{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T11:15:56Z","timestamp":1789730156926,"version":"4.0.1"},"reference-count":41,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T00:00:00Z","timestamp":1771804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Corstim SAS, Montpellier, France","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:p>The present study evaluated the effectiveness of transcranial alternating current stimulation (tACS) treating patients with post-stroke anomia using a picture-naming task and a Single-Case Experimental Design (SCED). A right-handed 38-year-old woman with a left-hemisphere stroke and a left-handed 54-year-old man with a right-hemisphere stroke underwent an eight-week treatment program. Specifically, they participated in a picture-naming task three times a week, alternating between sessions with and without tACS stimulation every two weeks. Electroencephalography (EEG) measurements were taken at the end of each two-week period, and behavioral data were collected before, during and after the treatment. EEG and behavioral assessments were also conducted at one- and three-month follow-ups. Picture-naming performance was significantly faster during tACS sessions compared to sessions without tACS. By the end of the intervention, both participants demonstrated improved accuracy and speed, with positive effects also observed in behavioral measures. EEG analysis showed that post-treatment brain activity resembled that of healthy individuals performing similar tasks. Patients\u2019 improvements in picture-naming and behavioral tests showed that the positive effects remained stable even after three months. Thus, preliminary data suggest that tACS might be a promising intervention for anomia, with lasting effects. Large-scale studies are needed to confirm these findings.<\/jats:p>","DOI":"10.1371\/journal.pone.0342191","type":"journal-article","created":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T18:30:33Z","timestamp":1771871433000},"page":"e0342191","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Transcranial Alternating Current Stimulation (tACS) for patients with Post-Stroke Anomia: Preliminary Data on Picture Naming Performance"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6536-7506","authenticated-orcid":true,"given":"Maria","family":"Martzoukou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5770-4303","authenticated-orcid":true,"given":"Nefeli K.","family":"Dimitriou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0822-5250","authenticated-orcid":true,"given":"Binbin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9726-3098","authenticated-orcid":true,"given":"Malo","family":"Renaud-D\u2019Ambra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia","family":"Nousia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Beuter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7495-6863","authenticated-orcid":true,"given":"Grigorios","family":"Nasios","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,2,23]]},"reference":[{"issue":"2","key":"pone.0342191.ref001","doi-asserted-by":"crossref","first-page":"183","DOI":"10.5853\/jos.2020.05015","article-title":"Current approaches to the treatment of post-stroke aphasia","volume":"23","author":"J Fridriksson","year":"2021","journal-title":"J Stroke"},{"key":"pone.0342191.ref002","unstructured":"Global Burden of Disease Collaborative Network. 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instrumentality and verb-noun name relation","volume":"97","author":"M Kambanaros","year":"2006","journal-title":"Brain Lang"},{"issue":"2","key":"pone.0342191.ref027","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1080\/1357650X.2013.783045","article-title":"Edinburgh Handedness Inventory - Short Form: A revised version based on confirmatory factor analysis","volume":"19","author":"JF Veale","year":"2014","journal-title":"Laterality"},{"issue":"1","key":"pone.0342191.ref028","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/s41597-022-01552-7","article-title":"The multilingual picture database","volume":"9","author":"JA Du\u00f1abeitia","year":"2022","journal-title":"Sci Data"},{"issue":"5","key":"pone.0342191.ref029","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1080\/09602011.2013.824383","article-title":"Revision of a method quality rating scale for single-case experimental designs and n-of-1 trials: The 15-item Risk of Bias in N-of-1 Trials 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Kasselimis","year":"2020","journal-title":"Front Psychol"},{"issue":"4","key":"pone.0342191.ref033","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1163\/156856897X00357","article-title":"The Psychophysics Toolbox","volume":"10","author":"DH Brainard","year":"1997","journal-title":"Spat Vis"},{"issue":"1","key":"pone.0342191.ref034","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jneumeth.2003.10.009","article-title":"EEGLAB: An open source toolbox for analysis of single-trial EEG dynamics including independent component analysis","volume":"134","author":"A Delorme","year":"2004","journal-title":"J Neurosci Methods"},{"key":"pone.0342191.ref035","unstructured":"Saturnino G, Antunes A, Stelzer J, Thielscher A. SimNIBS: a versatile toolbox for simulating fields generated by transcranial brain stimulation. 21st Annual Meeting of the Organization for Human Brain Mapping; 2015."},{"issue":"4","key":"pone.0342191.ref036","doi-asserted-by":"crossref","first-page":"343","DOI":"10.3390\/brainsci15040343","article-title":"Repetitive Gamma-tACS improves the reaction times of healthy young adults in a visuospatial working memory task: A randomized study","volume":"15","author":"M Rosato","year":"2025","journal-title":"Brain Sci"},{"key":"pone.0342191.ref037","doi-asserted-by":"crossref","first-page":"632545","DOI":"10.3389\/fragi.2021.632545","article-title":"A novel program to improve cognitive function in individuals with dementia using transcranial alternating current stimulation (tACS) and tutored cognitive exercises","volume":"2","author":"Z Moussavi","year":"2021","journal-title":"Front Aging"},{"key":"pone.0342191.ref038","doi-asserted-by":"crossref","first-page":"114322","DOI":"10.1016\/j.bbr.2023.114322","article-title":"Aging effects on electrical and hemodynamic responses in the sensorimotor network during unilateral proximal upper limb functional tasks","volume":"443","author":"CO Muller","year":"2023","journal-title":"Behav Brain Res"},{"key":"pone.0342191.ref039","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/1743-0003-11-90","article-title":"Modulation of event-related desynchronization during kinematic and kinetic hand movements","volume":"11","author":"K Nakayashiki","year":"2014","journal-title":"J Neuroeng Rehabil"},{"issue":"6","key":"pone.0342191.ref040","doi-asserted-by":"crossref","first-page":"11429","DOI":"10.3934\/mbe.2023507","article-title":"Characterization of spatiotemporal dynamics in EEG data during picture naming with optical flow patterns","volume":"20","author":"V Volpert","year":"2023","journal-title":"Math Biosci Eng"},{"key":"pone.0342191.ref041","author":"V Volpert","year":"2023"}],"container-title":["PLOS One"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0342191","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T18:30:42Z","timestamp":1771871442000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0342191"}},"subtitle":[],"editor":[{"given":"Thiago P.","family":"Fernandes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,2,23]]},"references-count":41,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,2,23]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0342191","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,23]]}}}