{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T07:31:41Z","timestamp":1770276701966,"version":"3.49.0"},"reference-count":104,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN-2025-03958"],"award-info":[{"award-number":["RGPIN-2025-03958"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:p>\n                    The systems regulating blood pressure and calcium-magnesium (Ca\n                    <jats:sup>2+<\/jats:sup>\n                    -Mg\n                    <jats:sup>2+<\/jats:sup>\n                    ) homeostasis are increasingly recognized to have clinically relevant interactions, where alterations in one can lead to significant changes in the other. In this study, we developed a computational model integrating blood pressure regulation and Ca\n                    <jats:sup>2+<\/jats:sup>\n                    -Mg\n                    <jats:sup>2+<\/jats:sup>\n                    homeostasis in a male rat. We simulated various conditions, including hypertension, Ca\n                    <jats:sup>2+<\/jats:sup>\n                    , Mg\n                    <jats:sup>2+<\/jats:sup>\n                    , and vitamin D\n                    <jats:sub>3<\/jats:sub>\n                    deficiencies, and primary hyperparathyroidism. Simulations of hypertension, induced by various stimuli like increased renin or aldosterone secretion, demonstrated significant effects on parathyroid hormone (PTH), calcitriol, renal Ca\n                    <jats:sup>2+<\/jats:sup>\n                    \/Mg\n                    <jats:sup>2+<\/jats:sup>\n                    handling, and bone resorption. Dietary Ca\n                    <jats:sup>2+<\/jats:sup>\n                    , Mg\n                    <jats:sup>2+<\/jats:sup>\n                    , and vitamin D\n                    <jats:sub>3<\/jats:sub>\n                    deficiencies was predicted to elevate mean arterial pressure, with Mg\n                    <jats:sup>2+<\/jats:sup>\n                    deficiency having a stronger effect. Furthermore, the model predicted that primary hyperparathyroidism elevates PTH, Ca\n                    <jats:sup>2+<\/jats:sup>\n                    , and calcitriol, leading to increased mean arterial pressure and bone loss. Overall, this model provides valuable insights into the mechanistic links between blood pressure regulation and Ca\n                    <jats:sup>2+<\/jats:sup>\n                    -Mg\n                    <jats:sup>2+<\/jats:sup>\n                    homeostasis, offering insights into clinical conditions like hypertension and hyperparathyroidism.\n                  <\/jats:p>","DOI":"10.1371\/journal.pone.0341800","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T18:38:38Z","timestamp":1770230318000},"page":"e0341800","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Unraveling the mechanistic links between blood pressure regulation and calcium-magnesium homeostasis: Insights into hypertension, hyperparathyroidism, and mineral disorders"],"prefix":"10.1371","volume":"21","author":[{"given":"Pritha","family":"Dutta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1753-4063","authenticated-orcid":true,"given":"Anita T.","family":"Layton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2026,2,4]]},"reference":[{"issue":"9455","key":"pone.0341800.ref001","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0140-6736(05)17741-1","article-title":"Global burden of hypertension: analysis of worldwide data","volume":"365","author":"PM Kearney","year":"2005","journal-title":"Lancet."},{"issue":"6","key":"pone.0341800.ref002","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1161\/CIRCULATIONAHA.115.018912","article-title":"Global disparities of hypertension prevalence and control: a systematic analysis of population-based 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