{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T18:34:13Z","timestamp":1777055653895,"version":"3.51.4"},"reference-count":23,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aims to determine the effects of sleep quality along with age, marital status, socioeconomic status, depression, anxiety, disease activity, pain scale, and dose of corticosteroids on quality of life in women with SLE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Variables were assessed in 75 women with SLE using the Pittsburgh Sleep Quality Index (PSQI), Lupus Quality of Life (Lupus QoL), Depression, Anxiety, and Stress Scale-21 (DASS-21), and Mexican SLE Disease Activity Index (MEX-SLEDAI). Bivariate and multivariate analyses were performed to determine contributors to quality of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 75 subjects, 35 (46.7%) patients had poor sleep quality. The mean QoL score for patients is 84.27. Poor sleepers had impaired QoL in physical health (p\u2009=\u20090.003), emotional health (p\u2009=\u20090.007), pain (p\u2009=\u20090.003), and planning (p\u2009=\u20090.006), with fatigue (p\u2009&lt;\u20090.0001) as the most significantly impaired. Younger age (Mean\u2009\u00b1\u2009SD\u2009=\u200981.1\u2009\u00b1\u200912.67; p\u2009=\u20090.014) and anxiety or depression (Mean\u2009\u00b1\u2009SD\u2009=\u200956.66\u2009\u00b1\u20098.17; p\u2009=\u20090.006) were significantly associated with lower quality-of-life scores. The linear regression results showed an R-squared of 0.361, with anxiety (\u03b2\u2009=\u200921.402), sleep quality (\u03b2\u2009=\u20098.392), and age (\u03b2\u2009=\u20095.526) as the most significant variables. Marital status, socioeconomic status, disease activity, pain scale, and corticosteroid dose did not correlate with QoL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Poor sleep quality, anxiety, and younger age were significant independent predictors of lower QoL in women with SLE, explaining 36.1% of the variance. These findings suggest that psychosocial and sleep interventions are crucial for improving well-being in this population, potentially more so than focusing solely on disease activity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0341989","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T17:35:11Z","timestamp":1777052111000},"page":"e0341989","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Associated factors of health-related quality of life in Indonesian Women with Systemic Lupus Erythematosus: A cross-sectional within-cohort analysis"],"prefix":"10.1371","volume":"21","author":[{"given":"Euphemia Seto Anggraini","family":"Widyastuti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josephine","family":"Lavina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel Justin","family":"Darmajaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5866-6484","authenticated-orcid":true,"given":"Stevent","family":"Sumantri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2026,4,24]]},"reference":[{"issue":"2","key":"pone.0341989.ref001","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1002\/acr.20683","article-title":"Systematic review of the epidemiology of systemic lupus erythematosus in the Asia-Pacific region: prevalence, incidence, clinical features, and mortality","volume":"64","author":"RW Jakes","year":"2012","journal-title":"Arthritis Care Res (Hoboken)"},{"issue":"1","key":"pone.0341989.ref002","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/s11325-021-02405-0","article-title":"Association between depression and sleep quality in patients with systemic lupus erythematosus: a systematic review and meta-analysis","volume":"26","author":"R Yin","year":"2022","journal-title":"Sleep Breath"},{"issue":"2","key":"pone.0341989.ref003","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1000841","article-title":"Genome-wide association study in Asian populations identifies variants in ETS1 and WDFY4 associated with systemic lupus erythematosus","volume":"6","author":"W Yang","year":"2010","journal-title":"PLoS Genet"},{"issue":"9","key":"pone.0341989.ref004","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/s41584-021-00668-1","article-title":"Global epidemiology of systemic lupus erythematosus","volume":"17","author":"MRW Barber","year":"2021","journal-title":"Nat Rev Rheumatol"},{"issue":"7624","key":"pone.0341989.ref005","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1136\/bmj.39335.541782.AD","article-title":"Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies","volume":"335","author":"E von Elm","year":"2007","journal-title":"BMJ"},{"issue":"2","key":"pone.0341989.ref006","doi-asserted-by":"crossref","DOI":"10.37275\/ijr.v8i2.60","article-title":"Validity And Reliability Of Lupus Quality Of Life Questionnaire In Patients With Systemic Lupus Erythematosus In Indonesia","volume":"8","author":"B Anindito","year":"2018","journal-title":"Ina J Rheum"},{"issue":"3","key":"pone.0341989.ref007","doi-asserted-by":"crossref","first-page":"183","DOI":"10.15850\/amj.v11n3.3255","article-title":"Correlation of Platelet to Lymphocyte Ratio and C-Reactive Protein to Albumin Ratio with MEX-SLEDAI Scores in Patients with 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Tangkittiwet","year":"2025","journal-title":"Lupus"},{"issue":"9","key":"pone.0341989.ref017","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1002\/acr.21686","article-title":"Self-efficacy and pain catastrophizing in systemic lupus erythematosus: relationship to pain, stiffness, fatigue, and psychological distress","volume":"64","author":"TJ Somers","year":"2012","journal-title":"Arthritis Care Res (Hoboken)"},{"issue":"4","key":"pone.0341989.ref018","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.smrv.2009.10.007","article-title":"Sleep and emotions: a focus on insomnia","volume":"14","author":"C Baglioni","year":"2010","journal-title":"Sleep Med Rev"},{"issue":"11","key":"pone.0341989.ref019","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1002\/acr.24639","article-title":"Patient Experiences of Systemic Lupus Erythematosus: Findings From a Systematic Review, Meta-Summary, and Meta-Synthesis","volume":"74","author":"V 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Ed"},{"issue":"7","key":"pone.0341989.ref021","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/nrrheum.2009.106","article-title":"The socioeconomic burden of SLE","volume":"5","author":"CS Lau","year":"2009","journal-title":"Nat Rev Rheumatol"},{"issue":"2","key":"pone.0341989.ref022","doi-asserted-by":"crossref","first-page":"149","DOI":"10.20885\/intervensipsikologi.vol13.iss2.art6","article-title":"Intervensi Brief Behavioral Treatment of Insomnia Secara Daring Untuk Menurunkan Tingkat Gangguan Insomnia Klinis","volume":"13","author":"I Sukma Ardiatama","year":"2021","journal-title":"jip"},{"issue":"9","key":"pone.0341989.ref023","doi-asserted-by":"crossref","first-page":"22","DOI":"10.47941\/ijhs.2451","article-title":"Effectiveness of Mindfulness-Based Stress Reduction (MBSR) in Managing Hypertension among Adults in Indonesia","volume":"7","author":"D Anggraini","year":"2025","journal-title":"IJHS"}],"container-title":["PLOS One"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0341989","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T17:35:16Z","timestamp":1777052116000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0341989"}},"subtitle":[],"editor":[{"given":"Wesam","family":"Gouda","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2026,4,24]]},"references-count":23,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,4,24]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0341989","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,24]]}}}