/jats:sup>\n                    ESBL plates were considered positive for ESBL production. They were further characterized for major antibiotic resistance and pathogenic genes, biofilm production and antibiotic susceptibility testing. Furthermore, the isolates were phylogenetically clustered based on their Enterobacterial Repetitive Intergenic Consensus (ERIC) profiles and correlation matrix analysis was performed. Out of 28 samples, 27 were positive for\n                    <jats:italic>Acinetobacter<\/jats:italic>\n                    spp. and a total of 106\/249 (42.6%) sample representative isolates were positive for ESBL production. Out of these 106 isolates, 97 (91.5%) were genotypically confirmed to belong to the\n                    <jats:italic>Acinetobacter<\/jats:italic>\n                    spp\n                    <jats:italic>.<\/jats:italic>\n                    and of which, 72 (74.2%) were genotypically confirmed as\n                    <jats:italic>Acinetobacter baumannii<\/jats:italic>\n                    . Among the distribution of \u03b2-lactamase genes,\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>TEM<\/jats:sub>\n                    was the most prevalent being present in 40\/72 (55.6%) isolates, followed by\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>SHV<\/jats:sub>\n                    in 3\/72 (4.2%) isolates. With respect to the pathogenic genes,\n                    <jats:italic>pgaB<\/jats:italic>\n                    and\n                    <jats:italic>bfmS<\/jats:italic>\n                    were the most prevalent being present in 80.6% and 69.4% of the isolates, respectively. The antibiotic susceptibility testing revealed a diverse range of resistance patterns with high levels of intermediate resistance being observed for cefotaxime and ceftriaxone. The biofilm formation screening revealed that 48.6% and 44.4% of isolates formed strong biofilms at 37\u00b0C and 25\u00b0C, respectively. The phylogenetic clustering of the\n                    <jats:italic>A. baumannii<\/jats:italic>\n                    isolates resulted in the formation of 10 clusters at 60% similarity index, and the correlation matrix helped reveal important associations between genotypic and phenotypic traits. These results demonstrate the continued prevalence of\n                    <jats:italic>A. baumannii<\/jats:italic>\n                    within these environmental reservoirs and its ability to persist despite seasonal variations, prioritizing changes in environmental health policies that aim to reduce the widespread prevalence of these pathogens.\n                  <\/jats:p>","DOI":"10.1371\/journal.pone.0341652","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T18:26:13Z","timestamp":1770402373000},"page":"e0341652","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["Isolation, molecular profiling, and antimicrobial sensitivity patterns of ESBL producing Acinetobacter baumannii in wastewater discharges from Goranchatbari sub-catchment area in Dhaka"],"prefix":"10.1371","volume":"21","author":[{"given":"Amanta","family":"Rahman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayeema","family":"Haque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Tanveer","family":"Hussain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9680-4921","authenticated-orcid":true,"given":"Md. Sakib","family":"Hossain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed Ishtiaque Amin","family":"Chowdhury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3022-6854","authenticated-orcid":true,"given":"Md. Foysal","family":"Abedin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tahani","family":"Tabassum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Hajbiur","family":"Rahman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Atique","family":"Ul Alam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Rafiqul","family":"Islam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iftekhar Bin","family":"Naser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Shafiqul","family":"Islam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3278-0622","authenticated-orcid":true,"given":"Zahid Hayat","family":"Mahmud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,2,6]]},"reference":[{"key":"pone.0341652.ref001","volume-title":"Antimicrobial resistance","author":"World Health Organization","year":"2023"},{"key":"pone.0341652.ref002","article-title":"Covid-19: Antimicrobial resistance rose dangerously in US during pandemic, CDC says","author":"JH Tanne","year":"2022","journal-title":"British Medical Journal Publishing Group"},{"key":"pone.0341652.ref003","article-title":"Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis","author":"CJL 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