{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T19:13:51Z","timestamp":1772046831596,"version":"3.50.1"},"reference-count":45,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:00:00Z","timestamp":1771977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Clozapine-induced cardiac inflammation (CICI) can have serious consequences for people with psychosis and can be fatal if not detected in a timely manner. The best available methods of investigation for CICI are resource-intensive, whereas clinical practice often utilises cheaper and more practical methods of detection such as history, examination, and blood tests. Heart rate monitoring is commonly used as an early-warning sign in detecting potential CICI. Previous studies have found that, although this has a high sensitivity, it has poor specificity. As far as we are aware, no systematic review has investigated the role of tachycardia as a detection tool for CICI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>Systematic diagnostic test accuracy review of the available literature will be used to assess the effectiveness of tachycardia as an early-warning sign for CICI. We will search eight electronic databases and grey literature using a comprehensive and systematic approach. Grey literature sources will include conference proceedings and professional guidance documents identified through expert consultations. Retrieved articles will be critically appraised, synthesised, and meta-analysed, where data permit.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>This systematic review will use data from existing studies, hence no ethical approvals are required. Findings will be disseminated to academic colleagues through a peer-reviewed publication and relevant academic meetings, and to clinicians through distribution to local and national clinical networks.<\/jats:p>\n                    <jats:p>\n                      PROSPERO registration ID:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/CRD42025650379\" xlink:type=\"simple\">CRD42025650379<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0341729","type":"journal-article","created":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T18:34:13Z","timestamp":1772044453000},"page":"e0341729","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Reliability of tachycardia as an early warning sign in acute clozapine-induced cardiac inflammation: Protocol for a systematic review"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8664-8825","authenticated-orcid":true,"given":"James Richard","family":"O\u2019Neill","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prakruti Babu Narendra","family":"Prasad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Croft","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Manton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalie","family":"King","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2417-0202","authenticated-orcid":true,"given":"Daniel","family":"Romeu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2026,2,25]]},"reference":[{"issue":"2","key":"pone.0341729.ref001","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1111\/acps.13328","article-title":"Monitoring for myocarditis during treatment initiation with 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A proposed typology and guidance for systematic reviewers in the medical and health sciences","volume":"18","author":"Z Munn","year":"2018","journal-title":"BMC Med Res Methodol"},{"key":"pone.0341729.ref037","author":"JBI","year":"2020"},{"key":"pone.0341729.ref038","volume-title":"The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses","author":"GA Wells","year":"2021"},{"key":"pone.0341729.ref039","unstructured":"Microsoft. Microsoft Excel for Microsoft 365 MSO. 2025."},{"key":"pone.0341729.ref040","volume-title":"Stata, version 18","author":"StataCorp","year":"2024"},{"key":"pone.0341729.ref041","author":"National Institute for Health and Care Research","year":"2021"},{"key":"pone.0341729.ref042","doi-asserted-by":"crossref","first-page":"60","DOI":"10.12703\/P7-60","article-title":"Management of tachycardia","volume":"7","author":"R Gopinathannair","year":"2015","journal-title":"F1000Prime Rep"},{"issue":"1","key":"pone.0341729.ref043","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1136\/eb-2012-100645","article-title":"Principles for high-quality, high-value testing","volume":"18","author":"M Power","year":"2013","journal-title":"Evid Based Med"},{"issue":"1","key":"pone.0341729.ref044","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1017\/S1461145706006961","article-title":"Late occurrence of clozapine-associated polyserositis","volume":"10","author":"H Waller","year":"2007","journal-title":"Int J Neuropsychopharmacol"},{"key":"pone.0341729.ref045","unstructured":"Macdonald O. Community initiation protocol for clozapine. 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