{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T16:36:01Z","timestamp":1774802161886,"version":"3.50.1"},"reference-count":29,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the National Natural Science Foundation of China, Youth Science Foundation Project","award":["No. 72204073"],"award-info":[{"award-number":["No. 72204073"]}]},{"name":"Zhejiang Medical and Health Science and Technology","award":["No. 2023KY491"],"award-info":[{"award-number":["No. 2023KY491"]}]},{"name":"Zhejiang Yangtze River Delta Health Science Research Fund Project","award":["No. 2022CSJ-A002"],"award-info":[{"award-number":["No. 2022CSJ-A002"]}]},{"name":"Second batch of undergraduate provincial-level teaching reform record projects in the 14th Five-Year Plan","award":["No. JGBA2024643"],"award-info":[{"award-number":["No. JGBA2024643"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The triglyceride-cholesterol-body weight index (TCBI) is a simple and reliable indicator of nutritional status. This investigation aimed to explore the association between TCBI and sarcopenia among older individuals in China.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The AWGS 2019 criteria were utilized to evaluate sarcopenia. TCBI was calculated as (TG\u2009\u00d7\u2009TC\u2009\u00d7\u2009BW)\/1000. Logistic regression analysis explored the independent connection between TCBI and the occurrence of sarcopenia. RCS was employed to investigate both linear and nonlinear correlations, and threshold effects were scrutinized. Furthermore, subgroup and sensitivity analyses were also conducted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>This study included 5293 participants. The TCBI was found to be negatively associated with sarcopenia in a fully corrected model, with a 66% decrease in the prevalence of sarcopenia for each 1-unit increase in LgTCBI (OR = 0.34; 95% CI: 0.28\u20130.41; p\u2009&lt;\u20090.001). The study showed that this association was further highlighted in those with normal BMI and remains consistent in sensitivity analyses. Furthermore, we found a nonlinear association between both TCBI and sarcopenia, with an inflection point of 7.05 by the RCS curve and threshold effect analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study revealed a nonlinear negative correlation between TCBI and sarcopenia, highlighting the implications of these findings for the early screening and timely intervention of sarcopenia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0342265","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T18:33:24Z","timestamp":1770230004000},"page":"e0342265","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association between triglyceride-cholesterol-body weight index and sarcopenia in the older adults from China: A cross-sectional study"],"prefix":"10.1371","volume":"21","author":[{"given":"Yanmei","family":"Ning","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doudou","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiana","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6067-5029","authenticated-orcid":true,"given":"Ying","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2026,2,4]]},"reference":[{"issue":"1","key":"pone.0342265.ref001","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/s41572-024-00550-w","article-title":"Sarcopenia","volume":"10","author":"AA Sayer","year":"2024","journal-title":"Nat Rev Dis Primers"},{"issue":"1","key":"pone.0342265.ref002","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1002\/jcsm.12783","article-title":"Global prevalence of sarcopenia and severe sarcopenia: a systematic review and meta-analysis","volume":"13","author":"F Petermann-Rocha","year":"2022","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"3","key":"pone.0342265.ref003","article-title":"Asian Working Group for Sarcopenia: 2019 Consensus Update on Sarcopenia Diagnosis and Treatment","volume":"21","author":"L-K Chen","year":"2020","journal-title":"J Am Med Dir Assoc"},{"issue":"3","key":"pone.0342265.ref004","article-title":"Sarcopenia prevalence and associated factors among older Chinese population: Findings from the China Health and Retirement Longitudinal Study","volume":"16","author":"X Wu","year":"2021","journal-title":"PLoS One"},{"key":"pone.0342265.ref005","doi-asserted-by":"crossref","first-page":"155533","DOI":"10.1016\/j.metabol.2023.155533","article-title":"Epidemiology of sarcopenia: Prevalence, risk factors, and consequences","volume":"144","author":"S Yuan","year":"2023","journal-title":"Metabolism"},{"issue":"6","key":"pone.0342265.ref006","doi-asserted-by":"crossref","first-page":"2944","DOI":"10.1002\/jcsm.13081","article-title":"Sarcopenia and mild cognitive impairment among elderly adults: The first longitudinal evidence from CHARLS","volume":"13","author":"Y Hu","year":"2022","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"11","key":"pone.0342265.ref007","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.3390\/nu16111717","article-title":"Prognostic Value of New Sarcopenia Screening Tool in the Elderly-SARC-GLOBAL","volume":"16","author":"ACC Vicedomini","year":"2024","journal-title":"Nutrients"},{"issue":"14","key":"pone.0342265.ref008","doi-asserted-by":"crossref","first-page":"8718","DOI":"10.3390\/ijerph19148718","article-title":"Protein Intake and Sarcopenia in Older Adults: A Systematic Review and Meta-Analysis","volume":"19","author":"HJ Coelho-Junior","year":"2022","journal-title":"Int J Environ Res Public Health"},{"issue":"5","key":"pone.0342265.ref009","doi-asserted-by":"crossref","first-page":"100428","DOI":"10.1016\/j.advnut.2025.100428","article-title":"Prognostic and Associative Significance of Malnutrition in Sarcopenia: A Systematic Review and Meta-Analysis","volume":"16","author":"K Prokopidis","year":"2025","journal-title":"Adv Nutr"},{"issue":"1","key":"pone.0342265.ref010","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/0002-9610(80)90246-9","article-title":"Prognostic nutritional index in gastrointestinal surgery","volume":"139","author":"GP Buzby","year":"1980","journal-title":"Am J Surg"},{"issue":"1","key":"pone.0342265.ref011","first-page":"38","article-title":"CONUT: a tool for controlling nutritional status. 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